"Proof of Concept Study" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An empirical investigation which pertains to the development of prototypes or models that demonstrate the feasibility of novel concepts, ideas, principles, schema or their practical application.
Descriptor ID 
D000075082

MeSH Number(s) 
H01.770.644.578

Concept/Terms 
Proof of Concept Study Proof of Concept Study
 Concept Study Proof
 Study Proof, Concept
 Proof of Concept Investigation
 Concept Investigation Proof
 Investigation Proof, Concept
 Proof of Concept Research
 Concept Research Proof
 Concept Research Proofs
 Research Proof, Concept
 Proof of Concept Testing
 Concept Testing Proof
 Concept Testing Proofs
 Testing Proof, Concept
 Testing Proofs, Concept
 Proof of Concept Experiment
 Concept Experiment Proof
 Concept Experiment Proofs
 Experiment Proof, Concept
 Proof of Concept Approach
 Approach Proof, Concept
 Approach Proofs, Concept
 Concept Approach Proof
 Concept Approach Proofs
 Proof of Concept Studies
Proof of Concept Prototype Proof of Concept Prototype
 Concept Prototype Proof
 Concept Prototype Proofs
 Prototype Proof, Concept
 Proof of Concept Model
 Concept Model Proof
 Concept Model Proofs
 Model Proof, Concept
Proof of Concept Evaluation Proof of Concept Evaluation
 Concept Evaluation Proof
 Concept Evaluation Proofs
 Evaluation Proof, Concept
 Proof of Concept Demonstration
 Concept Demonstration Proof
 Demonstration Proof, Concept

Below are MeSH descriptors whose meaning is more general than "Proof of Concept Study".
Below are MeSH descriptors whose meaning is more specific than "Proof of Concept Study".
This graph shows the total number of publications written about "Proof of Concept Study" by people in this website by year, and whether "Proof of Concept Study" was a major or minor topic of these publications.
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Year  Major Topic  Minor Topic  Total 

2016  1  1  2 
2018  0  1  1 
2019  0  1  1 
2020  0  2  2 
2021  0  1  1 
2022  0  1  1 
2023  0  1  1 
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Below are the most recent publications written about "Proof of Concept Study" by people in Profiles.

Perinatal Understanding of Mindful Awareness for Sleep (PUMAS): A singlearm proofofconcept clinical trial of a mindfulnessbased intervention for DSM5 insomnia disorder during pregnancy. Sleep Med. 2023 08; 108:7989.

Convolutional Neural Network Algorithm to Determine Lateralization of Seizure Onset in Patients With Epilepsy: A ProofofPrinciple Study. Neurology. 2023 07 18; 101(3):e324e335.

Proofofprinciple demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota. FASEB J. 2022 01; 36(1):e22043.

Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption. mBio. 2021 02 23; 12(1).

Peripheral serum metabolomic profiles inform central cognitive impairment. Sci Rep. 2020 08 20; 10(1):14059.

The Curing Coma Campaign: Framing Initial Scientific ChallengesProceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting. Neurocrit Care. 2020 08; 33(1):112.

Digital Cognitive Behavioral Therapy for Insomnia in Women With Chronic Migraines. Headache. 2020 05; 60(5):902915.

The left atrial appendage morphology is associated with embolic stroke subtypes using a simple classification system: A proof of concept study. J Cardiovasc Comput Tomogr. 2020 Jan  Feb; 14(1):2733.

Loss of bronchoprotection with ICS plus LABA treatment, ?receptor dynamics, and the effect of alendronate. J Allergy Clin Immunol. 2019 08; 144(2):416425.e7.

Alternative approaches to polyp extraction in colonoscopy: a?proof of principle study. Gastrointest Endosc. 2018 09; 88(3):536541.