Last Name

Jun Lu

InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
Address1750 W.Harrison St
Chicago IL 60612
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    My Faculty Profile at Rush University Medical Center:

    My Laboratory:

    PhD, Northwestern Polytechnical Univeristy, Xian, China
    MS, Northwest Univeristy, Xian, China
    BS, Yanan University, Yanan, China

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lu J, Baccei A, Lummertz da Rocha E, Guillermier C, McManus S, Finney LA, Zhang C, Steinhauser ML, Li H, Lerou PH. Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm. Stem Cell Res. 2018 04; 28:48-55. PMID: 29427839.
      View in: PubMed
    2. Chen MC, Vetrivelan R, Guo CN, Chang C, Fuller PM, Lu J. Ventral medullary control of rapid eye movement sleep and atonia. Exp Neurol. 2017 04; 290:53-62. PMID: 28077261.
      View in: PubMed
    3. Vetrivelan R, Kong D, Ferrari LL, Arrigoni E, Madara JC, Bandaru SS, Lowell BB, Lu J, Saper CB. Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice. Neuroscience. 2016 Nov 12; 336:102-113. PMID: 27595887.
      View in: PubMed
    4. Qiu MH, Chen MC, Fuller PM, Lu J. Stimulation of the Pontine Parabrachial Nucleus Promotes Wakefulness via Extra-thalamic Forebrain Circuit Nodes. Curr Biol. 2016 09 12; 26(17):2301-12. PMID: 27546576.
      View in: PubMed
    5. Lu J, Chen M. Glial Gap Junctions Boost Modafinil Action on Arousal. Sleep. 2016 06 01; 39(6):1175-7. PMID: 27166230; PMCID: PMC4863203 [Available on 12/01/16].
    6. Lu J, Li H, Baccei A, Sasaki T, Gilbert DM, Lerou PH. Influence of ATM-Mediated DNA Damage Response on Genomic Variation in Human Induced Pluripotent Stem Cells. Stem Cells Dev. 2016 05 01; 25(9):740-7. PMID: 26935587; PMCID: PMC4854209 [Available on 05/01/17].
    7. Chen MC, Chiang WY, Yugay T, Patxot M, Özçivit IB, Hu K, Lu J. Anterior Insula Regulates Multiscale Temporal Organization of Sleep and Wake Activity. J Biol Rhythms. 2016 Apr; 31(2):182-93. PMID: 26825619; PMCID: PMC4803073 [Available on 04/01/17].
    8. Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Commun. 2015 Oct 23; 6:8715. PMID: 26493500; PMCID: PMC4620584.
    9. Sherman D, Fuller PM, Marcus J, Yu J, Zhang P, Chamberlin NL, Saper CB, Lu J. Anatomical Location of the Mesencephalic Locomotor Region and Its Possible Role in Locomotion, Posture, Cataplexy, and Parkinsonism. Front Neurol. 2015; 6:140. PMID: 26157418; PMCID: PMC4478394.
    10. Chang CH, Chen MC, Lu J. Effect of antidepressant drugs on the vmPFC-limbic circuitry. Neuropharmacology. 2015 May; 92:116-24. PMID: 25637091; PMCID: PMC4346479.
    11. Chen MC, Ferrari L, Sacchet MD, Foland-Ross LC, Qiu MH, Gotlib IH, Fuller PM, Arrigoni E, Lu J. Identification of a direct GABAergic pallidocortical pathway in rodents. Eur J Neurosci. 2015 Mar; 41(6):748-59. PMID: 25581560; PMCID: PMC4363158.
    12. Gorman BR, Lu J, Baccei A, Lowry NC, Purvis JE, Mangoubi RS, Lerou PH. Multi-scale imaging and informatics pipeline for in situ pluripotent stem cell analysis. PLoS One. 2014; 9(12):e116037. PMID: 25551762; PMCID: PMC4281228.
    13. Gompf HS, Fuller PM, Hattar S, Saper CB, Lu J. Impaired circadian photosensitivity in mice lacking glutamate transmission from retinal melanopsin cells. J Biol Rhythms. 2015 Feb; 30(1):35-41. PMID: 25512304; PMCID: PMC4316665.
    14. Qiu MH, Yao QL, Vetrivelan R, Chen MC, Lu J. Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep. Cereb Cortex. 2016 Apr; 26(4):1430-9. PMID: 25316334; PMCID: PMC4785943 [Available on 04/01/17].
    15. Moskwa P, Zinn PO, Choi YE, Shukla SA, Fendler W, Chen CC, Lu J, Golub TR, Hjelmeland A, Chowdhury D. A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014 Dec; 12(12):1767-78. PMID: 25256711; PMCID: PMC4386891.
    16. Anaclet C, Ferrari L, Arrigoni E, Bass CE, Saper CB, Lu J, Fuller PM. The GABAergic parafacial zone is a medullary slow wave sleep-promoting center. Nat Neurosci. 2014 Sep; 17(9):1217-24. PMID: 25129078; PMCID: PMC4214681.
    17. Chang CH, Chen MC, Qiu MH, Lu J. Ventromedial prefrontal cortex regulates depressive-like behavior and rapid eye movement sleep in the rat. Neuropharmacology. 2014 Nov; 86:125-32. PMID: 25036609; PMCID: PMC4188719.
    18. Lu J, Li H, Hu M, Sasaki T, Baccei A, Gilbert DM, Liu JS, Collins JJ, Lerou PH. The distribution of genomic variations in human iPSCs is related to replication-timing reorganization during reprogramming. Cell Rep. 2014 Apr 10; 7(1):70-8. PMID: 24685138; PMCID: PMC4133748.
    19. Tan HK, Toh CX, Ma D, Yang B, Liu TM, Lu J, Wong CW, Tan TK, Li H, Syn C, Tan EL, Lim B, Lim YP, Cook SA, Loh YH. Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking. Stem Cells Transl Med. 2014 May; 3(5):586-98. PMID: 24646489; PMCID: PMC4006490.
    20. Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera MN, Lu J, Shioda T, Vasudevan S, Ramaswamy S, Maheswaran S, Diederichs S, Haber DA. The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes Dev. 2013 Dec 01; 27(23):2543-8. PMID: 24298054; PMCID: PMC3861668.
    21. Ramaligam V, Chen MC, Saper CB, Lu J. Perspectives on the rapid eye movement sleep switch in rapid eye movement sleep behavior disorder. Sleep Med. 2013 Aug; 14(8):707-13. PMID: 23768838; PMCID: PMC3776319.
    22. Chen MC, Yu H, Huang ZL, Lu J. Rapid eye movement sleep behavior disorder. Curr Opin Neurobiol. 2013 Oct; 23(5):793-8. PMID: 23518139; PMCID: PMC3750096.
    23. Anaclet C, Lin JS, Vetrivelan R, Krenzer M, Vong L, Fuller PM, Lu J. Identification and characterization of a sleep-active cell group in the rostral medullary brainstem. J Neurosci. 2012 Dec 12; 32(50):17970-6. PMID: 23238713; PMCID: PMC3564016.
    24. Vetrivelan R, Fuller PM, Yokota S, Lu J, Saper CB. Metabolic effects of chronic sleep restriction in rats. Sleep. 2012 Nov 01; 35(11):1511-20. PMID: 23115400; PMCID: PMC3466798.
    25. Krenzer M, Anaclet C, Vetrivelan R, Wang N, Vong L, Lowell BB, Fuller PM, Lu J. Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia. PLoS One. 2011; 6(10):e24998. PMID: 22043278; PMCID: PMC3197189.
    26. Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT, Wang XJ, Sano S, Prens EP, DiGiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE. Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis. PLoS One. 2011 Apr 04; 6(4):e18266. PMID: 21483750; PMCID: PMC3070727.
    27. Fuller PM, Fuller P, Sherman D, Pedersen NP, Saper CB, Lu J. Reassessment of the structural basis of the ascending arousal system. J Comp Neurol. 2011 Apr 01; 519(5):933-56. PMID: 21280045; PMCID: PMC3119596.
    28. Saper CB, Fuller PM, Pedersen NP, Lu J, Scammell TE. Sleep state switching. Neuron. 2010 Dec 22; 68(6):1023-42. PMID: 21172606; PMCID: PMC3026325.
    29. Vetrivelan R, Qiu MH, Chang C, Lu J. Role of Basal Ganglia in sleep-wake regulation: neural circuitry and clinical significance. Front Neuroanat. 2010; 4:145. PMID: 21151379; PMCID: PMC2996256.
    30. Gompf HS, Mathai C, Fuller PM, Wood DA, Pedersen NP, Saper CB, Lu J. Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment. J Neurosci. 2010 Oct 27; 30(43):14543-51. PMID: 20980612; PMCID: PMC2989851.
    31. Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT. MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14229-34. PMID: 20616003; PMCID: PMC2922532.
    32. Levy C, Khaled M, Robinson KC, Veguilla RA, Chen PH, Yokoyama S, Makino E, Lu J, Larue L, Beermann F, Chin L, Bosenberg M, Song JS, Fisher DE. Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell. 2010 Jun 11; 141(6):994-1005. PMID: 20550935; PMCID: PMC2897150.
    33. Qiu MH, Vetrivelan R, Fuller PM, Lu J. Basal ganglia control of sleep-wake behavior and cortical activation. Eur J Neurosci. 2010 Feb; 31(3):499-507. PMID: 20105243; PMCID: PMC3928571.
    34. Anaclet C, Pedersen NP, Fuller PM, Lu J. Brainstem circuitry regulating phasic activation of trigeminal motoneurons during REM sleep. PLoS One. 2010 Jan 20; 5(1):e8788. PMID: 20098748; PMCID: PMC2808333.
    35. Arrigoni E, Lu J, Vetrivelan R, Saper CB. Long-term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleus. Eur J Neurosci. 2009 Dec 03; 30(11):2112-20. PMID: 20128848; PMCID: PMC2819366.
    36. Fuller PM, Lu J, Saper CB. Standards of evidence in chronobiology: A response. J Circadian Rhythms. 2009 Jul 22; 7:9. PMID: 19624818; PMCID: PMC2724488.
    37. Vetrivelan R, Fuller PM, Tong Q, Lu J. Medullary circuitry regulating rapid eye movement sleep and motor atonia. J Neurosci. 2009 Jul 22; 29(29):9361-9. PMID: 19625526; PMCID: PMC2758912.
    38. Viswanathan SR, Mermel CH, Lu J, Lu CW, Golub TR, Daley GQ. microRNA expression during trophectoderm specification. PLoS One. 2009 Jul 03; 4(7):e6143. PMID: 19582159; PMCID: PMC2702083.
    39. Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, O'Sullivan M, Lu J, Phillips LA, Lockhart VL, Shah SP, Tanwar PS, Mermel CH, Beroukhim R, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PH, Daley GQ. Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009 Jul; 41(7):843-8. PMID: 19483683; PMCID: PMC2757943.
    40. Ikeda S, He A, Kong SW, Lu J, Bejar R, Bodyak N, Lee KH, Ma Q, Kang PM, Golub TR, Pu WT. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 2009 Apr; 29(8):2193-204. PMID: 19188439; PMCID: PMC2663304.
    41. Hartner JC, Walkley CR, Lu J, Orkin SH. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol. 2009 Jan; 10(1):109-15. PMID: 19060901; PMCID: PMC2701568.
    42. Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia. J Comp Neurol. 2008 Jun 01; 508(4):648-62. PMID: 18383504; PMCID: PMC4924624.
    43. Fuller PM, Lu J, Saper CB. Differential rescue of light- and food-entrainable circadian rhythms. Science. 2008 May 23; 320(5879):1074-7. PMID: 18497298; PMCID: PMC3489954.
    44. Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1949-54. PMID: 18238902; PMCID: PMC2538863.
    45. Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, Lu J, Qi HH, Wang W, Nickoloff JA, Wu C, Shi Y. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat Struct Mol Biol. 2007 Dec; 14(12):1165-72. PMID: 18026119; PMCID: PMC2754171.
    46. Fuller PM, Saper CB, Lu J. The pontine REM switch: past and present. J Physiol. 2007 Nov 01; 584(Pt 3):735-41. PMID: 17884926; PMCID: PMC2276987.
    47. Lu J, Meng W, Poy F, Maiti S, Goode BL, Eck MJ. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. J Mol Biol. 2007 Jun 22; 369(5):1258-69. PMID: 17482208; PMCID: PMC1939941.
    48. Srinivasan R, Zhou X, Miller E, Lu J, Lichtman J, Litchman J, Wong ST. Automated axon tracking of 3D confocal laser scanning microscopy images using guided probabilistic region merging. Neuroinformatics. 2007; 5(3):189-203. PMID: 17917130.
      View in: PubMed
    49. Lu J, Sherman D, Devor M, Saper CB. A putative flip-flop switch for control of REM sleep. Nature. 2006 Jun 01; 441(7093):589-94. PMID: 16688184.
      View in: PubMed
    50. Lu J, Greco MA. Sleep circuitry and the hypnotic mechanism of GABAA drugs. J Clin Sleep Med. 2006 Apr 15; 2(2):S19-26. PMID: 17557503.
      View in: PubMed
    51. Lu J, Jhou TC, Saper CB. Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter. J Neurosci. 2006 Jan 04; 26(1):193-202. PMID: 16399687.
      View in: PubMed
    52. Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005 Oct 27; 437(7063):1257-63. PMID: 16251950.
      View in: PubMed
    53. Saper CB, Lu J, Chou TC, Gooley J. The hypothalamic integrator for circadian rhythms. Trends Neurosci. 2005 Mar; 28(3):152-7. PMID: 15749169.
      View in: PubMed
    54. Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci. 2003 Nov 19; 23(33):10691-702. PMID: 14627654.
      View in: PubMed
    55. Zhang YH, Lu J, Elmquist JK, Saper CB. Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain. J Comp Neurol. 2003 Aug 11; 463(1):3-12. PMID: 12811798.
      View in: PubMed
    56. Gooley JJ, Lu J, Fischer D, Saper CB. A broad role for melanopsin in nonvisual photoreception. J Neurosci. 2003 Aug 06; 23(18):7093-106. PMID: 12904470.
      View in: PubMed
    57. Lu J, Bjorkum AA, Xu M, Gaus SE, Shiromani PJ, Saper CB. Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep. J Neurosci. 2002 Jun 01; 22(11):4568-76. PMID: 12040064.
      View in: PubMed
    58. Chou TC, Bjorkum AA, Gaus SE, Lu J, Scammell TE, Saper CB. Afferents to the ventrolateral preoptic nucleus. J Neurosci. 2002 Feb 01; 22(3):977-90. PMID: 11826126.
      View in: PubMed
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