"Transglutaminases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
| Descriptor ID |
D011503
|
| MeSH Number(s) |
D08.811.913.050.200.800
|
| Concept/Terms |
Transglutaminases- Transglutaminases
- Protein-Glutamine gamma-Glutamyltransferases
- Protein Glutamine gamma Glutamyltransferases
- gamma-Glutamyltransferases, Protein-Glutamine
- Glutaminyl-Peptide Gamma-Glutamyltransferases
- Gamma-Glutamyltransferases, Glutaminyl-Peptide
- Glutaminyl Peptide Gamma Glutamyltransferases
|
Below are MeSH descriptors whose meaning is more general than "Transglutaminases".
Below are MeSH descriptors whose meaning is more specific than "Transglutaminases".
This graph shows the total number of publications written about "Transglutaminases" by people in this website by year, and whether "Transglutaminases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transglutaminases" by people in Profiles.
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Tissue Transglutaminase and Its Product Isopeptide Are Increased in Alzheimer's Disease and APPswe/PS1dE9 Double Transgenic Mice Brains. Mol Neurobiol. 2016 10; 53(8):5066-78.
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Cognitive performance correlates with cortical isopeptide immunoreactivity as well as Alzheimer type pathology. J Alzheimers Dis. 2008 Feb; 13(1):53-66.
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Topical delivery of 13-cis-retinoic acid by inhalation up-regulates expression of rodent lung but not liver retinoic acid receptors. Clin Cancer Res. 2000 Sep; 6(9):3636-45.