 Botulinum Toxins
"Botulinum Toxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
| Descriptor ID |
D001905
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| MeSH Number(s) |
D08.811.277.656.300.480.153 D08.811.277.656.675.374.153 D12.776.097.156 D23.946.123.179
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| Concept/Terms |
Botulinum Toxins- Botulinum Toxins
- Toxins, Botulinum
- Botulinum Toxin
- Toxin, Botulinum
- Clostridium botulinum Toxins
- Toxins, Clostridium botulinum
- Botulin
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Below are MeSH descriptors whose meaning is more general than "Botulinum Toxins".
Below are MeSH descriptors whose meaning is more specific than "Botulinum Toxins".
This graph shows the total number of publications written about "Botulinum Toxins" by people in this website by year, and whether "Botulinum Toxins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 1992 | 3 | 0 | 3 | | 1993 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 2 | 0 | 2 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 1 | 2 | | 2006 | 3 | 0 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Botulinum Toxins" by people in Profiles.
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Kraimer KL, Husain I. Updated Medical and Surgical Treatment for Common Benign Laryngeal Lesions. Otolaryngol Clin North Am. 2019 Aug; 52(4):745-757.
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Comella CL. Systematic review of botulinum toxin treatment for oromandibular dystonia. Toxicon. 2018 Jun 01; 147:96-99.
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Jinnah HA, Comella CL, Perlmutter J, Lungu C, Hallett M. Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy? Toxicon. 2018 Jun 01; 147:89-95.
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Bledsoe IO, Comella CL. Botulinum Toxin Treatment of Cervical Dystonia. Semin Neurol. 2016 Feb; 36(1):47-53.
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Goldman JG. Writer's cramp. Toxicon. 2015 Dec 01; 107(Pt A):98-104.
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Eichenseer SR, Stebbins GT, Comella CL. Beyond a motor disorder: a prospective evaluation of sleep quality in cervical dystonia. Parkinsonism Relat Disord. 2014 Apr; 20(4):405-8.
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Ramirez-Castaneda J, Jankovic J, Comella C, Dashtipour K, Fernandez HH, Mari Z. Diffusion, spread, and migration of botulinum toxin. Mov Disord. 2013 Nov; 28(13):1775-83.
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Charous SJ, Comella CL, Fan W. Jaw-opening dystonia: Quality of life after botulinum toxin injections. Ear Nose Throat J. 2011 Feb; 90(2):E9.
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Hallett M, Benecke R, Blitzer A, Comella CL. Treatment of focal dystonias with botulinum neurotoxin. Toxicon. 2009 Oct; 54(5):628-33.
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Simpson DM, Blitzer A, Brashear A, Comella C, Dubinsky R, Hallett M, Jankovic J, Karp B, Ludlow CL, Miyasaki JM, Naumann M, So Y. Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2008 May 06; 70(19):1699-706.
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