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Dan Predescu

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Pulmonary Disease Critical Care
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 6701639380.
    My NIH COMMONS name is DPREDESCU.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Predescu DN, Mokhlesi B, Predescu SA. The Impact of Sex Chromosomes in the Sexual Dimorphism of Pulmonary Arterial Hypertension. Am J Pathol. 2022 04; 192(4):582-594. PMID: 35114193.
      View in: PubMed
    2. Qin S, Predescu D, Carman B, Patel P, Chen J, Kim M, Lahm T, Geraci M, Predescu SA. Up-Regulation of the Long Noncoding RNA X-Inactive-Specific Transcript and the Sex Bias in Pulmonary Arterial Hypertension. Am J Pathol. 2021 06; 191(6):1135-1150. PMID: 33836164.
      View in: PubMed
    3. Qin S, Predescu DN, Patel M, Drazkowski P, Ganesh B, Predescu SA. Sex differences in the proliferation of pulmonary artery endothelial cells: implications for plexiform arteriopathy. J Cell Sci. 2020 05 14; 133(9). PMID: 32409569.
      View in: PubMed
    4. Shah TG, Predescu D, Predescu S. Mesenchymal stem cells-derived extracellular vesicles in acute respiratory distress syndrome: a review of current literature and potential future treatment options. Clin Transl Med. 2019 Sep 12; 8(1):25. PMID: 31512000.
      View in: PubMed
    5. Carman BL, Predescu DN, Machado R, Predescu SA. Plexiform Arteriopathy in Rodent Models of Pulmonary Arterial Hypertension. Am J Pathol. 2019 06; 189(6):1133-1144. PMID: 30926336.
      View in: PubMed
    6. Predescu D, Qin S, Patel M, Bardita C, Bhalli R, Predescu S. Epsin15 Homology Domains: Role in the Pathogenesis of Pulmonary Arterial Hypertension. Front Physiol. 2018; 9:1393. PMID: 30333761.
      View in: PubMed
    7. Shah T, Qin S, Vashi M, Predescu DN, Jeganathan N, Bardita C, Ganesh B, diBartolo S, Fogg LF, Balk RA, Predescu SA. Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome. Clin Transl Med. 2018 Jun 22; 7(1):19. PMID: 29931538.
      View in: PubMed
    8. Jeganathan N, Predescu D, Predescu S. Intersectin-1s deficiency in pulmonary pathogenesis. Respir Res. 2017 09 06; 18(1):168. PMID: 28874189.
      View in: PubMed
    9. Chan DD, Li J, Luo W, Predescu DN, Cole BJ, Plaas A. Pirfenidone reduces subchondral bone loss and fibrosis after murine knee cartilage injury. J Orthop Res. 2018 01; 36(1):365-376. PMID: 28646530.
      View in: PubMed
    10. Predescu SA, Zhang J, Bardita C, Patel M, Godbole V, Predescu DN. Mouse Lung Fibroblast Resistance to Fas-Mediated Apoptosis Is Dependent on the Baculoviral Inhibitor of Apoptosis Protein 4 and the Cellular FLICE-Inhibitory Protein. Front Physiol. 2017; 8:128. PMID: 28352235.
      View in: PubMed
    11. Patel M, Predescu D, Bardita C, Chen J, Jeganathan N, Pritchard M, DiBartolo S, Machado R, Predescu S. Modulation of Intersectin-1s Lung Expression Induces Obliterative Remodeling and Severe Plexiform Arteriopathy in the Murine Pulmonary Vascular Bed. Am J Pathol. 2017 Mar; 187(3):528-542. PMID: 28068512.
      View in: PubMed
    12. Jeganathan N, Predescu D, Zhang J, Sha F, Bardita C, Patel M, Wood S, Borgia JA, Balk RA, Predescu S. Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis. Mol Cancer. 2016 09 14; 15(1):59. PMID: 27629044.
      View in: PubMed
    13. Tran KA, Zhang X, Predescu D, Huang X, Machado RF, Göthert JR, Malik AB, Valyi-Nagy T, Zhao YY. Endothelial ß-Catenin Signaling Is Required for Maintaining Adult Blood-Brain Barrier Integrity and Central Nervous System Homeostasis. Circulation. 2016 Jan 12; 133(2):177-86. PMID: 26538583.
      View in: PubMed
    14. Predescu S, Bardita C, Predescu D. New insights into the functions of intersectin-1s. Commun Integr Biol. 2015 May-Jun; 8(3):e1034400. PMID: 26479042.
      View in: PubMed
    15. Lockett AD, Petrusca DN, Justice MJ, Poirier C, Serban KA, Rush NI, Kamocka M, Predescu D, Predescu S, Petrache I. Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15; 309(4):L425-34. PMID: 26092999.
      View in: PubMed
    16. Bardita C, Predescu DN, Sha F, Patel M, Balaji G, Predescu SA. Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5. J Cell Sci. 2015 Apr 15; 128(8):1528-41. PMID: 25720380.
      View in: PubMed
    17. Predescu DN, Bardita C, Tandon R, Predescu SA. Intersectin-1s: an important regulator of cellular and molecular pathways in lung injury. Pulm Circ. 2013 Sep; 3(3):478-98. PMID: 24618535.
      View in: PubMed
    18. Predescu S, Knezevic I, Bardita C, Neamu RF, Brovcovych V, Predescu D. Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. PLoS One. 2013; 8(9):e75846. PMID: 24086643.
      View in: PubMed
    19. Patel M, Predescu D, Tandon R, Bardita C, Pogoriler J, Bhorade S, Wang M, Comhair S, Ryan-Hemnes A, Chen J, Machado R, Husain A, Erzurum S, Predescu S. A novel p38 mitogen-activated protein kinase/Elk-1 transcription factor-dependent molecular mechanism underlying abnormal endothelial cell proliferation in plexogenic pulmonary arterial hypertension. J Biol Chem. 2013 Sep 06; 288(36):25701-25716. PMID: 23893408.
      View in: PubMed
    20. Bardita C, Predescu D, Predescu S. Long-term silencing of intersectin-1s in mouse lungs by repeated delivery of a specific siRNA via cationic liposomes. Evaluation of knockdown effects by electron microscopy. J Vis Exp. 2013 Jun 21; (76). PMID: 23851900.
      View in: PubMed
    21. Bardita C, Predescu D, Justice MJ, Petrache I, Predescu S. In vivo knockdown of intersectin-1s alters endothelial cell phenotype and causes microvascular remodeling in the mouse lungs. Apoptosis. 2013 Jan; 18(1):57-76. PMID: 23054079.
      View in: PubMed
    22. Predescu DN, Neamu R, Bardita C, Wang M, Predescu SA. Impaired caveolae function and upregulation of alternative endocytic pathways induced by experimental modulation of intersectin-1s expression in mouse lung endothelium. Biochem Res Int. 2012; 2012:672705. PMID: 22506115.
      View in: PubMed
    23. Knezevic I, Predescu D, Bardita C, Wang M, Sharma T, Keith B, Neamu R, Malik AB, Predescu S. Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s. J Cell Mol Med. 2011 Nov; 15(11):2364-76. PMID: 21129155.
      View in: PubMed
    24. Singla S, Predescu D, Bardita C, Wang M, Zhang J, Balk RA, Predescu S. Pro-inflammatory endothelial cell dysfunction is associated with intersectin-1s down-regulation. Respir Res. 2011 Apr 12; 12:46. PMID: 21486462.
      View in: PubMed
    25. Gorovoy M, Han J, Pan H, Welch E, Neamu R, Jia Z, Predescu D, Vogel S, Minshall RD, Ye RD, Malik AB, Voyno-Yasenetskaya T. LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs. Circ Res. 2009 Sep 11; 105(6):549-56. PMID: 19679840.
      View in: PubMed
    26. Klein IK, Predescu DN, Sharma T, Knezevic I, Malik AB, Predescu S. Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization. J Biol Chem. 2009 Sep 18; 284(38):25953-61. PMID: 19622753.
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    27. Knezevic II, Predescu SA, Neamu RF, Gorovoy MS, Knezevic NM, Easington C, Malik AB, Predescu DN. Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability. J Biol Chem. 2009 Feb 20; 284(8):5381-94. PMID: 19095647.
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    28. Tiruppathi C, Shimizu J, Miyawaki-Shimizu K, Vogel SM, Bair AM, Minshall RD, Predescu D, Malik AB. Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide. J Biol Chem. 2008 Feb 15; 283(7):4210-8. PMID: 18077459.
      View in: PubMed
    29. Predescu SA, Predescu DN, Malik AB. Molecular determinants of endothelial transcytosis and their role in endothelial permeability. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L823-42. PMID: 17644753.
      View in: PubMed
    30. Gorovoy M, Neamu R, Niu J, Vogel S, Predescu D, Miyoshi J, Takai Y, Kini V, Mehta D, Malik AB, Voyno-Yasenetskaya T. RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs. Circ Res. 2007 Jul 06; 101(1):50-8. PMID: 17525371.
      View in: PubMed
    31. Predescu SA, Predescu DN, Knezevic I, Klein IK, Malik AB. Intersectin-1s regulates the mitochondrial apoptotic pathway in endothelial cells. J Biol Chem. 2007 Jun 08; 282(23):17166-78. PMID: 17405881.
      View in: PubMed
    32. Ong E, Gao XP, Predescu D, Broman M, Malik AB. Role of phosphatidylinositol 3-kinase-gamma in mediating lung neutrophil sequestration and vascular injury induced by E. coli sepsis. Am J Physiol Lung Cell Mol Physiol. 2005 Dec; 289(6):L1094-103. PMID: 16183669.
      View in: PubMed
    33. Miyawaki-Shimizu K, Predescu D, Shimizu J, Broman M, Predescu S, Malik AB. siRNA-induced caveolin-1 knockdown in mice increases lung vascular permeability via the junctional pathway. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L405-13. PMID: 16183667.
      View in: PubMed
    34. Predescu D, Predescu S, Shimizu J, Miyawaki-Shimizu K, Malik AB. Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. Am J Physiol Lung Cell Mol Physiol. 2005 Sep; 289(3):L371-81. PMID: 16093363.
      View in: PubMed
    35. Predescu SA, Predescu DN, Shimizu K, Klein IK, Malik AB. Cholesterol-dependent syntaxin-4 and SNAP-23 clustering regulates caveolar fusion with the endothelial plasma membrane. J Biol Chem. 2005 Nov 04; 280(44):37130-8. PMID: 16118213.
      View in: PubMed
    36. Gao XP, Liu Q, Broman M, Predescu D, Frey RS, Malik AB. Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury. Physiol Genomics. 2005 Apr 14; 21(2):230-42. PMID: 15831844.
      View in: PubMed
    37. Predescu D, Vogel SM, Malik AB. Functional and morphological studies of protein transcytosis in continuous endothelia. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L895-901. PMID: 15475492.
      View in: PubMed
    38. Predescu SA, Predescu DN, Timblin BK, Stan RV, Malik AB. Intersectin regulates fission and internalization of caveolae in endothelial cells. Mol Biol Cell. 2003 Dec; 14(12):4997-5010. PMID: 12960435.
      View in: PubMed
    39. Ong ES, Gao XP, Xu N, Predescu D, Rahman A, Broman MT, Jho DH, Malik AB. E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeability. Am J Physiol Lung Cell Mol Physiol. 2003 Oct; 285(4):L879-88. PMID: 12818890.
      View in: PubMed
    40. Predescu D, Predescu S, Malik AB. Transport of nitrated albumin across continuous vascular endothelium. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13932-7. PMID: 12370442.
      View in: PubMed
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