"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
| Descriptor ID |
D018345
|
| MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
|
| Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 5 | 5 |
| 2002 | 0 | 6 | 6 |
| 2003 | 0 | 8 | 8 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 5 | 5 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 14 | 14 |
| 2008 | 0 | 15 | 15 |
| 2009 | 0 | 15 | 15 |
| 2010 | 0 | 11 | 11 |
| 2011 | 0 | 14 | 14 |
| 2012 | 0 | 10 | 10 |
| 2013 | 0 | 11 | 11 |
| 2014 | 0 | 15 | 15 |
| 2015 | 0 | 16 | 16 |
| 2016 | 0 | 11 | 11 |
| 2017 | 0 | 9 | 9 |
| 2018 | 0 | 9 | 9 |
| 2019 | 0 | 15 | 15 |
| 2020 | 0 | 6 | 6 |
| 2021 | 0 | 9 | 9 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
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Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis. Nat Commun. 2023 04 29; 14(1):2479.
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Colon epithelial cell-specific Bmal1 deletion impairs bone formation in mice. Bone. 2023 03; 168:116650.
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Therapeutic evaluation of immunomodulators in reducing surgical wound infection. FASEB J. 2022 01; 36(1):e22090.
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?-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages. J Immunol. 2021 12 01; 207(11):2785-2798.
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Deiodinase-3 is a thyrostat to regulate podocyte homeostasis. EBioMedicine. 2021 Oct; 72:103617.
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Selective targeting of the TLR2/MyD88/NF-?B pathway reduces a-synuclein spreading in vitro and in vivo. Nat Commun. 2021 09 10; 12(1):5382.
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Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology. Acta Neuropathol Commun. 2021 08 19; 9(1):139.
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Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021 07 27; 9(1):129.
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Neonatal thyroxine activation modifies epigenetic programming of the liver. Nat Commun. 2021 07 21; 12(1):4446.
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Up-Regulation of the Long Noncoding RNA X-Inactive-Specific Transcript and the Sex Bias in Pulmonary Arterial Hypertension. Am J Pathol. 2021 06; 191(6):1135-1150.