Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
|
MeSH Number(s) |
E05.393.620.500
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Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
|
Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 3 | 3 |
1995 | 0 | 1 | 1 |
1996 | 2 | 6 | 8 |
1997 | 2 | 9 | 11 |
1998 | 0 | 5 | 5 |
1999 | 0 | 4 | 4 |
2000 | 1 | 3 | 4 |
2001 | 2 | 3 | 5 |
2002 | 2 | 5 | 7 |
2003 | 0 | 8 | 8 |
2004 | 1 | 4 | 5 |
2005 | 1 | 6 | 7 |
2006 | 0 | 5 | 5 |
2007 | 3 | 4 | 7 |
2008 | 1 | 5 | 6 |
2009 | 0 | 7 | 7 |
2010 | 0 | 5 | 5 |
2011 | 0 | 5 | 5 |
2012 | 0 | 5 | 5 |
2013 | 0 | 3 | 3 |
2014 | 0 | 4 | 4 |
2015 | 1 | 1 | 2 |
2016 | 1 | 4 | 5 |
2017 | 0 | 3 | 3 |
2018 | 1 | 0 | 1 |
2020 | 0 | 1 | 1 |
2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Prevalent subtypes and one-year outcomes of an HIV-cohort from an urban Philippine center. Medicine (Baltimore). 2021 Dec 23; 100(51):e28315.
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Diagnostic profile of the AmplideX Fragile X Dx and Carrier Screen Kit for diagnosis and screening of fragile X syndrome and other FMR1-related disorders. Expert Rev Mol Diagn. 2021 03; 21(3):255-267.
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The perplexing problem of persistently PCR-positive personnel. Infect Control Hosp Epidemiol. 2021 02; 42(2):203-204.
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Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA. Mol Neurobiol. 2018 Nov; 55(11):8728-8737.
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Comparison of lesional skin c-KIT mutations with clinical phenotype in patients with mastocytosis. Clin Exp Dermatol. 2018 Jun; 43(4):416-422.
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Microbial Diversity of Genital Ulcers of HSV-2 Seropositive Women. Sci Rep. 2017 11 13; 7(1):15475.
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Effect of cytomegalovirus and Epstein-Barr virus replication on intestinal mucosal gene expression and microbiome composition of HIV-infected and uninfected individuals. AIDS. 2017 09 24; 31(15):2059-2067.
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Procalcitonin as a Marker of Etiology in Adults Hospitalized With Community-Acquired Pneumonia. Clin Infect Dis. 2017 Jul 15; 65(2):183-190.
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A methylation PCR method determines FMR1 activation ratios and differentiates premutation allele mosaicism in carrier siblings. Clin Epigenetics. 2016; 8:130.
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Chlorhexidine and Mupirocin Susceptibility of Methicillin-Resistant Staphylococcus aureus Isolates in the REDUCE-MRSA Trial. J Clin Microbiol. 2016 11; 54(11):2735-2742.