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Eunsil Hahm

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Nephrology
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    My Scopus ID is 6603611508.


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Peev V, Hahm E, Reiser J. Unwinding focal segmental glomerulosclerosis. F1000Res. 2017; 6:466. PMID: 28491286.
      View in: PubMed
    2. Vyas AR, Moura MB, Hahm ER, Singh KB, Singh SV. Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits. J Cell Biochem. 2016 Nov; 117(11):2482-95. PMID: 26990292; PMCID: PMC5014708 [Available on 11/01/17].
    3. Hahm ER, Sakao K, Singh SV. Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells. Prostate. 2014 Sep; 74(12):1209-21. PMID: 25043291; PMCID: PMC4156520.
    4. Li J, Kim K, Hahm E, Molokie R, Hay N, Gordeuk VR, Du X, Cho J. Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest. 2014 Apr; 124(4):1483-96. PMID: 24642468; PMCID: PMC3973084.
    5. Hahm ER, Singh SV. Diallyl trisulfide inhibits estrogen receptor-a activity in human breast cancer cells. Breast Cancer Res Treat. 2014 Feb; 144(1):47-57. PMID: 24487688; PMCID: PMC3941172.
    6. Antony ML, Lee J, Hahm ER, Kim SH, Marcus AI, Kumari V, Ji X, Yang Z, Vowell CL, Wipf P, Uechi GT, Yates NA, Romero G, Sarkar SN, Singh SV. Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of ß-tubulin. J Biol Chem. 2014 Jan 17; 289(3):1852-65. PMID: 24297176; PMCID: PMC3894360.
    7. Tailor D, Hahm ER, Kale RK, Singh SV, Singh RP. Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells. Mitochondrion. 2014 May; 16:55-64. PMID: 24177748; PMCID: PMC4004730.
    8. Hahm ER, Lee J, Singh SV. Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells. Mol Carcinog. 2014 Nov; 53(11):907-16. PMID: 24019090; PMCID: PMC3859703.
    9. Kim K, Hahm E, Li J, Holbrook LM, Sasikumar P, Stanley RG, Ushio-Fukai M, Gibbins JM, Cho J. Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice. Blood. 2013 Aug 08; 122(6):1052-61. PMID: 23788140; PMCID: PMC3739031.
    10. Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J. Extracellular protein disulfide isomerase regulates ligand-binding activity of aMß2 integrin and neutrophil recruitment during vascular inflammation. Blood. 2013 May 09; 121(19):3789-800, S1-15. PMID: 23460613; PMCID: PMC3650702.
    11. Hahm ER, Moura MB, Kelley EE, Van Houten B, Shiva S, Singh SV. Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species. PLoS One. 2011; 6(8):e23354. PMID: 21853114; PMCID: PMC3154436.
    12. Lu SJ, Li F, Yin H, Feng Q, Kimbrel EA, Hahm E, Thon JN, Wang W, Italiano JE, Cho J, Lanza R. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res. 2011 Mar; 21(3):530-45. PMID: 21221130; PMCID: PMC3193430.
    13. Xiao D, Powolny AA, Moura MB, Kelley EE, Bommareddy A, Kim SH, Hahm ER, Normolle D, Van Houten B, Singh SV. Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells. J Biol Chem. 2010 Aug 20; 285(34):26558-69. PMID: 20571029; PMCID: PMC2924093.
    14. Hahm ER, Singh SV. Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells. Cancer Prev Res (Phila). 2010 Apr; 3(4):484-94. PMID: 20233902; PMCID: PMC2853726.
    15. Xiao D, Powolny AA, Antosiewicz J, Hahm ER, Bommareddy A, Zeng Y, Desai D, Amin S, Herman-Antosiewicz A, Singh SV. Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species. Pharm Res. 2009 Jul; 26(7):1729-38. PMID: 19384467; PMCID: PMC2744077.
    16. Xiao D, Zeng Y, Hahm ER, Kim YA, Ramalingam S, Singh SV. Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells. Environ Mol Mutagen. 2009 Apr; 50(3):201-12. PMID: 18800351; PMCID: PMC2656596.
    17. Stan SD, Hahm ER, Warin R, Singh SV. Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Res. 2008 Sep 15; 68(18):7661-9. PMID: 18794155; PMCID: PMC2562581.
    18. Lee SK, Kang JS, Jung DJ, Hur DY, Kim JE, Hahm E, Bae S, Kim HW, Kim D, Cho BJ, Cho D, Shin DH, Hwang YI, Lee WJ. Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production. J Cell Physiol. 2008 Jul; 216(1):180-8. PMID: 18297687.
      View in: PubMed
    19. Hahm E, Jin DH, Kang JS, Kim YI, Hong SW, Lee SK, Kim HN, Jung DJ, Kim JE, Shin DH, Hwang YI, Kim YS, Hur DY, Yang Y, Cho D, Lee MS, Lee WJ. The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma. J Cell Biochem. 2007 Nov 01; 102(4):1002-10. PMID: 17455238.
      View in: PubMed
    20. Kim YS, Park GB, Song HK, Hur I, Lee HK, Kang JS, Hahm E, Lee WJ, Hur DY. Cross-linking of CD54 on Burkitt lymphoma cell line Raji and Ramos induces FasL expression by reactive oxygen species and apoptosis of adjacent cells in Fas/FasL interaction. J Immunother. 2007 Oct; 30(7):727-39. PMID: 17893565.
      View in: PubMed
    21. Hahm ER, Singh SV. Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity. Mol Cancer Ther. 2007 Oct; 6(10):2686-95. PMID: 17938262.
      View in: PubMed
    22. Xiao H, Rawal M, Hahm ER, Singh SV. Benzo[a]pyrene-7,8-diol-9,10-epoxide causes caspase-mediated apoptosis in H460 human lung cancer cell line. Cell Cycle. 2007 Nov 15; 6(22):2826-34. PMID: 17986867.
      View in: PubMed
    23. Singh SV, Choi S, Zeng Y, Hahm ER, Xiao D. Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. Cancer Res. 2007 Aug 01; 67(15):7439-49. PMID: 17671214.
      View in: PubMed
    24. Lee YS, Shin S, Shigihara T, Hahm E, Liu MJ, Han J, Yoon JW, Jun HS. Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis. Diabetes. 2007 Jun; 56(6):1671-9. PMID: 17369525.
      View in: PubMed
    25. Xiao D, Lew KL, Kim YA, Zeng Y, Hahm ER, Dhir R, Singh SV. Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction. Clin Cancer Res. 2006 Nov 15; 12(22):6836-43. PMID: 17121905.
      View in: PubMed
    26. Hwang YH, Lee JW, Hahm ER, Jung KC, Lee JH, Park CH, Rhee HS, Ryu JM, Kim HK, Yang CH. Momordin I, an inhibitor of AP-1, suppressed osteoclastogenesis through inhibition of NF-kappaB and AP-1 and also reduced osteoclast activity and survival. Biochem Biophys Res Commun. 2005 Nov 25; 337(3):815-23. PMID: 16213465.
      View in: PubMed
    27. Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake. J Cell Physiol. 2005 Jul; 204(1):192-7. PMID: 15672419.
      View in: PubMed
    28. Park CH, Hahm ER, Lee JH, Jung KC, Yang CH. Inhibition of beta-catenin-mediated transactivation by flavanone in AGS gastric cancer cells. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):1222-8. PMID: 15883006.
      View in: PubMed
    29. Park CH, Hahm ER, Lee JH, Jung KC, Rhee HS, Yang CH. Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line. Carcinogenesis. 2005 Nov; 26(11):1929-33. PMID: 15930030.
      View in: PubMed
    30. Park CH, Chang JY, Hahm ER, Park S, Kim HK, Yang CH. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun. 2005 Mar 04; 328(1):227-34. PMID: 15670774.
      View in: PubMed
    31. Han SS, Kim K, Hahm ER, Park CH, Kimler BF, Lee SJ, Lee SH, Kim WS, Jung CW, Park K, Kim J, Yoon SS, Lee JH, Park S. Arsenic trioxide represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. J Cell Biochem. 2005 Mar 01; 94(4):695-707. PMID: 15547942.
      View in: PubMed
    32. Park S, Park CH, Hahm ER, Kim K, Kimler BF, Lee SJ, Park HK, Lee SH, Kim WS, Jung CW, Park K, Riordan HD, Lee JH. Activation of Raf1 and the ERK pathway in response to l-ascorbic acid in acute myeloid leukemia cells. Cell Signal. 2005 Jan; 17(1):111-9. PMID: 15451031.
      View in: PubMed
    33. Yang Y, Hahm E, Kim Y, Kang J, Lee W, Han I, Myung P, Kang H, Park H, Cho D. Regulation of IL-18 expression by CRH in mouse microglial cells. Immunol Lett. 2005 May 15; 98(2):291-6. PMID: 15860230.
      View in: PubMed
    34. Park S, Han SS, Park CH, Hahm ER, Lee SJ, Park HK, Lee SH, Kim WS, Jung CW, Park K, Riordan HD, Kimler BF, Kim K, Lee JH. L-Ascorbic acid induces apoptosis in acute myeloid leukemia cells via hydrogen peroxide-mediated mechanisms. Int J Biochem Cell Biol. 2004 Nov; 36(11):2180-95. PMID: 15313465.
      View in: PubMed
    35. Han SS, Kim K, Hahm ER, Lee SJ, Surh YJ, Park HK, Kim WS, Jung CW, Lee MH, Park K, Yang JH, Yoon SS, Riordan NH, Riordan HD, Kimler BF, Park CH, Lee JH, Park S. L-ascorbic acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. J Cell Biochem. 2004 Oct 01; 93(2):257-70. PMID: 15368354.
      View in: PubMed
    36. Cho D, Kim YI, Kang JS, Hahm E, Yang Y, Kim D, Kim S, Kim YS, Hur D, Park H, Hwang YI, Kim TS, Lee WJ. Resistance to cytotoxic chemotherapy is induced by NK cells in non-Hodgkin's Lymphoma Cells. J Clin Immunol. 2004 Sep; 24(5):553-60. PMID: 15359114.
      View in: PubMed
    37. Hahm ER, Gho YS, Park S, Park C, Kim KW, Yang CH. Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis. Biochem Biophys Res Commun. 2004 Aug 20; 321(2):337-44. PMID: 15358181.
      View in: PubMed
    38. Park S, Hahm ER, Lee DK, Yang CH. Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells. J Cell Biochem. 2004 Apr 01; 91(5):973-86. PMID: 15034932.
      View in: PubMed
    39. Park S, Chung S, Kim KM, Jung KC, Park C, Hahm ER, Yang CH. Determination of binding constant of transcription factor myc-max/max-max and E-box DNA: the effect of inhibitors on the binding. Biochim Biophys Acta. 2004 Feb 24; 1670(3):217-28. PMID: 14980448.
      View in: PubMed
    40. Hahm ER, Park S, Yang CH. 7, 8-dihydroxyflavanone as an inhibitor for Jun-Fos-DNA complex formation and its cytotoxic effect on cultured human cancer cells. Nat Prod Res. 2003 Dec; 17(6):431-6. PMID: 14577694.
      View in: PubMed
    41. Cho D, Hahm E, Kang JS, Kim YI, Yang Y, Park JH, Kim D, Kim S, Kim YS, Hur D, Park H, Pang S, Hwang YI, Lee WJ. Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells. Melanoma Res. 2003 Dec; 13(6):549-54. PMID: 14646616.
      View in: PubMed
    42. Kang JS, Cho D, Kim YI, Hahm E, Yang Y, Kim D, Hur D, Park H, Bang S, Hwang YI, Lee WJ. L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway. Cancer Immunol Immunother. 2003 Nov; 52(11):693-8. PMID: 12827307.
      View in: PubMed
    43. Cho D, Seung Kang J, Hoon Park J, Kim YI, Hahm E, Lee J, Yang Y, Jeon J, Song H, Park H, Kim T, Pang S, Kim CW, Il Hwang Y, Jae Lee W. The enhanced IL-18 production by UVB irradiation requires ROI and AP-1 signaling in human keratinocyte cell line (HaCaT). Biochem Biophys Res Commun. 2002 Oct 25; 298(2):289-95. PMID: 12387830.
      View in: PubMed
    44. Hahm ER, Cheon G, Lee J, Kim B, Park C, Yang CH. New and known symmetrical curcumin derivatives inhibit the formation of Fos-Jun-DNA complex. Cancer Lett. 2002 Oct 08; 184(1):89-96. PMID: 12104052.
      View in: PubMed
    45. Kim D, Hur DY, Kim YS, Lee K, Lee Y, Cho D, Kang JS, Kim YI, Hahm E, Yang Y, Yoon S, Kim S, Lee WB, Park HY, Kim YB, Hwang YI, Chang KY, Lee WJ. CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner in Raji cells. Hum Immunol. 2002 Jul; 63(7):576-87. PMID: 12072193.
      View in: PubMed
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