"Versicans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
HYALURONAN-containing proteoglycans found in the EXTRACELLULAR MATRIX of a variety of tissues and organs. Several versican isoforms exist due to multiple ALTERNATIVE SPLICING of the versican MESSENGER RNA.
| Descriptor ID |
D053675
|
| MeSH Number(s) |
D09.698.735.200.750 D12.776.395.650.750.687.800 D12.776.503.280.437.800 D12.776.860.300.885
|
| Concept/Terms |
Versicans- Versicans
- Versican
- Chondroitin Sulfate Proteoglycan Core Protein 2
|
Below are MeSH descriptors whose meaning is more general than "Versicans".
Below are MeSH descriptors whose meaning is more specific than "Versicans".
This graph shows the total number of publications written about "Versicans" by people in this website by year, and whether "Versicans" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Versicans" by people in Profiles.
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Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican. Cells. 2020 07 13; 9(7).
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Disentangling the genetics of lean mass. Am J Clin Nutr. 2019 02 01; 109(2):276-287.
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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017 07 19; 8(1):80.
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Deletion of ADAMTS5 does not affect aggrecan or versican degradation but promotes glucose uptake and proteoglycan synthesis in murine adipose derived stromal cells. Matrix Biol. 2015 Sep; 47:66-84.
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Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthop Res. 2011 Apr; 29(4):516-22.
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Age-related differences in human skin proteoglycans. Glycobiology. 2011 Feb; 21(2):257-68.
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Cell death-associated ADAMTS4 and versican degradation in vascular tissue. J Histochem Cytochem. 2009 Sep; 57(9):889-97.
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Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns. 2009 Jun; 9(5):314-23.
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Versican degradation and vascular disease. Trends Cardiovasc Med. 2006 Aug; 16(6):209-15.
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ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein. Biochem J. 2004 Feb 01; 377(Pt 3):787-95.