"Dizocilpine Maleate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
| Descriptor ID |
D016291
|
| MeSH Number(s) |
D02.455.426.559.847.181.384.380 D04.615.181.384.380
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Dizocilpine Maleate".
Below are MeSH descriptors whose meaning is more specific than "Dizocilpine Maleate".
This graph shows the total number of publications written about "Dizocilpine Maleate" by people in this website by year, and whether "Dizocilpine Maleate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dizocilpine Maleate" by people in Profiles.
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The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain. Int J Dev Neurosci. 2011 Nov; 29(7):767-73.
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Antinociceptive potentiation and attenuation of tolerance by intrathecal co-infusion of magnesium sulfate and morphine in rats. Anesth Analg. 1998 Apr; 86(4):830-6.
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Differential regulation of calcium/calmodulin-dependent protein kinase II and p42 MAP kinase activity by synaptic transmission. J Neurosci. 1994 Mar; 14(3 Pt 1):1320-31.
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Spontaneous synchronous synaptic calcium transients in cultured cortical neurons. J Neurosci. 1992 Dec; 12(12):4834-45.