 Erythromycin
"Erythromycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
| Descriptor ID |
D004917
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| MeSH Number(s) |
D02.540.505.250
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Erythromycin".
Below are MeSH descriptors whose meaning is more specific than "Erythromycin".
This graph shows the total number of publications written about "Erythromycin" by people in this website by year, and whether "Erythromycin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 1 | 1 | 2 | | 1987 | 3 | 0 | 3 | | 1990 | 1 | 0 | 1 | | 1993 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Erythromycin" by people in Profiles.
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Zhang X, Galinsky RE, Kimura RE, Quinney SK, Jones DR, Hall SD. Inhibition of CYP3A by erythromycin: in vitro-in vivo correlation in rats. Drug Metab Dispos. 2010 Jan; 38(1):61-72.
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Cvetanovic I, Ranade V, Lin C, Somberg J. The differential antibacterial and gastrointestinal effects of erythromycin and its chiral isolates. Am J Ther. 2006 Jan-Feb; 13(1):48-56.
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Brikun IA, Reeves AR, Cernota WH, Luu MB, Weber JM. The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum. J Ind Microbiol Biotechnol. 2004 Aug; 31(7):335-44.
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Segreti J, Meyer P, Kapell K. In vitro activity of macrolides against intracellular Legionella pneumophila. Diagn Microbiol Infect Dis. 1996 Jul; 25(3):123-6.
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Segreti J, Kapell KS. In vitro activity of dirithromycin against Chlamydia trachomatis. Antimicrob Agents Chemother. 1994 Sep; 38(9):2213-4.
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Keshavarzian A, Isaac RM. Erythromycin accelerates gastric emptying of indigestible solids and transpyloric migration of the tip of an enteral feeding tube in fasting and fed states. Am J Gastroenterol. 1993 Feb; 88(2):193-7.
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Berger SA, Keshavarzian A, DeMeo MT, Mobarhan S. Erythromycin in chronic intestinal pseudo-obstruction. J Clin Gastroenterol. 1990 Jun; 12(3):363.
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Benson C, Segreti J, Kessler H, Hines D, Goodman L, Kaplan R, Trenholme G. Comparative in vitro activity of A-56268 (TE-031) against gram-positive and gram-negative bacteria and Chlamydia trachomatis. Eur J Clin Microbiol. 1987 Apr; 6(2):173-8.
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Benson CA, Segreti J, Beaudette FE, Hines DW, Goodman LJ, Kaplan RL, Trenholme GM. In vitro activity of A-56268 (TE-031), a new macrolide, compared with that of erythromycin and clindamycin against selected gram-positive and gram-negative organisms. Antimicrob Agents Chemother. 1987 Feb; 31(2):328-30.
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Segreti J, Kessler HA, Kapell KS, Trenholme GM. In vitro activity of A-56268 (TE-031) and four other antimicrobial agents against Chlamydia trachomatis. Antimicrob Agents Chemother. 1987 Jan; 31(1):100-1.
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