Amyloid beta-Protein Precursor
"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
| Descriptor ID |
D016564
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| MeSH Number(s) |
D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
|
| Concept/Terms |
Amyloid beta-Protein Precursor- Amyloid beta-Protein Precursor
- Amyloid beta Protein Precursor
- beta-Protein Precursor, Amyloid
- Amyloid beta Precursor Protein
- Protease Nexin II
- Nexin II, Protease
- beta-Amyloid Protein Precursor
- beta Amyloid Protein Precursor
- Protease Nexin 2
- Nexin 2, Protease
- Amyloid A4 Protein Precursor
- Amyloid Protein Precursor
|
Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".
Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".
This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2016 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 2 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.
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Treadmill workout activates PPARa in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease. Brain Behav Immun. 2023 03; 109:204-218.
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FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease. Acta Neuropathol. 2022 07; 144(1):59-79.
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Role of Retinoid X Receptors (RXRs) and dietary vitamin A in Alzheimer's disease: Evidence from clinicopathological and preclinical studies. Neurobiol Dis. 2021 12; 161:105542.
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Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021 07 27; 9(1):129.
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A? (Amyloid Beta) and Tau Tangle Pathology Modifies the Association Between Small Vessel Disease and Cortical Microinfarcts. Stroke. 2021 03; 52(3):1012-1021.
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DNA methylation analysis of candidate genes associated with dementia in peripheral blood. Epigenomics. 2020 12; 12(23):2109-2123.
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Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models. Brain Pathol. 2019 07; 29(4):485-501.
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Soluble Conformers of A? and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci. 2016 09 14; 36(37):9647-58.
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Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased A? generation in Alzheimer's disease. Acta Neuropathol. 2016 08; 132(2):235-256.
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Activation of peroxisome proliferator-activated receptor a stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8445-50.