 Thioredoxin-Disulfide Reductase
"Thioredoxin-Disulfide Reductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the presence of NADP+. It was formerly listed as EC 1.6.4.5
| Descriptor ID |
D013880
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| MeSH Number(s) |
D08.811.682.667.750 D12.776.331.971
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| Concept/Terms |
Thioredoxin-Disulfide Reductase- Thioredoxin-Disulfide Reductase
- Reductase, Thioredoxin-Disulfide
- Thioredoxin Disulfide Reductase
- Thioredoxin Reductase (NADPH)
- Thioredoxin Reductase
- Reductase, Thioredoxin
- NADP-Thioredoxin Reductase
- NADP Thioredoxin Reductase
- Reductase, NADP-Thioredoxin
- NADPH-Thioredoxin Reductase
- NADPH Thioredoxin Reductase
- Reductase, NADPH-Thioredoxin
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Below are MeSH descriptors whose meaning is more general than "Thioredoxin-Disulfide Reductase".
Below are MeSH descriptors whose meaning is more specific than "Thioredoxin-Disulfide Reductase".
This graph shows the total number of publications written about "Thioredoxin-Disulfide Reductase" by people in this website by year, and whether "Thioredoxin-Disulfide Reductase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thioredoxin-Disulfide Reductase" by people in Profiles.
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Fata F, Gencheva R, Cheng Q, Lullo R, Ardini M, Silvestri I, Gabriele F, Ippoliti R, Bulman CA, Sakanari JA, Williams DL, Arnér ESJ, Angelucci F. Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus. Redox Biol. 2022 05; 51:102278.
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Silvestri I, Lyu H, Fata F, Banta PR, Mattei B, Ippoliti R, Bellelli A, Pitari G, Ardini M, Petukhova V, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Ectopic suicide inhibition of thioredoxin glutathione reductase. Free Radic Biol Med. 2020 02 01; 147:200-211.
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Johann L, Belorgey D, Huang HH, Day L, Chessé M, Becker K, Williams DL, Davioud-Charvet E. Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs. FEBS J. 2015 Aug; 282(16):3199-217.
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Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase. Assay Drug Dev Technol. 2008 Aug; 6(4):551-5.
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Alger HM, Sayed AA, Stadecker MJ, Williams DL. Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin. Int J Parasitol. 2002 Sep; 32(10):1285-92.
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Alger HM, Williams DL. The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase. Mol Biochem Parasitol. 2002 Apr 30; 121(1):129-39.
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Williams DL, Asahi H, Botkin DJ, Stadecker MJ. Schistosome infection stimulates host CD4(+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase. Infect Immun. 2001 Feb; 69(2):1134-41.
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