Interleukin 1 Receptor Antagonist Protein
"Interleukin 1 Receptor Antagonist Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.
| Descriptor ID |
D053590
|
| MeSH Number(s) |
D12.644.276.374.460 D12.776.467.374.460 D23.529.374.460
|
| Concept/Terms |
Interleukin 1 Receptor Antagonist Protein- Interleukin 1 Receptor Antagonist Protein
- IL1 Febrile Inhibitor
- Febrile Inhibitor, IL1
- IL-1Ra
- Urine-Derived IL1 Inhibitor
- IL1 Inhibitor, Urine-Derived
- Urine Derived IL1 Inhibitor
- IL-1 Inhibitor, Urine
- IL 1 Inhibitor, Urine
- Urine IL-1 Inhibitor
- Interleukin 1 Inhibitor, Urine
|
Below are MeSH descriptors whose meaning is more general than "Interleukin 1 Receptor Antagonist Protein".
Below are MeSH descriptors whose meaning is more specific than "Interleukin 1 Receptor Antagonist Protein".
This graph shows the total number of publications written about "Interleukin 1 Receptor Antagonist Protein" by people in this website by year, and whether "Interleukin 1 Receptor Antagonist Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interleukin 1 Receptor Antagonist Protein" by people in Profiles.
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Cytokine Inhibitors Upregulate Extracellular Matrix Anabolism of Human Intervertebral Discs under Alginate Beads and Alginate-Embedded Explant Cultures. Int J Mol Sci. 2023 Aug 02; 24(15).
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Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis. J Neurochem. 2017 05; 141(3):423-435.
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An anti-inflammatory property of Candida albicans ?-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism. Cytokine. 2015 Feb; 71(2):215-22.
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Development and validation of a plasma biomarker panel for discerning clinical significance of indeterminate pulmonary nodules. J Thorac Oncol. 2013 Jan; 8(1):31-6.
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Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense. J Immunol. 2012 Jul 15; 189(2):1002-13.
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Does manipulating local surgical wound cytokines improve surgical outcomes? Anesth Analg. 2010 Dec; 111(6):1335-6.
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Cytokine gene expression after total hip arthroplasty: surgical site versus circulating neutrophil response. Anesth Analg. 2009 Sep; 109(3):959-64.
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Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med. 1997 Jul; 25(7):1115-24.
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Indication of an involvement of interleukin-1 beta converting enzyme-like protease in intramedullary apoptotic cell death in the bone marrow of patients with myelodysplastic syndromes. Blood. 1996 Oct 01; 88(7):2640-7.
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Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA. 1994 Jun 15; 271(23):1836-43.