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Eunsil Hahm

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Nephrology
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    My Scopus ID is 6603611508.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020 01; 21(1):30-41. PMID: 31819254.
      View in: PubMed
    2. Koh KH, Cao Y, Mangos S, Tardi NJ, Dande RR, Lee HW, Samelko B, Altintas MM, Schmitz VP, Lee H, Mukherjee K, Peev V, Cimbaluk DJ, Reiser J, Hahm E. Nonimmune cell-derived ICOS ligand functions as a renoprotective avß3 integrin-selective antagonist. J Clin Invest. 2019 04 01; 129(4):1713-1726. PMID: 30747722.
      View in: PubMed
    3. Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J. A tripartite complex of suPAR, APOL1 risk variants and avß3 integrin on podocytes mediates chronic kidney disease. Nat Med. 2017 Aug; 23(8):945-953. PMID: 28650456.
      View in: PubMed
    4. Gupta KH, Goldufsky JW, Wood SJ, Tardi NJ, Moorthy GS, Gilbert DZ, Zayas JP, Hahm E, Altintas MM, Reiser J, Shafikhani SH. Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles. Dev Cell. 2017 06 19; 41(6):674-684.e5. PMID: 28633020.
      View in: PubMed
    5. Lee KE, Hahm E, Bae S, Kang JS, Lee WJ. The enhanced tumor inhibitory effects of gefitinib and L-ascorbic acid combination therapy in non-small cell lung cancer cells. Oncol Lett. 2017 Jul; 14(1):276-282. PMID: 28693165.
      View in: PubMed
    6. Vyas AR, Moura MB, Hahm ER, Singh KB, Singh SV. Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits. J Cell Biochem. 2016 11; 117(11):2482-95. PMID: 26990292.
      View in: PubMed
    7. Kim SH, Hahm ER, Arlotti JA, Samanta SK, Moura MB, Thorne SH, Shuai Y, Anderson CJ, White AG, Lokshin A, Lee J, Singh SV. Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown. Breast Cancer Res Treat. 2016 05; 157(1):41-54. PMID: 27097807.
      View in: PubMed
    8. Hahm ER, Sakao K, Singh SV. Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells. Prostate. 2014 Sep; 74(12):1209-21. PMID: 25043291.
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    9. Li J, Kim K, Hahm E, Molokie R, Hay N, Gordeuk VR, Du X, Cho J. Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest. 2014 Apr; 124(4):1483-96. PMID: 24642468.
      View in: PubMed
    10. Hahm ER, Singh SV. Diallyl trisulfide inhibits estrogen receptor-a activity in human breast cancer cells. Breast Cancer Res Treat. 2014 Feb; 144(1):47-57. PMID: 24487688.
      View in: PubMed
    11. Antony ML, Lee J, Hahm ER, Kim SH, Marcus AI, Kumari V, Ji X, Yang Z, Vowell CL, Wipf P, Uechi GT, Yates NA, Romero G, Sarkar SN, Singh SV. Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of ß-tubulin. J Biol Chem. 2014 Jan 17; 289(3):1852-65. PMID: 24297176.
      View in: PubMed
    12. Hahm ER, Lee J, Singh SV. Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells. Mol Carcinog. 2014 Nov; 53(11):907-16. PMID: 24019090.
      View in: PubMed
    13. Kim K, Hahm E, Li J, Holbrook LM, Sasikumar P, Stanley RG, Ushio-Fukai M, Gibbins JM, Cho J. Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice. Blood. 2013 Aug 08; 122(6):1052-61. PMID: 23788140.
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    14. Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J. Extracellular protein disulfide isomerase regulates ligand-binding activity of aMß2 integrin and neutrophil recruitment during vascular inflammation. Blood. 2013 May 09; 121(19):3789-800, S1-15. PMID: 23460613.
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    15. Hahm ER, Moura MB, Kelley EE, Van Houten B, Shiva S, Singh SV. Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species. PLoS One. 2011; 6(8):e23354. PMID: 21853114.
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    16. Lu SJ, Li F, Yin H, Feng Q, Kimbrel EA, Hahm E, Thon JN, Wang W, Italiano JE, Cho J, Lanza R. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res. 2011 Mar; 21(3):530-45. PMID: 21221130.
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    17. Xiao D, Powolny AA, Antosiewicz J, Hahm ER, Bommareddy A, Zeng Y, Desai D, Amin S, Herman-Antosiewicz A, Singh SV. Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species. Pharm Res. 2009 Jul; 26(7):1729-38. PMID: 19384467.
      View in: PubMed
    18. Xiao D, Zeng Y, Hahm ER, Kim YA, Ramalingam S, Singh SV. Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells. Environ Mol Mutagen. 2009 Apr; 50(3):201-12. PMID: 18800351.
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    19. Lee SK, Kang JS, Jung DJ, Hur DY, Kim JE, Hahm E, Bae S, Kim HW, Kim D, Cho BJ, Cho D, Shin DH, Hwang YI, Lee WJ. Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production. J Cell Physiol. 2008 Jul; 216(1):180-8. PMID: 18297687.
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    20. Hahm E, Jin DH, Kang JS, Kim YI, Hong SW, Lee SK, Kim HN, Jung DJ, Kim JE, Shin DH, Hwang YI, Kim YS, Hur DY, Yang Y, Cho D, Lee MS, Lee WJ. The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma. J Cell Biochem. 2007 Nov 01; 102(4):1002-10. PMID: 17455238.
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    21. Kim YS, Park GB, Song HK, Hur I, Lee HK, Kang JS, Hahm E, Lee WJ, Hur DY. Cross-linking of CD54 on Burkitt lymphoma cell line Raji and Ramos induces FasL expression by reactive oxygen species and apoptosis of adjacent cells in Fas/FasL interaction. J Immunother. 2007 Oct; 30(7):727-39. PMID: 17893565.
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    22. Xiao H, Rawal M, Hahm ER, Singh SV. Benzo[a]pyrene-7,8-diol-9,10-epoxide causes caspase-mediated apoptosis in H460 human lung cancer cell line. Cell Cycle. 2007 Nov 15; 6(22):2826-34. PMID: 17986867.
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    23. Singh SV, Choi S, Zeng Y, Hahm ER, Xiao D. Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. Cancer Res. 2007 Aug 01; 67(15):7439-49. PMID: 17671214.
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    24. Lee YS, Shin S, Shigihara T, Hahm E, Liu MJ, Han J, Yoon JW, Jun HS. Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis. Diabetes. 2007 Jun; 56(6):1671-9. PMID: 17369525.
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    25. Xiao D, Lew KL, Kim YA, Zeng Y, Hahm ER, Dhir R, Singh SV. Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction. Clin Cancer Res. 2006 Nov 15; 12(22):6836-43. PMID: 17121905.
      View in: PubMed
    26. Hwang YH, Lee JW, Hahm ER, Jung KC, Lee JH, Park CH, Rhee HS, Ryu JM, Kim HK, Yang CH. Momordin I, an inhibitor of AP-1, suppressed osteoclastogenesis through inhibition of NF-kappaB and AP-1 and also reduced osteoclast activity and survival. Biochem Biophys Res Commun. 2005 Nov 25; 337(3):815-23. PMID: 16213465.
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    27. Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake. J Cell Physiol. 2005 Jul; 204(1):192-7. PMID: 15672419.
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    28. Park CH, Hahm ER, Lee JH, Jung KC, Yang CH. Inhibition of beta-catenin-mediated transactivation by flavanone in AGS gastric cancer cells. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):1222-8. PMID: 15883006.
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    29. Park CH, Hahm ER, Lee JH, Jung KC, Rhee HS, Yang CH. Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line. Carcinogenesis. 2005 Nov; 26(11):1929-33. PMID: 15930030.
      View in: PubMed
    30. Park CH, Chang JY, Hahm ER, Park S, Kim HK, Yang CH. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun. 2005 Mar 04; 328(1):227-34. PMID: 15670774.
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    31. Han SS, Kim K, Hahm ER, Park CH, Kimler BF, Lee SJ, Lee SH, Kim WS, Jung CW, Park K, Kim J, Yoon SS, Lee JH, Park S. Arsenic trioxide represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. J Cell Biochem. 2005 Mar 01; 94(4):695-707. PMID: 15547942.
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    32. Park S, Park CH, Hahm ER, Kim K, Kimler BF, Lee SJ, Park HK, Lee SH, Kim WS, Jung CW, Park K, Riordan HD, Lee JH. Activation of Raf1 and the ERK pathway in response to l-ascorbic acid in acute myeloid leukemia cells. Cell Signal. 2005 Jan; 17(1):111-9. PMID: 15451031.
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    33. Yang Y, Hahm E, Kim Y, Kang J, Lee W, Han I, Myung P, Kang H, Park H, Cho D. Regulation of IL-18 expression by CRH in mouse microglial cells. Immunol Lett. 2005 May 15; 98(2):291-6. PMID: 15860230.
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    34. Park S, Han SS, Park CH, Hahm ER, Lee SJ, Park HK, Lee SH, Kim WS, Jung CW, Park K, Riordan HD, Kimler BF, Kim K, Lee JH. L-Ascorbic acid induces apoptosis in acute myeloid leukemia cells via hydrogen peroxide-mediated mechanisms. Int J Biochem Cell Biol. 2004 Nov; 36(11):2180-95. PMID: 15313465.
      View in: PubMed
    35. Han SS, Kim K, Hahm ER, Lee SJ, Surh YJ, Park HK, Kim WS, Jung CW, Lee MH, Park K, Yang JH, Yoon SS, Riordan NH, Riordan HD, Kimler BF, Park CH, Lee JH, Park S. L-ascorbic acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. J Cell Biochem. 2004 Oct 01; 93(2):257-70. PMID: 15368354.
      View in: PubMed
    36. Cho D, Kim YI, Kang JS, Hahm E, Yang Y, Kim D, Kim S, Kim YS, Hur D, Park H, Hwang YI, Kim TS, Lee WJ. Resistance to cytotoxic chemotherapy is induced by NK cells in non-Hodgkin's Lymphoma Cells. J Clin Immunol. 2004 Sep; 24(5):553-60. PMID: 15359114.
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    37. Hahm ER, Gho YS, Park S, Park C, Kim KW, Yang CH. Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis. Biochem Biophys Res Commun. 2004 Aug 20; 321(2):337-44. PMID: 15358181.
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    38. Park S, Hahm ER, Lee DK, Yang CH. Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells. J Cell Biochem. 2004 Apr 01; 91(5):973-86. PMID: 15034932.
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    39. Park S, Chung S, Kim KM, Jung KC, Park C, Hahm ER, Yang CH. Determination of binding constant of transcription factor myc-max/max-max and E-box DNA: the effect of inhibitors on the binding. Biochim Biophys Acta. 2004 Feb 24; 1670(3):217-28. PMID: 14980448.
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    40. Cho D, Hahm E, Kang JS, Kim YI, Yang Y, Park JH, Kim D, Kim S, Kim YS, Hur D, Park H, Pang S, Hwang YI, Lee WJ. Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells. Melanoma Res. 2003 Dec; 13(6):549-54. PMID: 14646616.
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    41. Kang JS, Cho D, Kim YI, Hahm E, Yang Y, Kim D, Hur D, Park H, Bang S, Hwang YI, Lee WJ. L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway. Cancer Immunol Immunother. 2003 Nov; 52(11):693-8. PMID: 12827307.
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    42. Cho D, Seung Kang J, Hoon Park J, Kim YI, Hahm E, Lee J, Yang Y, Jeon J, Song H, Park H, Kim T, Pang S, Kim CW, Il Hwang Y, Jae Lee W. The enhanced IL-18 production by UVB irradiation requires ROI and AP-1 signaling in human keratinocyte cell line (HaCaT). Biochem Biophys Res Commun. 2002 Oct 25; 298(2):289-95. PMID: 12387830.
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    43. Kim D, Hur DY, Kim YS, Lee K, Lee Y, Cho D, Kang JS, Kim YI, Hahm E, Yang Y, Yoon S, Kim S, Lee WB, Park HY, Kim YB, Hwang YI, Chang KY, Lee WJ. CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner in Raji cells. Hum Immunol. 2002 Jul; 63(7):576-87. PMID: 12072193.
      View in: PubMed
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