 PPAR alpha
"PPAR alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
| Descriptor ID |
D047493
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| MeSH Number(s) |
D12.776.260.698.239.500 D12.776.826.239.500 D12.776.930.669.239.500
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| Concept/Terms |
PPAR alpha- PPAR alpha
- PPARalpha
- Peroxisome Proliferator-Activated Receptor alpha
- Peroxisome Proliferator Activated Receptor alpha
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Below are MeSH descriptors whose meaning is more general than "PPAR alpha".
Below are MeSH descriptors whose meaning is more specific than "PPAR alpha".
This graph shows the total number of publications written about "PPAR alpha" by people in this website by year, and whether "PPAR alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 1 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 5 | 0 | 5 | | 2016 | 1 | 0 | 1 | | 2018 | 3 | 0 | 3 | | 2019 | 4 | 0 | 4 |
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Below are the most recent publications written about "PPAR alpha" by people in Profiles.
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Chakrabarti S, Roy A, Prorok T, Patel D, Dasarathi S, Pahan K. Aspirin up-regulates suppressor of cytokine signaling 3 in glial cells via PPARa. J Neurochem. 2019 10; 151(1):50-63.
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Gottschalk CG, Roy A, Jana M, Kundu M, Pahan K. Activation of Peroxisome Proliferator-Activated Receptor-a Increases the Expression of Nuclear Receptor Related 1 Protein (Nurr1) in Dopaminergic Neurons. Mol Neurobiol. 2019 Nov; 56(11):7872-7887.
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Chakrabarti S, Chandra S, Roy A, Dasarathi S, Kundu M, Pahan K. Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARa: Implications for late-infantile Batten disease therapy. Neurobiol Dis. 2019 07; 127:362-373.
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Prorok T, Jana M, Patel D, Pahan K. Cinnamic Acid Protects the Nigrostriatum in a Mouse Model of Parkinson's Disease via Peroxisome Proliferator-Activated Receptora. Neurochem Res. 2019 Apr; 44(4):751-762.
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Chandra S, Roy A, Jana M, Pahan K. Cinnamic acid activates PPARa to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model. Neurobiol Dis. 2019 04; 124:379-395.
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Patel D, Roy A, Kundu M, Jana M, Luan CH, Gonzalez FJ, Pahan K. Aspirin binds to PPARa to stimulate hippocampal plasticity and protect memory. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):E7408-E7417.
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Chandra S, Jana M, Pahan K. Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARa. J Neurosci. 2018 07 25; 38(30):6682-6699.
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Roy A, Kundu M, Jana M, Mishra RK, Yung Y, Luan CH, Gonzalez FJ, Pahan K. Identification and characterization of PPARa ligands in the hippocampus. Nat Chem Biol. 2016 Dec; 12(12):1075-1083.
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Ghosh A, Pahan K. PPARa in lysosomal biogenesis: A perspective. Pharmacol Res. 2016 Jan; 103:144-8.
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Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, Luan CH, Gonzalez FJ, Pahan K. HMG-CoA Reductase Inhibitors Bind to PPARa to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice. Cell Metab. 2015 Aug 04; 22(2):253-65.
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