"Dopamine Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
| Descriptor ID |
D018492
|
| MeSH Number(s) |
D27.505.519.625.150.175 D27.505.696.577.150.175
|
| Concept/Terms |
Dopamine Antagonists- Dopamine Antagonists
- Dopaminergic Antagonists
- Dopamine Blockers
- Blockers, Dopamine
- Antagonists, Dopamine Receptor
- Receptor Antagonists, Dopamine
- Antagonists, Dopaminergic
- Dopamine Receptor Antagonists
- Antagonists, Dopamine
|
Below are MeSH descriptors whose meaning is more general than "Dopamine Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Dopamine Antagonists".
This graph shows the total number of publications written about "Dopamine Antagonists" by people in this website by year, and whether "Dopamine Antagonists" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 3 | 3 |
| 2011 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dopamine Antagonists" by people in Profiles.
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Valbenazine in the treatment of tardive dyskinesia. Neurodegener Dis Manag. 2019 04; 9(2):73-81.
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Dopamine Antagonists in ICU Delirium. N Engl J Med. 2018 12 27; 379(26):2569-2570.
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Repeated cocaine exposure decreases dopamine D2-like receptor modulation of Ca(2+) homeostasis in rat nucleus accumbens neurons. Synapse. 2011 Feb; 65(2):168-80.
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Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons. J Neurophysiol. 2005 Mar; 93(3):1406-17.
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Limbic pallidal adaptations following long-term cessation of dopaminergic transmission: lack of upregulation of dopamine receptor function. Exp Neurol. 2004 Apr; 186(2):145-57.
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Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons. J Neurosci. 2004 Mar 24; 24(12):3077-85.
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Alterations in striatal neurotrophic activity induced by dopaminergic drugs. Pharmacol Biochem Behav. 1993 Sep; 46(1):195-204.
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New approaches in the treatment of the dystonias. Klin Wochenschr. 1990 Oct 03; 68(19):935-41.
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MPTP-induced duodenal ulcers in rat. Prevention by reuptake blockers for serotonin and norepinephrine, but not dopamine. Gastroenterology. 1990 Mar; 98(3):554-60.
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Effects of dopamine antagonists and apomorphine on regional energy metabolism in rat CNS. Clin Neuropharmacol. 1987 Jun; 10(3):247-60.