"PPAR alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
| Descriptor ID |
D047493
|
| MeSH Number(s) |
D12.776.826.239.500
|
| Concept/Terms |
PPAR alpha- PPAR alpha
- Peroxisome Proliferator-Activated Receptor alpha
- Peroxisome Proliferator Activated Receptor alpha
- PPARalpha
|
Below are MeSH descriptors whose meaning is more general than "PPAR alpha".
Below are MeSH descriptors whose meaning is more specific than "PPAR alpha".
This graph shows the total number of publications written about "PPAR alpha" by people in this website by year, and whether "PPAR alpha" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 5 | 0 | 5 |
| 2016 | 1 | 0 | 1 |
| 2018 | 3 | 0 | 3 |
| 2019 | 6 | 0 | 6 |
| 2020 | 1 | 0 | 1 |
| 2021 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
| 2023 | 2 | 2 | 4 |
To return to the timeline,
click here.
Below are the most recent publications written about "PPAR alpha" by people in Profiles.
-
Lipid-Lowering Drug Gemfibrozil Protects Mice from Tay-Sachs Disease via Peroxisome Proliferator-Activated Receptor a. Cells. 2023 Dec 08; 12(24).
-
Muscle-building supplement ?-hydroxy ?-methylbutyrate binds to PPARa to improve hippocampal functions in mice. Cell Rep. 2023 07 25; 42(7):112717.
-
Activation of PPARa Exhibits Therapeutic Efficacy in a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis. J Neurosci. 2023 03 08; 43(10):1814-1829.
-
Treadmill workout activates PPARa in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease. Brain Behav Immun. 2023 03; 109:204-218.
-
Treadmill exercise reduces a-synuclein spreading via PPARa. Cell Rep. 2022 07 12; 40(2):111058.
-
Activation of PPARa enhances astroglial uptake and degradation of ?-amyloid. Sci Signal. 2021 Oct 26; 14(706):eabg4747.
-
Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARa-Dependent Astrocytic GDNF Pathway. J Neurosci. 2021 03 10; 41(10):2287-2300.
-
Oleamide, a Sleep-Inducing Supplement, Upregulates Doublecortin in Hippocampal Progenitor Cells via PPARa. J Alzheimers Dis. 2021; 84(4):1747-1762.
-
Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARa. JCI Insight. 2020 05 21; 5(10).
-
PPARa serves as a new receptor of aspirin for neuroprotection. J Neurosci Res. 2020 04; 98(4):626-631.