"Apolipoprotein E4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
| Descriptor ID |
D053327
|
| MeSH Number(s) |
D10.532.091.500.750 D12.776.070.400.500.750 D12.776.521.120.500.750
|
| Concept/Terms |
Apolipoprotein E4- Apolipoprotein E4
- Apolipoprotein E-4
- Apolipoprotein E 4
- Apo E4
- ApoE4
- Apo E epsilon 4
- Apo E-4
- Apo E 4
|
Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E4".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E4".
This graph shows the total number of publications written about "Apolipoprotein E4" by people in this website by year, and whether "Apolipoprotein E4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2005 | 0 | 4 | 4 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 1 | 2 |
| 2009 | 2 | 4 | 6 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 2 | 4 |
| 2013 | 5 | 1 | 6 |
| 2014 | 3 | 3 | 6 |
| 2015 | 2 | 2 | 4 |
| 2016 | 4 | 1 | 5 |
| 2017 | 1 | 2 | 3 |
| 2018 | 4 | 3 | 7 |
| 2019 | 3 | 3 | 6 |
| 2020 | 5 | 2 | 7 |
| 2021 | 4 | 4 | 8 |
| 2022 | 5 | 6 | 11 |
| 2023 | 2 | 1 | 3 |
| 2024 | 1 | 0 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Apolipoprotein E4" by people in Profiles.
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APOE4, Blood Neurodegenerative Biomarkers, and Cognitive Decline in Community-Dwelling Older Adults. JAMA Netw Open. 2025 May 01; 8(5):e258903.
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Longitudinal associations between lipid panel and cognitive decline modified by APOE 4 carrier status in biracial community-dwelling older adults: Findings from the Chicago health and aging project. Arch Gerontol Geriatr. 2025 Jul; 134:105825.
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Dietary fats and the APOE-e4 risk allele in relation to cognitive decline: a longitudinal investigation in a biracial population sample. J Nutr Health Aging. 2024 May; 28(5):100211.
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Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults. JAMA Neurol. 2023 09 01; 80(9):929-939.
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Race and Apolipoprotein E-e4 Allele Status Differences in the Association Between Loneliness and Cognitive Decline. Psychosom Med. 2023 04 01; 85(3):231-237.
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Association of Vitamin E and Cognitive Decline in Older Adults with and without the APOE?4 Allele: A Biracial Population-Based Community Study. J Alzheimers Dis. 2023; 96(3):1129-1138.
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Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer's dementia. Alzheimers Res Ther. 2022 10 11; 14(1):152.
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Brain copper may protect from cognitive decline and Alzheimer's disease pathology: a community-based study. Mol Psychiatry. 2022 10; 27(10):4307-4313.
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APOE e4 and Alzheimer's disease diagnosis associated differences in L-carnitine, GBB, TMAO, and acylcarnitines in blood and brain. Curr Res Transl Med. 2023 Jan-Mar; 71(1):103362.
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Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults. Neurology. 2022 08 23; 99(8):e789-e798.