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Ed Barker

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-942-3136
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 7103411264.
    My NIH COMMONS name is BARKERE.

    Research Areas:
    Natural killer cells and HIV, innate lymphoid cells in HIV infection.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/edward-barker-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/46831905/?sort=date&direction=descending

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7103411264

    Education:
    PhD, University of Illinois


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Barker ED, Cecil CAM, Walton E, Houtepen LC, O'Connor TG, Danese A, Jaffee SR, Jensen SKG, Pariante C, McArdle W, Gaunt TR, Relton CL, Roberts S. Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence. Dev Psychopathol. 2018 08; 30(3):1145-1156. PMID: 30068408.
      View in: PubMed
    2. Barker ED, Roberts S, Walton E. Hidden hypotheses in 'hypothesis-free' genome-wide epigenetic associations. Curr Opin Psychol. 2018 Jul 25; 27:13-17. PMID: 30077874.
      View in: PubMed
    3. Lim KX, Liu CY, Schoeler T, Cecil CAM, Barker ED, Viding E, Greven CU, Pingault JB. The role of birth weight on the causal pathway to child and adolescent ADHD symptomatology: a population-based twin differences longitudinal design. J Child Psychol Psychiatry. 2018 Jul 12. PMID: 29999186.
      View in: PubMed
    4. Cecil CAM, McCrory EJ, Barker ED, Guiney J, Viding E. Characterising youth with callous-unemotional traits and concurrent anxiety: evidence for a high-risk clinical group. Eur Child Adolesc Psychiatry. 2018 Jul; 27(7):885-898. PMID: 29222633.
      View in: PubMed
    5. Dillon SM, Castleman MJ, Frank DN, Austin GL, Gianella S, Cogswell AC, Landay AL, Barker E, Wilson CC. Brief Report: Inflammatory Colonic Innate Lymphoid Cells Are Increased During Untreated HIV-1 Infection and Associated With Markers of Gut Dysbiosis and Mucosal Immune Activation. J Acquir Immune Defic Syndr. 2017 Dec 01; 76(4):431-437. PMID: 28825942.
      View in: PubMed
    6. Jensen SKG, Pangelinan M, Björnholm L, Klasnja A, Leemans A, Drakesmith M, Evans CJ, Barker ED, Paus T. Associations between prenatal, childhood, and adolescent stress and variations in white-matter properties in young men. Neuroimage. 2017 Oct 21. PMID: 29066395.
      View in: PubMed
    7. Barker ED, Walton E, Cecil CAM. Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology. J Child Psychol Psychiatry. 2018 Apr; 59(4):303-322. PMID: 28736860.
      View in: PubMed
    8. Mesirow MS, Cecil C, Maughan B, Barker ED. Associations between Prenatal and Early Childhood Fish and Processed Food Intake, Conduct Problems, and Co-Occurring Difficulties. J Abnorm Child Psychol. 2017 Jul; 45(5):1039-1049. PMID: 27812905.
      View in: PubMed
    9. Quinlan EB, Cattrell A, Jia T, Artiges E, Banaschewski T, Barker G, Bokde ALW, Bromberg U, Büchel C, Brühl R, Conrod PJ, Desrivieres S, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Martinot JL, Paillère Martinot ML, Nees F, Papadopoulos-Orfanos D, Paus T, Poustka L, Smolka MN, Vetter NC, Walter H, Whelan R, Glennon JC, Buitelaar JK, Happé F, Loth E, Barker ED, Schumann G. Psychosocial Stress and Brain Function in Adolescent Psychopathology. Am J Psychiatry. 2017 08 01; 174(8):785-794. PMID: 28618856.
      View in: PubMed
    10. Walton E, Cecil CAM, Suderman M, Liu J, Turner JA, Calhoun V, Ehrlich S, Relton CL, Barker ED. Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio. J Child Psychol Psychiatry. 2017 Dec; 58(12):1341-1350. PMID: 28480579.
      View in: PubMed
    11. Meehan AJ, Maughan B, Cecil CAM, Barker ED. Interpersonal callousness and co-occurring anxiety: Developmental validity of an adolescent taxonomy. J Abnorm Psychol. 2017 Feb; 126(2):225-236. PMID: 27977232.
      View in: PubMed
    12. Cecil CA, Walton E, Smith RG, Viding E, McCrory EJ, Relton CL, Suderman M, Pingault JB, McArdle W, Gaunt TR, Mill J, Barker ED. DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence. Transl Psychiatry. 2016 12 06; 6(12):e976. PMID: 27922636.
      View in: PubMed
    13. Cecil CA, Walton E, Barker ED. Prenatal diet and childhood ADHD: exploring the potential role of IGF2 methylation. Epigenomics. 2016 12; 8(12):1573-1576. PMID: 27855496.
      View in: PubMed
    14. Garrido C, Spivak AM, Soriano-Sarabia N, Checkley MA, Barker E, Karn J, Planelles V, Margolis DM. HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function. Front Immunol. 2016; 7:356. PMID: 27708642.
      View in: PubMed
    15. Davis ZB, Sowrirajan B, Cogswell A, Ward JP, Planelles V, Barker E. CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells. AIDS Res Hum Retroviruses. 2017 02; 33(2):93-100. PMID: 27296670.
      View in: PubMed
    16. Mowlem FD, Skirrow C, Reid P, Maltezos S, Nijjar SK, Merwood A, Barker E, Cooper R, Kuntsi J, Asherson P. Validation of the Mind Excessively Wandering Scale and the Relationship of Mind Wandering to Impairment in Adult ADHD. J Atten Disord. 2016 Jun 02. PMID: 27255536.
      View in: PubMed
    17. Walton E, Pingault JB, Cecil CA, Gaunt TR, Relton CL, Mill J, Barker ED. Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study. Mol Psychiatry. 2017 02; 22(2):250-256. PMID: 27217153.
      View in: PubMed
    18. Barker E, Evans DT. HLA-C Downmodulation by HIV-1 Vpu. Cell Host Microbe. 2016 05 11; 19(5):570-1. PMID: 27173922.
      View in: PubMed
    19. Boudreau JE, Mulrooney TJ, Le Luduec JB, Barker E, Hsu KC. KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV. J Immunol. 2016 Apr 15; 196(8):3398-410. PMID: 26962229; PMCID: PMC4868784 [Available on 04/15/17].
    20. Davis ZB, Cogswell A, Scott H, Mertsching A, Boucau J, Wambua D, Le Gall S, Planelles V, Campbell KS, Barker E. A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells. PLoS Pathog. 2016 Feb; 12(2):e1005421. PMID: 26828202; PMCID: PMC4735451.
    21. Jensen SK, Dickie EW, Schwartz DH, Evans CJ, Dumontheil I, Paus T, Barker ED. Effect of Early Adversity and Childhood Internalizing Symptoms on Brain Structure in Young Men. JAMA Pediatr. 2015 Oct; 169(10):938-46. PMID: 26280410.
      View in: PubMed
    22. Ramirez PW, DePaula-Silva AB, Szaniawski M, Barker E, Bosque A, Planelles V. HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins. Retrovirology. 2015 Jul 28; 12:65. PMID: 26215564; PMCID: PMC4517359.
    23. Pina-Camacho L, Jensen SK, Gaysina D, Barker ED. Maternal depression symptoms, unhealthy diet and child emotional-behavioural dysregulation. Psychol Med. 2015 Jul; 45(9):1851-60. PMID: 25524365.
      View in: PubMed
    24. Cassiday PA, DePaula-Silva AB, Chumley J, Ward J, Barker E, Planelles V. Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx. Virology. 2015 Feb; 476:19-25. PMID: 25499532; PMCID: PMC4323848.
    25. Cecil CA, Lysenko LJ, Jaffee SR, Pingault JB, Smith RG, Relton CL, Woodward G, McArdle W, Mill J, Barker ED. Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study. Mol Psychiatry. 2014 Oct; 19(10):1071-7. PMID: 25199917.
      View in: PubMed
    26. Ramirez PW, Famiglietti M, Sowrirajan B, DePaula-Silva AB, Rodesch C, Barker E, Bosque A, Planelles V. Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4? T cells. Cell Rep. 2014 Jun 26; 7(6):2019-30. PMID: 24910430; PMCID: PMC4080720.
    27. Dillon SM, Lee EJ, Bramante JM, Barker E, Wilson CC. The natural killer cell interferon-gamma response to bacteria is diminished in untreated HIV-1 infection and defects persist despite viral suppression. J Acquir Immune Defic Syndr. 2014 Mar 01; 65(3):259-67. PMID: 24091697; PMCID: PMC3945425.
    28. Kretschmer T, Vitaro F, Barker ED. The Association Between Peer and own Aggression is Moderated by the BDNF Val-met Polymorphism. J Res Adolesc. 2014 Mar; 24(1):177-185. PMID: 25061266.
      View in: PubMed
    29. McAdams TA, Salekin RT, Marti CN, Lester WS, Barker ED. Co-occurrence of antisocial behavior and substance use: testing for sex differences in the impact of older male friends, low parental knowledge and friends' delinquency. J Adolesc. 2014 Apr; 37(3):247-56. PMID: 24636685.
      View in: PubMed
    30. Barker ED, Kirkham N, Ng J, Jensen SK. Prenatal maternal depression symptoms and nutrition, and child cognitive function. Br J Psychiatry. 2013 Dec; 203(6):417-21. PMID: 24115347.
      View in: PubMed
    31. Jensen SK, Dumontheil I, Barker ED. Developmental inter-relations between early maternal depression, contextual risks, and interpersonal stress, and their effect on later child cognitive functioning. Depress Anxiety. 2014 Jul; 31(7):599-607. PMID: 24027237.
      View in: PubMed
    32. Barker ED, McAuliffe FM, Alderdice F, Unterscheider J, Daly S, Geary MP, Kennelly MM, O'Donoghue K, Hunter A, Morrison JJ, Burke G, Dicker P, Tully EC, Malone FD. The role of growth trajectories in classifying fetal growth restriction. Obstet Gynecol. 2013 Aug; 122(2 Pt 1):248-54. PMID: 23969791.
      View in: PubMed
    33. Sauter D, Unterweger D, Vogl M, Usmani SM, Heigele A, Kluge SF, Hermkes E, Moll M, Barker E, Peeters M, Learn GH, Bibollet-Ruche F, Fritz JV, Fackler OT, Hahn BH, Kirchhoff F. Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein. PLoS Pathog. 2012 Dec; 8(12):e1003093. PMID: 23308067; PMCID: PMC3534379.
    34. Plant DT, Barker ED, Waters CS, Pawlby S, Pariante CM. Intergenerational transmission of maltreatment and psychopathology: the role of antenatal depression. Psychol Med. 2013 Mar; 43(3):519-28. PMID: 22694795; PMCID: PMC3558981.
    35. Manion M, Rodriguez B, Medvik K, Hardy G, Harding CV, Schooley RT, Pollard R, Asmuth D, Murphy R, Barker E, Brady KE, Landay A, Funderburg N, Sieg SF, Lederman MM. Interferon-alpha administration enhances CD8+ T cell activation in HIV infection. PLoS One. 2012; 7(1):e30306. PMID: 22291932; PMCID: PMC3265460.
    36. Sowrirajan B, Barker E. The natural killer cell cytotoxic function is modulated by HIV-1 accessory proteins. Viruses. 2011 07; 3(7):1091-111. PMID: 21994772; PMCID: PMC3185792.
    37. Davis ZB, Ward JP, Barker E. Preparation and use of HIV-1 infected primary CD4+ T-cells as target cells in natural killer cell cytotoxic assays. J Vis Exp. 2011 Mar 14; (49). PMID: 21445040; PMCID: PMC3197326.
    38. Oliver BR, Barker ED, Mandy WP, Skuse DH, Maughan B. Social cognition and conduct problems: a developmental approach. J Am Acad Child Adolesc Psychiatry. 2011 Apr; 50(4):385-94. PMID: 21421178.
      View in: PubMed
    39. Shah AH, Sowrirajan B, Davis ZB, Ward JP, Campbell EM, Planelles V, Barker E. Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu. Cell Host Microbe. 2010 Nov 18; 8(5):397-409. PMID: 21075351; PMCID: PMC3005698.
    40. Planelles V, Barker E. Roles of Vpr and Vpx in modulating the virus-host cell relationship. Mol Aspects Med. 2010 Oct; 31(5):398-406. PMID: 20558198; PMCID: PMC2967654.
    41. Ward J, Davis Z, DeHart J, Zimmerman E, Bosque A, Brunetta E, Mavilio D, Planelles V, Barker E. HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response. PLoS Pathog. 2009 Oct; 5(10):e1000613. PMID: 19798433; PMCID: PMC2747015.
    42. Barker ED, Arseneault L, Brendgen M, Fontaine N, Maughan B. Joint development of bullying and victimization in adolescence: relations to delinquency and self-harm. J Am Acad Child Adolesc Psychiatry. 2008 Sep; 47(9):1030-8. PMID: 18665001.
      View in: PubMed
    43. Fogli M, Mavilio D, Brunetta E, Varchetta S, Ata K, Roby G, Kovacs C, Follmann D, Pende D, Ward J, Barker E, Marcenaro E, Moretta A, Fauci AS. Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals. PLoS Pathog. 2008 Jul 11; 4(7):e1000101. PMID: 18617991; PMCID: PMC2438610.
    44. Fontaine N, Barker ED, Salekin RT, Viding E. Dimensions of psychopathy and their relationships to cognitive functioning in children. J Clin Child Adolesc Psychol. 2008 Jul; 37(3):690-6. PMID: 18645759.
      View in: PubMed
    45. Ward J, Barker E. Role of natural killer cells in HIV pathogenesis. Curr HIV/AIDS Rep. 2008 Feb; 5(1):44-50. PMID: 18417035.
      View in: PubMed
    46. Barker E, Martinson J, Brooks C, Landay A, Deeks S. Dysfunctional natural killer cells, in vivo, are governed by HIV viremia regardless of whether the infected individual is on antiretroviral therapy. AIDS. 2007 Nov 12; 21(17):2363-5. PMID: 18090295.
      View in: PubMed
    47. Banerjee P, Feuer G, Barker E. Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells. J Virol. 2007 Sep; 81(18):9707-17. PMID: 17609265; PMCID: PMC2045425.
    48. Ward J, Bonaparte M, Sacks J, Guterman J, Fogli M, Mavilio D, Barker E. HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. Blood. 2007 Aug 15; 110(4):1207-14. PMID: 17513617; PMCID: PMC1939902.
    49. Pang J, Cheng M, Haire SE, Barker E, Planelles V, Blanks JC. Efficiency of lentiviral transduction during development in normal and rd mice. Mol Vis. 2006 Jul 11; 12:756-67. PMID: 16862069.
      View in: PubMed
    50. Ward JP, Bonaparte MI, Barker E. HLA-C and HLA-E reduce antibody-dependent natural killer cell-mediated cytotoxicity of HIV-infected primary T cell blasts. AIDS. 2004 Sep 03; 18(13):1769-79. PMID: 15316337.
      View in: PubMed
    51. Bonaparte MI, Barker E. Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility complex class I molecules. Blood. 2004 Oct 01; 104(7):2087-94. PMID: 15117765.
      View in: PubMed
    52. Barker E, Planelles V. Vectors derived from the human immunodeficiency virus, HIV-1. Front Biosci. 2003 May 01; 8:d491-510. PMID: 12700118.
      View in: PubMed
    53. Bonaparte MI, Barker E. Inability of natural killer cells to destroy autologous HIV-infected T lymphocytes. AIDS. 2003 Mar 07; 17(4):487-94. PMID: 12598768.
      View in: PubMed
    54. Wrzesinski S, Séguin R, Liu Y, Domville S, Planelles V, Massa P, Barker E, Antel J, Feuer G. HTLV type 1 Tax transduction in microglial cells and astrocytes by lentiviral vectors. AIDS Res Hum Retroviruses. 2000 Nov 01; 16(16):1771-6. PMID: 11080825.
      View in: PubMed
    55. Barker E, Bossart KN, Fujimura SH, Levy JA. The role of CD80 and CD86 in enhancing CD8(+) cell suppression of HIV replication. Cell Immunol. 1999 Sep 15; 196(2):95-103. PMID: 10527561.
      View in: PubMed
    56. Greco G, Barker E, Levy JA. Differences in HIV replication in CD4+ lymphocytes are not related to beta-chemokine production. AIDS Res Hum Retroviruses. 1998 Nov 01; 14(16):1407-11. PMID: 9824318.
      View in: PubMed
    57. Barker E, Bossart KN, Levy JA. Primary CD8+ cells from HIV-infected individuals can suppress productive infection of macrophages independent of beta-chemokines. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1725-9. PMID: 9465084; PMCID: PMC19166.
    58. Barker E, Bossart KN, Locher CP, Patterson BK, Levy JA. CD8+ cells from asymptomatic human immunodeficiency virus-infected individuals suppress superinfection of their peripheral blood mononuclear cells. J Gen Virol. 1996 Dec; 77 ( Pt 12):2953-62. PMID: 9000085.
      View in: PubMed
    59. Levy JA, Ramachandran B, Barker E, Guthrie J, Elbeik T. Plasma viral load, CD4+ cell counts, and HIV-1 production by cells. Science. 1996 Feb 02; 271(5249):670-1. PMID: 8571134.
      View in: PubMed
    60. Barker E, Fujimura SF, Fadem MB, Landay AL, Levy JA. Immunologic abnormalities associated with chronic fatigue syndrome. Clin Infect Dis. 1994 Jan; 18 Suppl 1:S136-41. PMID: 8148441.
      View in: PubMed
    61. Weiskirch LM, Baumgartel BA, Barker E, Mokyr MB. Phorbol ester-induced enhancement in lytic activity of CD8+ splenic T cells from low-dose melphalan-treated MOPC-315-tumor bearers. Cancer Immunol Immunother. 1991; 32(6):353-63. PMID: 1901031.
      View in: PubMed
    62. Barker E, Mueller BM, Handgretinger R, Herter M, Yu AL, Reisfeld RA. Effect of a chimeric anti-ganglioside GD2 antibody on cell-mediated lysis of human neuroblastoma cells. Cancer Res. 1991 Jan 01; 51(1):144-9. PMID: 1988079.
      View in: PubMed
    63. Weiskirch LM, Barker E, Mokyr MB. Eradication of a large MOPC-315 tumor in athymic nude mice by chemoimmunotherapy with Lyt2+ splenic T cells from melphalan-treated BALB/c mice bearing a large MOPC-315 tumor. Cancer Immunol Immunother. 1990; 31(3):129-38. PMID: 2337902.
      View in: PubMed
    64. Barker E, Wise JA, Dray S, Mokyr MB. Lysis of antigenically unrelated tumor cells mediated by Lyt 2+ splenic T-cells from melphalan-cured MOPC-315 tumor bearers. Cancer Res. 1989 Sep 15; 49(18):5007-15. PMID: 2788494.
      View in: PubMed
    65. Mokyr MB, Barker E, Weiskirch LM, Takesue BY, Pyle JM. Importance of Lyt 2+ T-cells in the curative effectiveness of a low dose of melphalan for mice bearing a large MOPC-315 tumor. Cancer Res. 1989 Aug 15; 49(16):4597-606. PMID: 2568174.
      View in: PubMed
    66. Barker E, Mokyr MB. Importance of Lyt-2+ T-cells in the resistance of melphalan-cured MOPC-315 tumor bearers to a challenge with MOPC-315 tumor cells. Cancer Res. 1988 Sep 01; 48(17):4834-42. PMID: 3261626.
      View in: PubMed
    67. Barker E, Mokyr MB. Some characteristics of the in vivo antitumor immunity exhibited by mice cured of a large MOPC-315 tumor by a low dose of melphalan. Cancer Immunol Immunother. 1987; 25(3):215-24. PMID: 3677124.
      View in: PubMed
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