"alpha-Macroglobulins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
| Descriptor ID |
D000511
|
| MeSH Number(s) |
D12.776.124.050.080 D12.776.124.790.106.100 D12.776.124.790.720.100 D12.776.377.715.085.100 D12.776.377.715.647.100
|
| Concept/Terms |
alpha-Macroglobulins- alpha-Macroglobulins
- alpha Macroglobulins
- 45S RNP
- RNP, 45S
- alpha-Macrofetoproteins
- alpha Macrofetoproteins
Slow alpha 2-Macroglobulins- Slow alpha 2-Macroglobulins
- Slow alpha 2 Macroglobulins
- alpha 2-Macroglobulins, Slow
- Slow alpha 2-Globulin
- Slow alpha 2 Globulin
- alpha 2-Globulin, Slow
alpha 1-Acute Phase Protein- alpha 1-Acute Phase Protein
- alpha 1 Acute Phase Protein
- Acute-Phase alpha 1-Protein
- Acute Phase alpha 1 Protein
- alpha 1-Protein, Acute-Phase
|
Below are MeSH descriptors whose meaning is more general than "alpha-Macroglobulins".
Below are MeSH descriptors whose meaning is more specific than "alpha-Macroglobulins".
This graph shows the total number of publications written about "alpha-Macroglobulins" by people in this website by year, and whether "alpha-Macroglobulins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "alpha-Macroglobulins" by people in Profiles.
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Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017 12 01; 74(12):1473-1480.
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Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through Toll-like receptor 4. Arthritis Rheumatol. 2015 Nov; 67(11):2933-43.
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Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. J Biol Chem. 2004 Apr 23; 279(17):17554-61.
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Degradation of a chromogenic substrate by alpha 2-macroglobulin from plasma of patients with rheumatoid arthritis. Arthritis Rheum. 1984 Oct; 27(10):1122-9.