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Maki, Carl
One or more keywords matched the following items that are connected to
Maki, Carl
Item Type
Name
Concept
Proto-Oncogene Proteins c-myc
Concept
Proto-Oncogene Proteins c-bcl-2
Concept
Proto-Oncogene Proteins c-mdm2
Concept
Proto-Oncogene Proteins
Concept
Proto-Oncogene Proteins c-akt
Academic Article
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT.
Academic Article
Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.
Academic Article
p53-regulated autophagy is controlled by glycolysis and determines cell fate.
Academic Article
Modeling the Etiology of p53-mutated Cancer Cells.
Academic Article
Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.
Academic Article
Physical and functional interactions between PML and MDM2.
Academic Article
Stability and ubiquitination of the tumor suppressor protein p53.
Academic Article
MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53.
Academic Article
Control of p53 nuclear accumulation in stressed cells.
Academic Article
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity.
Academic Article
MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation.
Academic Article
Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination.
Academic Article
p53 and p21(Waf1) are recruited to distinct PML-containing nuclear foci in irradiated and Nutlin-3a-treated U2OS cells.
Academic Article
Pharmacologic activation of p53 by small-molecule MDM2 antagonists.
Academic Article
Glucocorticoid receptor activation inhibits p53-induced apoptosis of MCF10Amyc cells via induction of protein kinase Ce.
Academic Article
Novel roles for p53 in the genesis and targeting of tetraploid cancer cells.
Academic Article
The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis.
Academic Article
Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3.
Academic Article
MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding.
Academic Article
Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents.
Academic Article
MDM2-dependent ubiquitination of nuclear and cytoplasmic P53.
Academic Article
The MDM2 RING-finger domain is required to promote p53 nuclear export.
Academic Article
Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation.
Academic Article
Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2.
Academic Article
p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a.
Academic Article
DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a.
Academic Article
The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells.
Academic Article
Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice.
Academic Article
Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer.
Academic Article
Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells.
Academic Article
Mixed lineage kinase 3 and CD70 cooperation sensitize trastuzumab-resistant HER2+ breast cancer by ceramide-loaded nanoparticles.
Search Criteria
Proto Oncogenes