 Quinidine
"Quinidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
| Descriptor ID |
D011802
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| MeSH Number(s) |
D03.132.206.636 D03.438.810.699 D03.605.687.637
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| Concept/Terms |
Apo-Quinidine- Apo-Quinidine
- Apo Quinidine
- Apotex Brand of Quinidine Sulfate
Quinidex- Quinidex
- Robins Brand of Quinidine Sulfate
Adaquin- Adaquin
- Nelson Brand of Quinidine Sulfate
Quincardine- Quincardine
- Fawns & McAllan Brand of Quinidine Sulfate
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Below are MeSH descriptors whose meaning is more general than "Quinidine".
Below are MeSH descriptors whose meaning is more specific than "Quinidine".
This graph shows the total number of publications written about "Quinidine" by people in this website by year, and whether "Quinidine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1983 | 1 | 0 | 1 | | 1984 | 1 | 3 | 4 | | 1985 | 0 | 1 | 1 | | 1986 | 1 | 1 | 2 | | 1990 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Quinidine" by people in Profiles.
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Cvetanovic I, Lin C, Ranade V, Keshavarzian A, Somberg J. The effects of quinidine and its chiral isolates on erg-1sm potassium current and correlation with gastrointestinal augmentation. Am J Ther. 2007 May-Jun; 14(3):269-76.
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Lin C, Cvetanovic I, Ke X, Ranade V, Somberg J. A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels. Am J Ther. 2005 Jul-Aug; 12(4):328-36.
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Lin C, Ke X, Cvetanovic I, Ranade V, Somberg J. The influence of extracellular acidosis on the effect of IKr blockers. J Cardiovasc Pharmacol Ther. 2005 Mar; 10(1):67-76.
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Jacobs ER, DeCoursey TE. Mechanisms of potassium channel block in rat alveolar epithelial cells. J Pharmacol Exp Ther. 1990 Nov; 255(2):459-72.
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Somberg JC, Miura D, Keefe DL. The treatment of ventricular rhythm disturbances. Am Heart J. 1986 Jun; 111(6):1162-76.
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Morganroth J, Somberg JC, Pool PE, Hsu PH, Lee IK, Durkee J, Salerno DM. Comparative study of encainide and quinidine in the treatment of ventricular arrhythmias. J Am Coll Cardiol. 1986 Jan; 7(1):9-16.
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Somberg J. Antiarrhythmic drug therapy. Recent advances and current status. Cardiology. 1985; 72(5-6):329-48.
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Torres V, Flowers D, Miura D, Somberg J. Intravenous quinidine by intermittent bolus for electrophysiologic studies in patients with ventricular tachycardia. Am Heart J. 1984 Dec; 108(6):1437-42.
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Keren G, Tepper D, Butler B, Torres V, Somberg JC. The effect of bepridil, verapamil, and quinidine in the prevention of ventricular tachycardia induced by programmed electrical stimulation in the digitalized dog. Am Heart J. 1984 Nov; 108(5):1236-43.
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Keren G, Tepper D, Butler B, Miura D, Aogaichi K, Somberg J. The efficacy of cibenzoline in preventing PES induction of ventricular tachycardia in the dog. J Clin Pharmacol. 1984 Oct; 24(10):466-72.
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