"Trefoil Factor-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 106 amino acid (12 kDa) trefoil factor that contains two trefoil domains and associates with MUCIN-6. It is expressed in the GASTROINTESTINAL TRACT by cells of BRUNNER GLANDS; PYLORIC GLANDS and mucous neck cells. It inhibits GASTROINTESTINAL MOTILITY and GASTRIC ACID secretion and may help maintain the structural integrity of gastric mucus.
| Descriptor ID |
D000071164
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| MeSH Number(s) |
D12.644.937.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Trefoil Factor-2".
Below are MeSH descriptors whose meaning is more specific than "Trefoil Factor-2".
This graph shows the total number of publications written about "Trefoil Factor-2" by people in this website by year, and whether "Trefoil Factor-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "Trefoil Factor-2" by people in Profiles.
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Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol. 2005 Aug; 116(2):305-11.
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A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells. J Clin Invest. 1999 Dec; 104(11):1539-47.
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Goblet-cell-specific transcription of mouse intestinal trefoil factor gene results from collaboration of complex series of positive and negative regulatory elements. Biochem J. 1999 Jul 15; 341 ( Pt 2):461-72.
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Identification of a goblet cell-specific enhancer element in the rat intestinal trefoil factor gene promoter bound by a goblet cell nuclear protein. J Biol Chem. 1998 Jan 30; 273(5):3060-7.