NADH, NADPH Oxidoreductases
"NADH, NADPH Oxidoreductases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.
| Descriptor ID |
D009247
|
| MeSH Number(s) |
D08.811.682.608
|
| Concept/Terms |
NADH, NADPH Oxidoreductases- NADH, NADPH Oxidoreductases
- NADPH Oxidoreductases NADH
- Oxidoreductases NADH, NADPH
- Oxidoreductases, NADH, NADPH
|
Below are MeSH descriptors whose meaning is more general than "NADH, NADPH Oxidoreductases".
Below are MeSH descriptors whose meaning is more specific than "NADH, NADPH Oxidoreductases".
This graph shows the total number of publications written about "NADH, NADPH Oxidoreductases" by people in this website by year, and whether "NADH, NADPH Oxidoreductases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "NADH, NADPH Oxidoreductases" by people in Profiles.
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Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. Nat Commun. 2023 06 22; 14(1):3737.
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Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis. ACS Infect Dis. 2020 03 13; 6(3):393-405.
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Ectopic suicide inhibition of thioredoxin glutathione reductase. Free Radic Biol Med. 2020 02 01; 147:200-211.
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High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis. Infect Dis Poverty. 2015 Aug 31; 4:40.
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Proteomic profiling of nitrosative stress: protein S-oxidation accompanies S-nitrosylation. ACS Chem Biol. 2014 Mar 21; 9(3):821-30.
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Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites. Antioxid Redox Signal. 2013 Sep 01; 19(7):735-45.
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Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni. Biochemistry. 2011 Jul 05; 50(26):5870-82.
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Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med. 2008 Apr; 14(4):407-12.
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Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med. 2007 Jun; 4(6):e206.
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The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase. Mol Biochem Parasitol. 2002 Apr 30; 121(1):129-39.