Last Name

Ed Barker

InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
Address1735 W. Harrison St.
Chicago IL 60612
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    My Scopus ID is 7103411264.

    Research Areas:
    Natural killer cells and HIV, innate lymphoid cells in HIV infection.

    My Faculty Profile at Rush University Medical Center:

    My NCBI Bibliography:

    My Scopus:

    PhD, University of Illinois

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tay N, Macare C, Liu Y, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Frieling H, Bleich S, Barker ED, Syvänen AC, Rüegg J, Ekström TJ, Bakalkin G, Schumann G. Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse. Am J Psychiatry. 2019 Feb 01; 176(2):146-155. PMID: 30525907.
      View in: PubMed
    2. Dillon SM, Castleman MJ, Frank DN, Austin GL, Gianella S, Cogswell AC, Landay AL, Barker E, Wilson CC. Brief Report: Inflammatory Colonic Innate Lymphoid Cells Are Increased During Untreated HIV-1 Infection and Associated With Markers of Gut Dysbiosis and Mucosal Immune Activation. J Acquir Immune Defic Syndr. 2017 12 01; 76(4):431-437. PMID: 28825942.
      View in: PubMed
    3. Quinlan EB, Cattrell A, Jia T, Artiges E, Banaschewski T, Barker G, Bokde ALW, Bromberg U, Büchel C, Brühl R, Conrod PJ, Desrivieres S, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Martinot JL, Paillère Martinot ML, Nees F, Papadopoulos-Orfanos D, Paus T, Poustka L, Smolka MN, Vetter NC, Walter H, Whelan R, Glennon JC, Buitelaar JK, Happé F, Loth E, Barker ED, Schumann G. Psychosocial Stress and Brain Function in Adolescent Psychopathology. Am J Psychiatry. 2017 08 01; 174(8):785-794. PMID: 28618856.
      View in: PubMed
    4. Garrido C, Spivak AM, Soriano-Sarabia N, Checkley MA, Barker E, Karn J, Planelles V, Margolis DM. HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function. Front Immunol. 2016; 7:356. PMID: 27708642.
      View in: PubMed
    5. Davis ZB, Sowrirajan B, Cogswell A, Ward JP, Planelles V, Barker E. CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells. AIDS Res Hum Retroviruses. 2017 02; 33(2):93-100. PMID: 27296670.
      View in: PubMed
    6. Barker E, Evans DT. HLA-C Downmodulation by HIV-1 Vpu. Cell Host Microbe. 2016 05 11; 19(5):570-1. PMID: 27173922.
      View in: PubMed
    7. Boudreau JE, Mulrooney TJ, Le Luduec JB, Barker E, Hsu KC. KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV. J Immunol. 2016 Apr 15; 196(8):3398-410. PMID: 26962229; PMCID: PMC4868784 [Available on 04/15/17].
    8. Davis ZB, Cogswell A, Scott H, Mertsching A, Boucau J, Wambua D, Le Gall S, Planelles V, Campbell KS, Barker E. A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells. PLoS Pathog. 2016 Feb; 12(2):e1005421. PMID: 26828202.
      View in: PubMed
    9. Ramirez PW, DePaula-Silva AB, Szaniawski M, Barker E, Bosque A, Planelles V. HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins. Retrovirology. 2015 Jul 28; 12:65. PMID: 26215564; PMCID: PMC4517359.
    10. Cassiday PA, DePaula-Silva AB, Chumley J, Ward J, Barker E, Planelles V. Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx. Virology. 2015 Feb; 476:19-25. PMID: 25499532; PMCID: PMC4323848.
    11. Ramirez PW, Famiglietti M, Sowrirajan B, DePaula-Silva AB, Rodesch C, Barker E, Bosque A, Planelles V. Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4? T cells. Cell Rep. 2014 Jun 26; 7(6):2019-30. PMID: 24910430; PMCID: PMC4080720.
    12. Dillon SM, Lee EJ, Bramante JM, Barker E, Wilson CC. The natural killer cell interferon-gamma response to bacteria is diminished in untreated HIV-1 infection and defects persist despite viral suppression. J Acquir Immune Defic Syndr. 2014 Mar 01; 65(3):259-67. PMID: 24091697; PMCID: PMC3945425.
    13. Sauter D, Unterweger D, Vogl M, Usmani SM, Heigele A, Kluge SF, Hermkes E, Moll M, Barker E, Peeters M, Learn GH, Bibollet-Ruche F, Fritz JV, Fackler OT, Hahn BH, Kirchhoff F. Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein. PLoS Pathog. 2012 Dec; 8(12):e1003093. PMID: 23308067; PMCID: PMC3534379.
    14. Manion M, Rodriguez B, Medvik K, Hardy G, Harding CV, Schooley RT, Pollard R, Asmuth D, Murphy R, Barker E, Brady KE, Landay A, Funderburg N, Sieg SF, Lederman MM. Interferon-alpha administration enhances CD8+ T cell activation in HIV infection. PLoS One. 2012; 7(1):e30306. PMID: 22291932; PMCID: PMC3265460.
    15. Sowrirajan B, Barker E. The natural killer cell cytotoxic function is modulated by HIV-1 accessory proteins. Viruses. 2011 07; 3(7):1091-111. PMID: 21994772; PMCID: PMC3185792.
    16. Davis ZB, Ward JP, Barker E. Preparation and use of HIV-1 infected primary CD4+ T-cells as target cells in natural killer cell cytotoxic assays. J Vis Exp. 2011 Mar 14; (49). PMID: 21445040; PMCID: PMC3197326.
    17. Shah AH, Sowrirajan B, Davis ZB, Ward JP, Campbell EM, Planelles V, Barker E. Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu. Cell Host Microbe. 2010 Nov 18; 8(5):397-409. PMID: 21075351; PMCID: PMC3005698.
    18. Planelles V, Barker E. Roles of Vpr and Vpx in modulating the virus-host cell relationship. Mol Aspects Med. 2010 Oct; 31(5):398-406. PMID: 20558198; PMCID: PMC2967654.
    19. Ward J, Davis Z, DeHart J, Zimmerman E, Bosque A, Brunetta E, Mavilio D, Planelles V, Barker E. HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response. PLoS Pathog. 2009 Oct; 5(10):e1000613. PMID: 19798433; PMCID: PMC2747015.
    20. Fogli M, Mavilio D, Brunetta E, Varchetta S, Ata K, Roby G, Kovacs C, Follmann D, Pende D, Ward J, Barker E, Marcenaro E, Moretta A, Fauci AS. Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals. PLoS Pathog. 2008 Jul 11; 4(7):e1000101. PMID: 18617991; PMCID: PMC2438610.
    21. Ward J, Barker E. Role of natural killer cells in HIV pathogenesis. Curr HIV/AIDS Rep. 2008 Feb; 5(1):44-50. PMID: 18417035.
      View in: PubMed
    22. Barker E, Martinson J, Brooks C, Landay A, Deeks S. Dysfunctional natural killer cells, in vivo, are governed by HIV viremia regardless of whether the infected individual is on antiretroviral therapy. AIDS. 2007 Nov 12; 21(17):2363-5. PMID: 18090295.
      View in: PubMed
    23. Banerjee P, Feuer G, Barker E. Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells. J Virol. 2007 Sep; 81(18):9707-17. PMID: 17609265; PMCID: PMC2045425.
    24. Ward J, Bonaparte M, Sacks J, Guterman J, Fogli M, Mavilio D, Barker E. HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. Blood. 2007 Aug 15; 110(4):1207-14. PMID: 17513617; PMCID: PMC1939902.
    25. Pang J, Cheng M, Haire SE, Barker E, Planelles V, Blanks JC. Efficiency of lentiviral transduction during development in normal and rd mice. Mol Vis. 2006 Jul 11; 12:756-67. PMID: 16862069.
      View in: PubMed
    26. Ward JP, Bonaparte MI, Barker E. HLA-C and HLA-E reduce antibody-dependent natural killer cell-mediated cytotoxicity of HIV-infected primary T cell blasts. AIDS. 2004 Sep 03; 18(13):1769-79. PMID: 15316337.
      View in: PubMed
    27. Bonaparte MI, Barker E. Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility complex class I molecules. Blood. 2004 Oct 01; 104(7):2087-94. PMID: 15117765.
      View in: PubMed
    28. Barker E, Planelles V. Vectors derived from the human immunodeficiency virus, HIV-1. Front Biosci. 2003 May 01; 8:d491-510. PMID: 12700118.
      View in: PubMed
    29. Bonaparte MI, Barker E. Inability of natural killer cells to destroy autologous HIV-infected T lymphocytes. AIDS. 2003 Mar 07; 17(4):487-94. PMID: 12598768.
      View in: PubMed
    30. Wrzesinski S, Séguin R, Liu Y, Domville S, Planelles V, Massa P, Barker E, Antel J, Feuer G. HTLV type 1 Tax transduction in microglial cells and astrocytes by lentiviral vectors. AIDS Res Hum Retroviruses. 2000 Nov 01; 16(16):1771-6. PMID: 11080825.
      View in: PubMed
    31. Barker E, Bossart KN, Fujimura SH, Levy JA. The role of CD80 and CD86 in enhancing CD8(+) cell suppression of HIV replication. Cell Immunol. 1999 Sep 15; 196(2):95-103. PMID: 10527561.
      View in: PubMed
    32. Greco G, Barker E, Levy JA. Differences in HIV replication in CD4+ lymphocytes are not related to beta-chemokine production. AIDS Res Hum Retroviruses. 1998 Nov 01; 14(16):1407-11. PMID: 9824318.
      View in: PubMed
    33. Barker E, Bossart KN, Levy JA. Primary CD8+ cells from HIV-infected individuals can suppress productive infection of macrophages independent of beta-chemokines. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1725-9. PMID: 9465084.
      View in: PubMed
    34. Barker E, Bossart KN, Locher CP, Patterson BK, Levy JA. CD8+ cells from asymptomatic human immunodeficiency virus-infected individuals suppress superinfection of their peripheral blood mononuclear cells. J Gen Virol. 1996 Dec; 77 ( Pt 12):2953-62. PMID: 9000085.
      View in: PubMed
    35. Levy JA, Ramachandran B, Barker E, Guthrie J, Elbeik T. Plasma viral load, CD4+ cell counts, and HIV-1 production by cells. Science. 1996 Feb 02; 271(5249):670-1. PMID: 8571134.
      View in: PubMed
    36. Barker E, Fujimura SF, Fadem MB, Landay AL, Levy JA. Immunologic abnormalities associated with chronic fatigue syndrome. Clin Infect Dis. 1994 Jan; 18 Suppl 1:S136-41. PMID: 8148441.
      View in: PubMed
    37. Weiskirch LM, Baumgartel BA, Barker E, Mokyr MB. Phorbol ester-induced enhancement in lytic activity of CD8+ splenic T cells from low-dose melphalan-treated MOPC-315-tumor bearers. Cancer Immunol Immunother. 1991; 32(6):353-63. PMID: 1901031.
      View in: PubMed
    38. Barker E, Mueller BM, Handgretinger R, Herter M, Yu AL, Reisfeld RA. Effect of a chimeric anti-ganglioside GD2 antibody on cell-mediated lysis of human neuroblastoma cells. Cancer Res. 1991 Jan 01; 51(1):144-9. PMID: 1988079.
      View in: PubMed
    39. Weiskirch LM, Barker E, Mokyr MB. Eradication of a large MOPC-315 tumor in athymic nude mice by chemoimmunotherapy with Lyt2+ splenic T cells from melphalan-treated BALB/c mice bearing a large MOPC-315 tumor. Cancer Immunol Immunother. 1990; 31(3):129-38. PMID: 2337902.
      View in: PubMed
    40. Barker E, Wise JA, Dray S, Mokyr MB. Lysis of antigenically unrelated tumor cells mediated by Lyt 2+ splenic T-cells from melphalan-cured MOPC-315 tumor bearers. Cancer Res. 1989 Sep 15; 49(18):5007-15. PMID: 2788494.
      View in: PubMed
    41. Mokyr MB, Barker E, Weiskirch LM, Takesue BY, Pyle JM. Importance of Lyt 2+ T-cells in the curative effectiveness of a low dose of melphalan for mice bearing a large MOPC-315 tumor. Cancer Res. 1989 Aug 15; 49(16):4597-606. PMID: 2568174.
      View in: PubMed
    42. Barker E, Mokyr MB. Importance of Lyt-2+ T-cells in the resistance of melphalan-cured MOPC-315 tumor bearers to a challenge with MOPC-315 tumor cells. Cancer Res. 1988 Sep 01; 48(17):4834-42. PMID: 3261626.
      View in: PubMed
    43. Barker E, Mokyr MB. Some characteristics of the in vivo antitumor immunity exhibited by mice cured of a large MOPC-315 tumor by a low dose of melphalan. Cancer Immunol Immunother. 1987; 25(3):215-24. PMID: 3677124.
      View in: PubMed
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