"Apolipoprotein E4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
| Descriptor ID |
D053327
|
| MeSH Number(s) |
D10.532.091.500.750 D12.776.070.400.500.750 D12.776.521.120.500.750
|
| Concept/Terms |
Apolipoprotein E4- Apolipoprotein E4
- Apolipoprotein E-4
- Apolipoprotein E 4
- Apo E4
- ApoE4
- Apo E epsilon 4
- Apo E-4
- Apo E 4
|
Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E4".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E4".
This graph shows the total number of publications written about "Apolipoprotein E4" by people in this website by year, and whether "Apolipoprotein E4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2005 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 1 | 2 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 3 | 0 | 3 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Apolipoprotein E4" by people in Profiles.
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APOE4, Blood Neurodegenerative Biomarkers, and Cognitive Decline in Community-Dwelling Older Adults. JAMA Netw Open. 2025 May 01; 8(5):e258903.
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Longitudinal associations between lipid panel and cognitive decline modified by APOE 4 carrier status in biracial community-dwelling older adults: Findings from the Chicago health and aging project. Arch Gerontol Geriatr. 2025 Jul; 134:105825.
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Dietary fats and the APOE-e4 risk allele in relation to cognitive decline: a longitudinal investigation in a biracial population sample. J Nutr Health Aging. 2024 May; 28(5):100211.
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Cognitive Aging in Black and White Americans: Cognition, Cognitive Decline, and Incidence of Alzheimer Disease Dementia. Epidemiology. 2018 01; 29(1):151-159.
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APOE e4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. PLoS One. 2017; 12(7):e0180356.
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Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology. J Alzheimers Dis. 2017; 56(2):699-706.
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Role of APOE e4 Allele and Incident Stroke on Cognitive Decline and Mortality. Alzheimer Dis Assoc Disord. 2016 Oct-Dec; 30(4):318-323.
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Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-e4. Alzheimer Dis Assoc Disord. 2016 Jul-Sep; 30(3):210-5.
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APOE e4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology. 2016 05 31; 86(22):2063-70.
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APOE and cerebral amyloid angiopathy in community-dwelling older persons. Neurobiol Aging. 2015 Nov; 36(11):2946-2953.