Profiles

Keywords
Last Name
Institution

Jeffrey Kordower

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentNeurology Research
Address1735 W. Harrison St
Chicago IL 60612
Phone312-563-3584
vCardDownload vCard
    Other Positions
    TitleProfessor
    InstitutionRush University, Rush Medical College
    DepartmentNeurological Sciences


    Collapse Overview 
    Collapse overview
    Other Appointments:
    Director, Section of Neurobiology

    Overview:
    Kordower is an international authority in the area of movement disorders with special expertise in pathophysiology and experimental therapeutic strategies in Parkinson’s disease, Alzheimer’s disease and Huntington’s disease — especially using nonhuman primate models. He has published landmark papers in the area of cell replacement strategies, including the first demonstration that fetal dopaminergic grafts can survive, innervate and form synapses in patients with Parkinson’s disease that was published in the New England Journal of Medicine. His recent demonstration that long-term grafts in such patients can form Lewy bodies was recently published in Nature Medicine.

    Kordower has published seminal studies including the lead article in Science demonstrating that gene delivery of the trophic factors GDNF and neurturin can prevent the emergence of motor symptoms and nigrostriatal degeneration in a monkey model of PD. He also was the first to demonstrate that gene delivery of trophic factors can obviate neurodegenerative processes in nonhuman primate models of Huntington’s disease and Alzheimer’s disease, with these studies being published in Nature and The Journal of Comparative Neurology, respectively.

    He has published numerous papers investigating the role of misfolded proteins in PD pathogenesis. These include papers in human and experimental PD on the role of alpha synuclein misfolding on Nurr1 and dopamine expression, lysosome and proteasome dysfunction, and axonal transport defects. He is a co-author on the landmark Nature paper lead by the Studer group demonstrating the structural and functional efficacy of dopaminergic human stem cells in rodent and nonhuman primate models of PD. In addition, he is collaborating with Trojanowski and Lee and recently demonstrated the ability of preformed fibrils to be transported in nonhuman primates and cause degeneration in nonhuman primates, a study that serves as the foundation of the current application.

    Kordower has published over 350 papers, has lectured all over the world, has been on over 20 editorial boards, and is on the SAB’s of many biotech companies and scientific organizations. He is a past councilor and past president of the American Society for Neural Transplantation, past chair for the Committee for the Use of Animals for SFN, and is a founding SAB member for the Michael J. Fox Foundation and is a past member of their Executive SAB.

    My Scopus ID is 7005337450.
    My NIH COMMONS name is JKORDOWER.

    Education
    PhD, Queens College, City University of New York
    MA, Queens College, City University of New York
    BA, Queens College, City University of New York


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Obeso JA, Stamelou M, Goetz CG, Poewe W, Lang AE, Weintraub D, Burn D, Halliday GM, Bezard E, Przedborski S, Lehericy S, Brooks DJ, Rothwell JC, Hallett M, DeLong MR, Marras C, Tanner CM, Ross GW, Langston JW, Klein C, Bonifati V, Jankovic J, Lozano AM, Deuschl G, Bergman H, Tolosa E, Rodriguez-Violante M, Fahn S, Postuma RB, Berg D, Marek K, Standaert DG, Surmeier DJ, Olanow CW, Kordower JH, Calabresi P, Schapira AHV, Stoessl AJ. Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy. Mov Disord. 2017 Sep; 32(9):1264-1310. PMID: 28887905.
      View in: PubMed
    2. Mandel RJ, Marmion DJ, Kirik D, Chu Y, Heindel C, McCown T, Gray SJ, Kordower JH. Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates. Acta Neuropathol Commun. 2017 Jun 16; 5(1):47. PMID: 28619074.
      View in: PubMed
    3. Wakeman DR, Hiller BM, Marmion DJ, McMahon CW, Corbett GT, Mangan KP, Ma J, Little LE, Xie Z, Perez-Rosello T, Guzman JN, Surmeier DJ, Kordower JH. Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo. Stem Cell Reports. 2017 Jul 11; 9(1):149-161. PMID: 28579395.
      View in: PubMed
    4. Flavin WP, Bousset L, Green ZC, Chu Y, Skarpathiotis S, Chaney MJ, Kordower JH, Melki R, Campbell EM. Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins. Acta Neuropathol. 2017 May 19. PMID: 28527044.
      View in: PubMed
    5. Collier TJ, Kanaan NM, Kordower JH. Aging and Parkinson's disease: Different sides of the same coin? Mov Disord. 2017 Jul; 32(7):983-990. PMID: 28520211.
      View in: PubMed
    6. Marmion DJ, Kordower JH. a-Synuclein nonhuman primate models of Parkinson's disease. J Neural Transm (Vienna). 2017 Apr 22. PMID: 28434076.
      View in: PubMed
    7. Kordower JH. What would Dr. James Parkinson think today? parcelling out the circuitry of levodopa-induced dyskinesias. Mov Disord. 2017 Apr; 32(4):483-484. PMID: 28425143.
      View in: PubMed
    8. Olanow CW, Kordower JH. Targeting a-Synuclein as a therapy for Parkinson's disease: The battle begins. Mov Disord. 2017 Feb; 32(2):203-207. PMID: 28218461.
      View in: PubMed
    9. Kordower JH, Goetz CG, Chu Y, Halliday GM, Nicholson DA, Musial TF, Marmion DJ, Stoessl AJ, Sossi V, Freeman TB, Olanow CW. Robust graft survival and normalized dopaminergic innervation do not obligate recovery in a Parkinson disease patient. Ann Neurol. 2017 Jan; 81(1):46-57. PMID: 27900791.
      View in: PubMed
    10. Lee JM, Derkinderen P, Kordower JH, Freeman R, Munoz DG, Kremer T, Zago W, Hutten SJ, Adler CH, Serrano GE, Beach TG. The Search for a Peripheral Biopsy Indicator of a-Synuclein Pathology for Parkinson Disease. J Neuropathol Exp Neurol. 2017 Jan 01; 76(1):2-15. PMID: 28069931.
      View in: PubMed
    11. Engen PA, Dodiya HB, Naqib A, Forsyth CB, Green SJ, Voigt RM, Kordower JH, Mutlu EA, Shannon KM, Keshavarzian A. The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy. J Parkinsons Dis. 2017; 7(2):331-346. PMID: 28234259.
      View in: PubMed
    12. Ghosh A, Tyson T, George S, Hildebrandt EN, Steiner JA, Madaj Z, Schulz E, Machiela E, McDonald WG, Escobar Galvis ML, Kordower JH, Van Raamsdonk JM, Colca JR, Brundin P. Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease. Sci Transl Med. 2016 Dec 07; 8(368):368ra174. PMID: 27928028.
      View in: PubMed
    13. Dodiya HB, Bjorklund T, Stansell Iii J, Mandel RJ, Kirik D, Kordower JH. Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates. Mol Ther. 2010 Mar; 18(3):579-587. PMID: 28182881.
      View in: PubMed
    14. Kordower JH, Brundin P. Mechanisms for cell-to-cell propagation no longer lag behind. Mov Disord. 2016 Dec; 31(12):1798-1799. PMID: 27873365.
      View in: PubMed
    15. Beach TG, Corbillé AG, Letournel F, Kordower JH, Kremer T, Munoz DG, Intorcia A, Hentz J, Adler CH, Sue LI, Walker J, Serrano G, Derkinderen P. Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson's Disease and Control Subjects. J Parkinsons Dis. 2016 Oct 19; 6(4):761-770. PMID: 27589538.
      View in: PubMed
    16. Kurowska Z, Kordower JH, Stoessl AJ, Burke RE, Brundin P, Yue Z, Brady ST, Milbrandt J, Trapp BD, Sherer TB, Medicetty S. Is Axonal Degeneration a Key Early Event in Parkinson's Disease? J Parkinsons Dis. 2016 Oct 19; 6(4):703-707. PMID: 27497486.
      View in: PubMed
    17. Kordower JH, Vinuela A, Chu Y, Isacson O, Redmond DE. Parkinsonian monkeys with prior levodopa-induced dyskinesias followed by fetal dopamine precursor grafts do not display graft-induced dyskinesias. J Comp Neurol. 2017 Feb 15; 525(3):498-512. PMID: 27418401.
      View in: PubMed
    18. Brundin P, Ma J, Kordower JH. How strong is the evidence that Parkinson's disease is a prion disorder? Curr Opin Neurol. 2016 Aug; 29(4):459-66. PMID: 27257944.
      View in: PubMed
    19. Kordower JH, Olanow CW. Fetal grafts for Parkinson's disease: Decades in the making. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):6332-4. PMID: 27247420; PMCID: PMC4988600 [Available on 12/07/16].
    20. Meriggioli MN, Kordower JH. TDP-43 Proteinopathy: Aggregation and Propagation in the Pathogenesis of Amyotrophic Lateral Sclerosis. Mov Disord. 2016 Aug; 31(8):1139. PMID: 27214572.
      View in: PubMed
    21. Chandra G, Rangasamy SB, Roy A, Kordower JH, Pahan K. Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease. J Biol Chem. 2016 07 15; 291(29):15267-81. PMID: 27226559; PMCID: PMC4946939 [Available on 07/15/17].
    22. Corbillé AG, Letournel F, Kordower JH, Lee J, Shanes E, Neunlist M, Munoz DG, Derkinderen P, Beach TG. Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies. Acta Neuropathol Commun. 2016 Apr 04; 4:35. PMID: 27044604; PMCID: PMC4820972.
    23. Stefanova N, Kordower JH, Wenning GK. Preface. Mov Disord. 2016 Feb; 31(2):151. PMID: 26853078.
      View in: PubMed
    24. Chu Y, Morfini GA, Kordower JH. Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease. J Parkinsons Dis. 2016; 6(1):77-97. PMID: 27003787.
      View in: PubMed
    25. Kordower JH. AAV2-Neurturin for Parkinson's Disease: What Lessons Have We Learned? Methods Mol Biol. 2016; 1382:485-90. PMID: 26611606.
      View in: PubMed
    26. Fung VS, Kordower JH. Parkinson's disease and prion disease: Straining the comparison. Mov Disord. 2015 Nov; 30(13):1727. PMID: 26769458.
      View in: PubMed
    27. Olanow CW, Bartus RT, Volpicelli-Daley LA, Kordower JH. Trophic factors for Parkinson's disease: To live or let die. Mov Disord. 2015 Nov; 30(13):1715-24. PMID: 26769457.
      View in: PubMed
    28. Keiser MS, Kordower JH, Gonzalez-Alegre P, Davidson BL. Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy. Brain. 2015 Dec; 138(Pt 12):3555-66. PMID: 26490326; PMCID: PMC4840549 [Available on 12/01/16].
    29. Dehay B, Vila M, Bezard E, Brundin P, Kordower JH. Alpha-synuclein propagation: New insights from animal models. Mov Disord. 2016 Feb; 31(2):161-8. PMID: 26347034.
      View in: PubMed
    30. Su X, Chu Y, Kordower JH, Li B, Cao H, Huang L, Nishida M, Song L, Wang D, Federoff HJ. PGC-1a Promoter Methylation in Parkinson's Disease. PLoS One. 2015; 10(8):e0134087. PMID: 26317511; PMCID: PMC4552803.
    31. Corbett GT, Kordower JH. The native form of a-Synuclein: Monomer, tetramer, or a combination in equilibrium. Mov Disord. 2015 Dec; 30(14):1870. PMID: 26230906.
      View in: PubMed
    32. Gatto RG, Chu Y, Ye AQ, Price SD, Tavassoli E, Buenaventura A, Brady ST, Magin RL, Kordower JH, Morfini GA. Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease. Hum Mol Genet. 2015 Sep 15; 24(18):5285-98. PMID: 26123489; PMCID: PMC4550824.
    33. Warren Olanow C, Bartus RT, Baumann TL, Factor S, Boulis N, Stacy M, Turner DA, Marks W, Larson P, Starr PA, Jankovic J, Simpson R, Watts R, Guthrie B, Poston K, Henderson JM, Stern M, Baltuch G, Goetz CG, Herzog C, Kordower JH, Alterman R, Lozano AM, Lang AE. Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial. Ann Neurol. 2015 Aug; 78(2):248-57. PMID: 26061140.
      View in: PubMed
    34. Chu Y, Kordower JH. The prion hypothesis of Parkinson's disease. Curr Neurol Neurosci Rep. 2015 May; 15(5):28. PMID: 25868519.
      View in: PubMed
    35. Bartus RT, Kordower JH, Johnson EM, Brown L, Kruegel BR, Chu Y, Baumann TL, Lang AE, Olanow CW, Herzog CD. Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with a-synucleinopathies. Neurobiol Dis. 2015 Jun; 78:162-71. PMID: 25841760.
      View in: PubMed
    36. Roy A, Mondal S, Kordower JH, Pahan K. Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey. Neuroscience. 2015 Aug 27; 302:36-46. PMID: 25783477; PMCID: PMC4527882.
    37. Kordower JH. Gene therapy for Parkinson's disease: still a hot topic? Neuropsychopharmacology. 2015 Jan; 40(1):255-6. PMID: 25482182; PMCID: PMC4262915.
    38. Wakeman DR, Kordower JH. Special issue on stem cells. J Comp Neurol. 2014 Aug 15; 522(12):2689-90. PMID: 24942075.
      View in: PubMed
    39. Kordower JH, Halliday G. Misfolded proteins in Huntington disease fetal grafts: further evidence of cell-to-cell transfer? Ann Neurol. 2014 Jul; 76(1):20-1. PMID: 24961209.
      View in: PubMed
    40. Olanow CW, Wakeman DR, Kordower JH. Peripheral alpha-synuclein and Parkinson's disease. Mov Disord. 2014 Jul; 29(8):963-6. PMID: 25043799.
      View in: PubMed
    41. Kordower JH. The prion hypothesis of Parkinson's disease: this hot topic just got hotter. Mov Disord. 2014 Jul; 29(8):988. PMID: 24867814.
      View in: PubMed
    42. Chu Y, Goldman JG, Kelly L, He Y, Waliczek T, Kordower JH. Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease. Neurobiol Dis. 2014 Sep; 69:1-14. PMID: 24825319.
      View in: PubMed
    43. Mattis VB, Wakeman DR, Tom C, Dodiya HB, Yeung SY, Tran AH, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, Thompson LM, Kordower JH, Svendsen CN. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Exp Neurol. 2014 Apr; 254:90-8. PMID: 24440640; PMCID: PMC3954854.
    44. Rafii MS, Baumann TL, Bakay RA, Ostrove JM, Siffert J, Fleisher AS, Herzog CD, Barba D, Pay M, Salmon DP, Chu Y, Kordower JH, Bishop K, Keator D, Potkin S, Bartus RT. A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease. Alzheimers Dement. 2014 Sep; 10(5):571-81. PMID: 24411134.
      View in: PubMed
    45. Kelly LP, Carvey PM, Keshavarzian A, Shannon KM, Shaikh M, Bakay RA, Kordower JH. Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease. Mov Disord. 2014 Jul; 29(8):999-1009. PMID: 24898698; PMCID: PMC4050039.
    46. Kordower JH. In memorium: Roy A.E. Bakay, MD. Mov Disord. 2013 Nov; 28(13):1809-10. PMID: 24150793.
      View in: PubMed
    47. Roy A, Jana M, Corbett GT, Ramaswamy S, Kordower JH, Gonzalez FJ, Pahan K. Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor a. Cell Rep. 2013 Aug 29; 4(4):724-37. PMID: 23972989; PMCID: PMC3804033.
    48. Kordower JH, Olanow CW, Dodiya HB, Chu Y, Beach TG, Adler CH, Halliday GM, Bartus RT. Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain. 2013 Aug; 136(Pt 8):2419-31. PMID: 23884810; PMCID: PMC3722357.
    49. Tavares AA, Batis J, Barret O, Alagille D, Vala C, Kudej G, Koren A, Cosgrove KP, Nice K, Kordower JH, Seibyl J, Tamagnan GD. In vivo evaluation of [(123)I]MNI-420: a novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain. Nucl Med Biol. 2013 Apr; 40(3):403-9. PMID: 23332393.
      View in: PubMed
    50. Bhatt MA, Messer A, Kordower JH. Can intrabodies serve as neuroprotective therapies for Parkinson's disease? Beginning thoughts. J Parkinsons Dis. 2013; 3(4):581-91. PMID: 24270241.
      View in: PubMed
    51. Cederfjäll E, Nilsson N, Sahin G, Chu Y, Nikitidou E, Björklund T, Kordower JH, Kirik D. Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease. Sci Rep. 2013; 3:2157. PMID: 23831692; PMCID: PMC3703607.
    52. Bjorklund A, Kordower JH. Cell therapy for Parkinson's disease: what next? Mov Disord. 2013 Jan; 28(1):110-5. PMID: 23390097.
      View in: PubMed
    53. Kordower JH, Bjorklund A. Trophic factor gene therapy for Parkinson's disease. Mov Disord. 2013 Jan; 28(1):96-109. PMID: 23390096.
      View in: PubMed
    54. Tavares AA, Barret O, Batis J, Alagille D, Koren A, Papin C, Kudej G, Nice K, Kordower JH, Cosgrove KP, Kloczynski T, Brenner E, Seibyl J, Tamagnan G. Kinetic modeling and occupancy measures of the norepinephrine transporters in baboons using single photon emission computed tomography with (123)I-INER. Synapse. 2013 Jan; 67(1):30-41. PMID: 23042643.
      View in: PubMed
    55. Wayman WN, Dodiya HB, Persons AL, Kashanchi F, Kordower JH, Hu XT, Napier TC. Enduring cortical alterations after a single in-vivo treatment of HIV-1 Tat. Neuroreport. 2012 Oct 03; 23(14):825-9. PMID: 22828409; PMCID: PMC3555038.
    56. Kordower JH, Kirik D. Introduction: gene therapy has gone from a pipe dream to clinical reality. Neurobiol Dis. 2012 Nov; 48(2):151-2. PMID: 22841531.
      View in: PubMed
    57. Chu Y, Morfini GA, Langhamer LB, He Y, Brady ST, Kordower JH. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain. 2012 Jul; 135(Pt 7):2058-73. PMID: 22719003; PMCID: PMC4571141.
    58. Mondal S, Roy A, Jana A, Ghosh S, Kordower JH, Pahan K. Testing NF-?B-based therapy in hemiparkinsonian monkeys. J Neuroimmune Pharmacol. 2012 Sep; 7(3):544-56. PMID: 22661311; PMCID: PMC3419771.
    59. Shannon KM, Keshavarzian A, Dodiya HB, Jakate S, Kordower JH. Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases. Mov Disord. 2012 May; 27(6):716-9. PMID: 22550057.
      View in: PubMed
    60. Brundin P, Kordower JH. Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy. Prog Brain Res. 2012; 200:221-41. PMID: 23195421.
      View in: PubMed
    61. Ramaswamy S, Kordower JH. Gene therapy for Huntington's disease. Neurobiol Dis. 2012 Nov; 48(2):243-54. PMID: 22222669.
      View in: PubMed
    62. Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, Jaglin JA, Estes JD, Dodiya HB, Keshavarzian A. Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease. PLoS One. 2011; 6(12):e28032. PMID: 22145021; PMCID: PMC3228722.
    63. Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V, Studer L. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature. 2011 Nov 06; 480(7378):547-51. PMID: 22056989; PMCID: PMC3245796.
    64. Herzog CD, Bishop KM, Brown L, Wilson A, Kordower JH, Bartus RT. Gene transfer provides a practical means for safe, long-term, targeted delivery of biologically active neurotrophic factor proteins for neurodegenerative diseases. Drug Deliv Transl Res. 2011 Oct; 1(5):361-82. PMID: 25788422.
      View in: PubMed
    65. Thompson VB, Koprich JB, Chen EY, Kordower JH, Terpstra BT, Lipton JW. Prenatal exposure to MDMA alters noradrenergic neurodevelopment in the rat. Neurotoxicol Teratol. 2012 Jan-Feb; 34(1):206-13. PMID: 21978916; PMCID: PMC3268906.
    66. Mickiewicz AL, Kordower JH. GDNF family ligands: a potential future for Parkinson's disease therapy. CNS Neurol Disord Drug Targets. 2011 Sep 01; 10(6):703-11. PMID: 21838676.
      View in: PubMed
    67. Shannon KM, Keshavarzian A, Mutlu E, Dodiya HB, Daian D, Jaglin JA, Kordower JH. Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease. Mov Disord. 2012 May; 27(6):709-15. PMID: 21766334.
      View in: PubMed
    68. Bartus RT, Brown L, Wilson A, Kruegel B, Siffert J, Johnson EM, Kordower JH, Herzog CD. Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease. Neurobiol Dis. 2011 Oct; 44(1):38-52. PMID: 21704161.
      View in: PubMed
    69. Collier TJ, Kanaan NM, Kordower JH. Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates. Nat Rev Neurosci. 2011 06; 12(6):359-66. PMID: 21587290; PMCID: PMC3387674.
    70. Kordower JH, Dodiya HB, Kordower AM, Terpstra B, Paumier K, Madhavan L, Sortwell C, Steece-Collier K, Collier TJ. Transfer of host-derived a synuclein to grafted dopaminergic neurons in rat. Neurobiol Dis. 2011 Sep; 43(3):552-7. PMID: 21600984; PMCID: PMC3430516.
    71. Wakeman DR, Dodiya HB, Kordower JH. Cell transplantation and gene therapy in Parkinson's disease. Mt Sinai J Med. 2011 Jan-Feb; 78(1):126-58. PMID: 21259269.
      View in: PubMed
    72. Bartus RT, Herzog CD, Chu Y, Wilson A, Brown L, Siffert J, Johnson EM, Olanow CW, Mufson EJ, Kordower JH. Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains. Mov Disord. 2011 Jan; 26(1):27-36. PMID: 21322017.
      View in: PubMed
    73. Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 2010 Dec; 9(12):1164-72. PMID: 20970382.
      View in: PubMed
    74. Chu Y, Mickiewicz AL, Kordower JH. a-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease. Neurobiol Dis. 2011 Jan; 41(1):71-82. PMID: 20816781.
      View in: PubMed
    75. Cai Y, Xiong K, Zhang XM, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Chu Y, Kordower JH, Yan XX. ß-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and ß-amyloid accumulation. Eur J Neurosci. 2010 Oct; 32(7):1223-38. PMID: 20726888; PMCID: PMC2970759.
    76. Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G. Missing pieces in the Parkinson's disease puzzle. Nat Med. 2010 Jun; 16(6):653-61. PMID: 20495568.
      View in: PubMed
    77. Kordower JH, Chen EY, Morrison JH. Long-term gonadal hormone treatment and endogenous neurogenesis in the dentate gyrus of the adult female monkey. Exp Neurol. 2010 Jul; 224(1):252-7. PMID: 20362573; PMCID: PMC2885495.
    78. Han I, You Y, Kordower JH, Brady ST, Morfini GA. Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features. J Neurochem. 2010 Jun; 113(5):1073-91. PMID: 20236390; PMCID: PMC2890032.
    79. Bjorklund T, Kordower JH. Gene therapy for Parkinson's disease. Mov Disord. 2010; 25 Suppl 1:S161-73. PMID: 20187249.
      View in: PubMed
    80. Rangasamy SB, Soderstrom K, Bakay RA, Kordower JH. Neurotrophic factor therapy for Parkinson's disease. Prog Brain Res. 2010; 184:237-64. PMID: 20887879.
      View in: PubMed
    81. Chu Y, Kordower JH. Lewy body pathology in fetal grafts. Ann N Y Acad Sci. 2010 Jan; 1184:55-67. PMID: 20146690.
      View in: PubMed
    82. Ramaswamy S, Kordower JH. Are growth factors the answer? Parkinsonism Relat Disord. 2009 Dec; 15 Suppl 3:S176-80. PMID: 20082985.
      View in: PubMed
    83. Olanow CW, Kordower JH, Lang AE, Obeso JA. Dopaminergic transplantation for Parkinson's disease: current status and future prospects. Ann Neurol. 2009 Nov; 66(5):591-6. PMID: 19938101.
      View in: PubMed
    84. Zhang XM, Cai Y, Chu Y, Chen EY, Feng JC, Luo XG, Xiong K, Struble RG, Clough RW, Patrylo PR, Kordower JH, Yan XX. Doublecortin-expressing cells persist in the associative cerebral cortex and amygdala in aged nonhuman primates. Front Neuroanat. 2009; 3:17. PMID: 19862344; PMCID: PMC2766270.
    85. Olanow CW, Kordower JH. Modeling Parkinson's disease. Ann Neurol. 2009 Oct; 66(4):432-6. PMID: 19847894.
      View in: PubMed
    86. Mak SK, McCormack AL, Langston JW, Kordower JH, Di Monte DA. Decreased alpha-synuclein expression in the aging mouse substantia nigra. Exp Neurol. 2009 Dec; 220(2):359-65. PMID: 19800328.
      View in: PubMed
    87. Kordower JH, Brundin P. Propagation of host disease to grafted neurons: accumulating evidence. Exp Neurol. 2009 Dec; 220(2):224-5. PMID: 19786018.
      View in: PubMed
    88. Dodiya HB, Bjorklund T, Stansell J, Mandel RJ, Kirik D, Kordower JH. Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates. Mol Ther. 2010 Mar; 18(3):579-87. PMID: 19773746; PMCID: PMC2839447.
    89. Kordower JH. Animal rights terrorists: what every neuroscientist should know. J Neurosci. 2009 Sep 16; 29(37):11419-20. PMID: 19759289.
      View in: PubMed
    90. Emborg ME, Moirano J, Raschke J, Bondarenko V, Zufferey R, Peng S, Ebert AD, Joers V, Roitberg B, Holden JE, Koprich J, Lipton J, Kordower JH, Aebischer P. Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF. Neurobiol Dis. 2009 Nov; 36(2):303-11. PMID: 19660547; PMCID: PMC2989601.
    91. Cicchetti F, Saporta S, Hauser RA, Parent M, Saint-Pierre M, Sanberg PR, Li XJ, Parker JR, Chu Y, Mufson EJ, Kordower JH, Freeman TB. Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12483-8. PMID: 19620721.
      View in: PubMed
    92. Emerich DF, Mooney DJ, Storrie H, Babu RS, Kordower JH. Injectable hydrogels providing sustained delivery of vascular endothelial growth factor are neuroprotective in a rat model of Huntington's disease. Neurotox Res. 2010 Jan; 17(1):66-74. PMID: 19588214.
      View in: PubMed
    93. Sladek JR, Sanberg P, Kordower JH. Celebrating neural repair. J Comp Neurol. 2009 Jul 01; 515(1):1-3. PMID: 19399900.
      View in: PubMed
    94. Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH. Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol Dis. 2009 Sep; 35(3):385-98. PMID: 19505575.
      View in: PubMed
    95. Herzog CD, Brown L, Gammon D, Kruegel B, Lin R, Wilson A, Bolton A, Printz M, Gasmi M, Bishop KM, Kordower JH, Bartus RT. Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease. Neurosurgery. 2009 Apr; 64(4):602-12; discussion 612-3. PMID: 19349823.
      View in: PubMed
    96. Merrill DA, Masliah E, Roberts JA, McKay H, Kordower JH, Mufson EJ, Tuszynski MH. Association of early experience with neurodegeneration in aged primates. Neurobiol Aging. 2011 Jan; 32(1):151-6. PMID: 19321231; PMCID: PMC4210191.
    97. Kordower JH, Brundin P. Lewy body pathology in long-term fetal nigral transplants: is Parkinson's disease transmitted from one neural system to another? Neuropsychopharmacology. 2009 Jan; 34(1):254. PMID: 19079079.
      View in: PubMed
    98. Ramaswamy S, Soderstrom KE, Kordower JH. Trophic factors therapy in Parkinson's disease. Prog Brain Res. 2009; 175:201-16. PMID: 19660658; PMCID: PMC3430519.
    99. Ramaswamy S, McBride JL, Han I, Berry-Kravis EM, Zhou L, Herzog CD, Gasmi M, Bartus RT, Kordower JH. Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease. Neurobiol Dis. 2009 Apr; 34(1):40-50. PMID: 19150499.
      View in: PubMed
    100. Cai Y, Xiong K, Chu Y, Luo DW, Luo XG, Yuan XY, Struble RG, Clough RW, Spencer DD, Williamson A, Kordower JH, Patrylo PR, Yan XX. Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups. Exp Neurol. 2009 Apr; 216(2):342-56. PMID: 19166833; PMCID: PMC2902881.
    101. Kordower JH, Chu Y, Hauser RA, Olanow CW, Freeman TB. Transplanted dopaminergic neurons develop PD pathologic changes: a second case report. Mov Disord. 2008 Dec 15; 23(16):2303-6. PMID: 19006193.
      View in: PubMed
    102. Isacson O, Kordower JH. Future of cell and gene therapies for Parkinson's disease. Ann Neurol. 2008 Dec; 64 Suppl 2:S122-38. PMID: 19127583; PMCID: PMC3982797.
    103. Herzog CD, Dass B, Gasmi M, Bakay R, Stansell JE, Tuszynski M, Bankiewicz K, Chen EY, Chu Y, Bishop K, Kordower JH, Bartus RT. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Mol Ther. 2008 Oct; 16(10):1737-44. PMID: 18728639.
      View in: PubMed
    104. Kanaan NM, Kordower JH, Collier TJ. Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. Neurobiol Aging. 2010 Jun; 31(6):937-52. PMID: 18715678; PMCID: PMC2872507.
    105. Kanaan NM, Kordower JH, Collier TJ. Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys. Glia. 2008 Aug 15; 56(11):1199-214. PMID: 18484101; PMCID: PMC3388430.
    106. Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med. 2008 May; 14(5):504-6. PMID: 18391962.
      View in: PubMed
    107. Pilitsis JG, Chu Y, Kordower J, Bergen DC, Cochran EJ, Bakay RA. Postmortem study of deep brain stimulation of the anterior thalamus: case report. Neurosurgery. 2008 Feb; 62(2):E530-2; discussion E532. PMID: 18382294.
      View in: PubMed
    108. Kordower JH. Introduction to the special ASNTR issue. Cell Transplant. 2008; 17(4):361-2. PMID: 18522238.
      View in: PubMed
    109. Ghosh A, Roy A, Liu X, Kordower JH, Mufson EJ, Hartley DM, Ghosh S, Mosley RL, Gendelman HE, Pahan K. Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18754-9. PMID: 18000063; PMCID: PMC2141849.
    110. Sani S, Jobe K, Smith A, Kordower JH, Bakay RA. Deep brain stimulation for treatment of obesity in rats. J Neurosurg. 2007 Oct; 107(4):809-13. PMID: 17937228.
      View in: PubMed
    111. Kordower JH, Olanow CW. Regulatable promoters and gene therapy for Parkinson's disease: is the only thing to fear, fear itself? Exp Neurol. 2008 Jan; 209(1):34-40. PMID: 17888424; PMCID: PMC3913266.
    112. Kompoliti K, Chu Y, Shannon KM, Kordower JH. Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient. Mov Disord. 2007 Aug 15; 22(11):1630-3. PMID: 17534949.
      View in: PubMed
    113. Herzog CD, Dass B, Holden JE, Stansell J, Gasmi M, Tuszynski MH, Bartus RT, Kordower JH. Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys. Mov Disord. 2007 Jun 15; 22(8):1124-32. PMID: 17443702.
      View in: PubMed
    114. Kanaan NM, Kordower JH, Collier TJ. Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability. J Comp Neurol. 2007 Jun 10; 502(5):683-700. PMID: 17436290.
      View in: PubMed
    115. Gasmi M, Brandon EP, Herzog CD, Wilson A, Bishop KM, Hofer EK, Cunningham JJ, Printz MA, Kordower JH, Bartus RT. AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease. Neurobiol Dis. 2007 Jul; 27(1):67-76. PMID: 17532642.
      View in: PubMed
    116. Marchionini DM, Lehrmann E, Chu Y, He B, Sortwell CE, Becker KG, Freed WJ, Kordower JH, Collier TJ. Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease. Brain Res. 2007 May 25; 1147:77-88. PMID: 17368428.
      View in: PubMed
    117. Ramaswamy S, McBride JL, Herzog CD, Brandon E, Gasmi M, Bartus RT, Kordower JH. Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease. Neurobiol Dis. 2007 May; 26(2):375-84. PMID: 17336076.
      View in: PubMed
    118. Ramaswamy S, Shannon KM, Kordower JH. Huntington's disease: pathological mechanisms and therapeutic strategies. Cell Transplant. 2007; 16(3):301-12. PMID: 17503740.
      View in: PubMed
    119. Bartus RT, Herzog CD, Bishop K, Ostrove JM, Tuszynski M, Kordower JH, Gasmi M. Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point. Parkinsonism Relat Disord. 2007; 13 Suppl 3:S469-77. PMID: 18267286.
      View in: PubMed
    120. Ramaswamy S, McBride JL, Kordower JH. Animal models of Huntington's disease. ILAR J. 2007; 48(4):356-73. PMID: 17712222.
      View in: PubMed
    121. Kordower JH, Herzog CD, Dass B, Bakay RA, Stansell J, Gasmi M, Bartus RT. Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Ann Neurol. 2006 Dec; 60(6):706-15. PMID: 17192932.
      View in: PubMed
    122. Chu Y, Kordower JH. Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease? Neurobiol Dis. 2007 Jan; 25(1):134-49. PMID: 17055279.
      View in: PubMed
    123. Kordower JH, Kanaan NM, Chu Y, Suresh Babu R, Stansell J, Terpstra BT, Sortwell CE, Steece-Collier K, Collier TJ. Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys. Ann Neurol. 2006 Aug; 60(2):264-8. PMID: 16862579.
      View in: PubMed
    124. McBride JL, Ramaswamy S, Gasmi M, Bartus RT, Herzog CD, Brandon EP, Zhou L, Pitzer MR, Berry-Kravis EM, Kordower JH. Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9345-50. PMID: 16751280; PMCID: PMC1482612.
    125. Dass B, Olanow CW, Kordower JH. Gene transfer of trophic factors and stem cell grafting as treatments for Parkinson's disease. Neurology. 2006 May 23; 66(10 Suppl 4):S89-103. PMID: 16717256.
      View in: PubMed
    126. Chu Y, Le W, Kompoliti K, Jankovic J, Mufson EJ, Kordower JH. Nurr1 in Parkinson's disease and related disorders. J Comp Neurol. 2006 Jan 20; 494(3):495-514. PMID: 16320253; PMCID: PMC2564615.
    127. Soderstrom K, O'Malley J, Steece-Collier K, Kordower JH. Neural repair strategies for Parkinson's disease: insights from primate models. Cell Transplant. 2006; 15(3):251-65. PMID: 16719060.
      View in: PubMed
    128. Schneider JA, Li JL, Li Y, Wilson RS, Kordower JH, Bennett DA. Substantia nigra tangles are related to gait impairment in older persons. Ann Neurol. 2006 Jan; 59(1):166-73. PMID: 16374822.
      View in: PubMed
    129. Dass B, Kladis T, Chu Y, Kordower JH. RET expression does not change with age in the substantia nigra pars compacta of rhesus monkeys. Neurobiol Aging. 2006 Jun; 27(6):857-61. PMID: 15950322.
      View in: PubMed
    130. Collier TJ, Dung Ling Z, Carvey PM, Fletcher-Turner A, Yurek DM, Sladek JR, Kordower JH. Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism. Exp Neurol. 2005 Feb; 191 Suppl 1:S60-7. PMID: 15629762.
      View in: PubMed
    131. Counts SE, Chen EY, Ginsberg SD, Kordower JH, Mufson EJ. RNA amplification of bromodeoxyuridine labeled newborn neurons in the monkey hippocampus. J Neurosci Methods. 2005 Jun 15; 144(2):197-201. PMID: 15910978.
      View in: PubMed
    132. McBride JL, Behrstock SP, Chen EY, Jakel RJ, Siegel I, Svendsen CN, Kordower JH. Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. J Comp Neurol. 2004 Jul 19; 475(2):211-9. PMID: 15211462.
      View in: PubMed
    133. Kompoliti K, Chu Y, Polish A, Roberts J, McKay H, Mufson EJ, Leurgans S, Morrison JH, Kordower JH. Effects of estrogen replacement therapy on cholinergic basal forebrain neurons and cortical cholinergic innervation in young and aged ovariectomized rhesus monkeys. J Comp Neurol. 2004 Apr 26; 472(2):193-207. PMID: 15048687.
      View in: PubMed
    134. Collier TJ, Steece-Collier K, Kordower JH. Primate models of Parkinson's disease. Exp Neurol. 2003 Oct; 183(2):258-62. PMID: 14552866.
      View in: PubMed
    135. Koprich JB, Chen EY, Kanaan NM, Campbell NG, Kordower JH, Lipton JW. Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) alters exploratory behavior, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase fiber density of juvenile rats. Neurotoxicol Teratol. 2003 Sep-Oct; 25(5):509-17. PMID: 12972064.
      View in: PubMed
    136. Kus L, Borys E, Ping Chu Y, Ferguson SM, Blakely RD, Emborg ME, Kordower JH, Levey AI, Mufson EJ. Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system. J Comp Neurol. 2003 Aug 25; 463(3):341-57. PMID: 12820166.
      View in: PubMed
    137. Hanbury R, Ling ZD, Wuu J, Kordower JH. GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults. J Comp Neurol. 2003 Jun 30; 461(3):307-16. PMID: 12746870.
      View in: PubMed
    138. McBride JL, During MJ, Wuu J, Chen EY, Leurgans SE, Kordower JH. Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF. Exp Neurol. 2003 Jun; 181(2):213-23. PMID: 12781994.
      View in: PubMed
    139. Hanbury R, Chen EY, Wuu J, Kordower JH. Knockout of p75NTR does not alter the viability of striatal neurons following a metabolic or excitotoxic injury. J Mol Neurosci. 2003 Apr; 20(2):93-102. PMID: 12794303.
      View in: PubMed
    140. Kordower JH. In vivo gene delivery of glial cell line--derived neurotrophic factor for Parkinson's disease. Ann Neurol. 2003; 53 Suppl 3:S120-32; discussion S132-4. PMID: 12666104.
      View in: PubMed
    141. Roitberg B, Khan N, Tuccar E, Kompoliti K, Chu Y, Alperin N, Kordower JH, Emborg ME. Chronic ischemic stroke model in cynomolgus monkeys: behavioral, neuroimaging and anatomical study. Neurol Res. 2003 Jan; 25(1):68-78. PMID: 12564129.
      View in: PubMed
    142. Steece-Collier K, Maries E, Kordower JH. Etiology of Parkinson's disease: Genetics and environment revisited. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):13972-4. PMID: 12391311; PMCID: PMC137821.
    143. Chu Y, Kompoliti K, Cochran EJ, Mufson EJ, Kordower JH. Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra. J Comp Neurol. 2002 Aug 26; 450(3):203-14. PMID: 12209851.
      View in: PubMed
    144. Palfi S, Leventhal L, Chu Y, Ma SY, Emborg M, Bakay R, Déglon N, Hantraye P, Aebischer P, Kordower JH. Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. J Neurosci. 2002 Jun 15; 22(12):4942-54. PMID: 12077191.
      View in: PubMed
    145. Hanbury R, Charles V, Chen EY, Leventhal L, Rosenstein JM, Mufson EJ, Kordower JH. Excitotoxic and metabolic damage to the rodent striatum: role of the P75 neurotrophin receptor and glial progenitors. J Comp Neurol. 2002 Mar 18; 444(4):291-305. PMID: 11891644.
      View in: PubMed
    146. Mufson EJ, Ma SY, Dills J, Cochran EJ, Leurgans S, Wuu J, Bennett DA, Jaffar S, Gilmor ML, Levey AI, Kordower JH. Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease. J Comp Neurol. 2002 Feb 04; 443(2):136-53. PMID: 11793352.
      View in: PubMed
    147. McBride JL, Kordower JH. Neuroprotection for Parkinson's disease using viral vector-mediated delivery of GDNF. Prog Brain Res. 2002; 138:421-32. PMID: 12432782.
      View in: PubMed
    148. Roitberg BZ, Emborg ME, Sramek JG, Palfi S, Kordower JH. Behavioral and morphological comparison of two nonhuman primate models of Huntington's disease. Neurosurgery. 2002 Jan; 50(1):137-45; discussion 145-6. PMID: 11844244.
      View in: PubMed
    Kordower's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Physical Neighbors Expand Description
    _