"CD18 Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.
| Descriptor ID |
D018821
|
| MeSH Number(s) |
D12.776.395.550.200.275.750 D12.776.543.550.200.275.750 D12.776.543.750.705.408.200.249 D12.776.543.750.705.408.600.100.750 D12.776.543.750.705.833.249.750 D23.050.301.264.894.118 D23.050.301.350.275.750 D23.101.100.894.118
|
| Concept/Terms |
CD18 Antigens- CD18 Antigens
- p150,95 beta-Subunit
- beta-Subunit, p150,95
- p150,95 beta Subunit
- Integrin beta2
- beta2, Integrin
- beta2 Integrin
- Integrin, beta2
- CD18 Antigen
- Antigens, CD18
|
Below are MeSH descriptors whose meaning is more general than "CD18 Antigens".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Cell Adhesion Molecules [D12.776.395.550.200]
- Integrin alphaXbeta2 [D12.776.395.550.200.275]
- CD18 Antigens [D12.776.395.550.200.275.750]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Cell Adhesion Molecules [D12.776.543.550.200]
- Integrin alphaXbeta2 [D12.776.543.550.200.275]
- CD18 Antigens [D12.776.543.550.200.275.750]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Integrins [D12.776.543.750.705.408]
- Integrin beta Chains [D12.776.543.750.705.408.200]
- CD18 Antigens [D12.776.543.750.705.408.200.249]
- Receptors, Leukocyte-Adhesion [D12.776.543.750.705.408.600]
- Integrin alphaXbeta2 [D12.776.543.750.705.408.600.100]
- CD18 Antigens [D12.776.543.750.705.408.600.100.750]
- Receptors, Complement [D12.776.543.750.705.833]
- Integrin alphaXbeta2 [D12.776.543.750.705.833.249]
- CD18 Antigens [D12.776.543.750.705.833.249.750]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
- CD18 Antigens [D23.050.301.264.894.118]
- Cell Adhesion Molecules [D23.050.301.350]
- Integrin alphaXbeta2 [D23.050.301.350.275]
- CD18 Antigens [D23.050.301.350.275.750]
- Biomarkers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
- CD18 Antigens [D23.101.100.894.118]
Below are MeSH descriptors whose meaning is more specific than "CD18 Antigens".
This graph shows the total number of publications written about "CD18 Antigens" by people in this website by year, and whether "CD18 Antigens" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "CD18 Antigens" by people in Profiles.
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A Genetic Model of Constitutively Active Integrin CD11b/CD18. J Immunol. 2020 11 01; 205(9):2545-2553.
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Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury. Biochim Biophys Acta. 2013 Jun; 1830(6):3696-710.
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Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci Signal. 2011 Sep 06; 4(189):ra57.
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Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function. J Immunol. 2008 Feb 01; 180(3):1713-8.
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A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen. 2007 Apr; 12(3):406-17.
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The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood. 2007 Apr 15; 109(8):3513-20.
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E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeability. Am J Physiol Lung Cell Mol Physiol. 2003 Oct; 285(4):L879-88.
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Lymphocyte adhesion to Candida albicans. Infect Immun. 2002 Feb; 70(2):517-27.
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Fas activation reduces neutrophil adhesion to endothelial cells. J Leukoc Biol. 2000 Nov; 68(5):715-22.
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Immunolocalization of integrins in the normal lung and in pulmonary carcinomas. Hum Pathol. 1997 Sep; 28(9):1018-25.