 Factor IXa
"Factor IXa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Activated form of factor IX. This activation can take place via the intrinsic pathway by the action of factor XIa and calcium, or via the extrinsic pathway by the action of factor VIIa, thromboplastin, and calcium. Factor IXa serves to activate factor X to Xa by cleaving the arginyl-leucine peptide bond in factor X.
| Descriptor ID |
D015949
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| MeSH Number(s) |
D08.811.277.656.300.760.310 D08.811.277.656.959.350.310 D12.776.124.125.375.310 D23.119.375.310
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| Concept/Terms |
Factor IXa- Factor IXa
- Coagulation Factor IXa
- Factor IXa, Coagulation
- IXa, Coagulation Factor
- Blood Coagulation Factor IX, Activated
- Factor IX, Activated
- Activated Factor IX
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Below are MeSH descriptors whose meaning is more general than "Factor IXa".
Below are MeSH descriptors whose meaning is more specific than "Factor IXa".
This graph shows the total number of publications written about "Factor IXa" by people in this website by year, and whether "Factor IXa" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 2 | 0 | 2 |
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Below are the most recent publications written about "Factor IXa" by people in Profiles.
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Meng D, Andre P, Bateman TJ, Berger R, Chen YH, Desai K, Dewnani S, Ellsworth K, Feng D, Geissler WM, Guo L, Hruza A, Jian T, Li H, Metzger J, Parker DL, Reichert P, Sherer EC, Smith CJ, Sonatore LM, Tschirret-Guth R, Wu J, Xu J, Zhang T, Campeau LC, Orr R, Poirier M, McCabe-Dunn J, Araki K, Nishimura T, Sakurada I, Hirabayashi T, Wood HB. Development of a novel tricyclic class of potent and selective FIXa inhibitors. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5437-43.
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Parker DL, Walsh S, Li B, Kim E, Sharipour A, Smith C, Chen YH, Berger R, Harper B, Zhang T, Park M, Shu M, Wu J, Xu J, Dewnani S, Sherer EC, Hruza A, Reichert P, Geissler W, Sonatore L, Ellsworth K, Balkovec J, Greenlee W, Wood HB. Rapid development of two factor IXa inhibitors from hit to lead. Bioorg Med Chem Lett. 2015 Jun 01; 25(11):2321-5.
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