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Rachel Miller

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentRheumatology
Address
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    Collapse Overview 
    Collapse overview
    Education
    PhD in Biological Engineering, Massachusetts Institute of Technology
    BS in Bioengineering, Pennsylvania State University

    Areas of Expertise
    Biomechanical pain pathways in osteoarthritis
    Musculoskeletal pain
    Peripheral nervous system
    Rodent behavioral assessments

    For more information, please see the lab website: www.annemariemalfait.com
    or our Chicago Center on Musculoskeletal Pain website:
    https://mskpain.center/

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Syx D, Miller RE, Obeidat AM, Tran PB, Vroman R, Malfait Z, Miller RJ, Malfait F, Malfait AM. Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome. Pain. 2020 10; 161(10):2274-2283. PMID: 32483055.
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    2. Malfait AM, Miller RE, Block JA. Targeting neurotrophic factors: Novel approaches to musculoskeletal pain. Pharmacol Ther. 2020 07; 211:107553. PMID: 32311372.
      Citations:    
    3. Miller RE, Tran PB, Ishihara S, Syx D, Ren D, Miller RJ, Valdes AM, Malfait AM. Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis. Osteoarthritis Cartilage. 2020 05; 28(5):581-592. PMID: 31982564.
      Citations:    
    4. Malfait AM, Miller RE. Why we should study osteoarthritis pain in experimental models in both sexes. Osteoarthritis Cartilage. 2020 04; 28(4):397-399. PMID: 31926266.
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    5. Miller RJ, Malfait AM, Miller RE. The innate immune response as a mediator of osteoarthritis pain. Osteoarthritis Cartilage. 2020 05; 28(5):562-571. PMID: 31862470.
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    6. Miller RE, Scanzello CR, Malfait AM. An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis. Semin Immunopathol. 2019 09; 41(5):583-594. PMID: 31612243.
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    7. Obeidat AM, Miller RE, Miller RJ, Malfait AM. The nociceptive innervation of the normal and osteoarthritic mouse knee. Osteoarthritis Cartilage. 2019 11; 27(11):1669-1679. PMID: 31351964.
      Citations:    
    8. Miller RE, Block JA, Malfait AM. What is new in pain modification in osteoarthritis? Rheumatology (Oxford). 2018 05 01; 57(suppl_4):iv99-iv107. PMID: 29361112.
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    9. Miller RE, Malfait AM. Osteoarthritis pain: What are we learning from animal models? Best Pract Res Clin Rheumatol. 2017 10; 31(5):676-687. PMID: 30509413.
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    10. Miller RE, Ishihara S, Tran PB, Golub SB, Last K, Miller RJ, Fosang AJ, Malfait AM. An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. JCI Insight. 2018 03 22; 3(6). PMID: 29563338.
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    11. Syx D, Tran PB, Miller RE, Malfait AM. Peripheral Mechanisms Contributing to Osteoarthritis Pain. Curr Rheumatol Rep. 2018 02 26; 20(2):9. PMID: 29480410.
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    12. Miller RE, Kim YS, Tran PB, Ishihara S, Dong X, Miller RJ, Malfait AM. Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging. Arthritis Rheumatol. 2018 01; 70(1):88-97. PMID: 28992367.
      Citations:    
    13. Wang X, Dande RR, Yu H, Samelko B, Miller RE, Altintas MM, Reiser J. TRPC5 Does Not Cause or Aggravate Glomerular Disease. J Am Soc Nephrol. 2018 02; 29(2):409-415. PMID: 29061651.
      Citations:    
    14. Miller RJ, Miller RE. Is cannabis an effective treatment for joint pain? Clin Exp Rheumatol. 2017 Sep-Oct; 35 Suppl 107(5):59-67. PMID: 28967368.
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    15. Miller RE, Malfait AM, Block JA. Current status of nerve growth factor antibodies for the treatment of osteoarthritis pain. Clin Exp Rheumatol. 2017 Sep-Oct; 35 Suppl 107(5):85-87. PMID: 28967370.
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    16. Sambamurthy N, Nguyen V, Smalley R, Xiao R, Hankenson K, Gan J, Miller RE, Malfait AM, Dodge GR, Scanzello CR. Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. J Orthop Res. 2018 03; 36(3):864-875. PMID: 28767178.
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    17. Miller RE, Ishihara S, Bhattacharyya B, Delaney A, Menichella DM, Miller RJ, Malfait AM. Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis. Arthritis Rheumatol. 2017 07; 69(7):1429-1439. PMID: 28380690.
      Citations:    
    18. Miller RE, Malfait AM. Can we target CCR2 to treat osteoarthritis? The trick is in the timing! Osteoarthritis Cartilage. 2017 06; 25(6):799-801. PMID: 28189827.
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    19. Miller RE, Block JA, Malfait AM. Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models? Curr Opin Rheumatol. 2017 01; 29(1):110-118. PMID: 27672741.
      Citations:    
    20. Miotla Zarebska J, Chanalaris A, Driscoll C, Burleigh A, Miller RE, Malfait AM, Stott B, Vincent TL. CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy. Osteoarthritis Cartilage. 2017 03; 25(3):406-412. PMID: 27746376.
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    21. Tran PB, Miller RE, Ishihara S, Miller RJ, Malfait AM. Spinal microglial activation in a murine surgical model of knee osteoarthritis. Osteoarthritis Cartilage. 2017 05; 25(5):718-726. PMID: 27646532.
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    22. Miller RE, Belmadani A, Ishihara S, Tran PB, Ren D, Miller RJ, Malfait AM. Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through Toll-like receptor 4. Arthritis Rheumatol. 2015 Nov; 67(11):2933-43. PMID: 26245312.
      Citations:    
    23. Miller RE, Tran PB, Obeidat AM, Raghu P, Ishihara S, Miller RJ, Malfait AM. The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain. Curr Osteoporos Rep. 2015 Oct; 13(5):318-26. PMID: 26233284.
      Citations:    
    24. Miller RE, Tran PB, Ishihara S, Larkin J, Malfait AM. Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis. Osteoarthritis Cartilage. 2016 Feb; 24(2):299-306. PMID: 26410555.
      Citations:    
    25. Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, Zhou T, Yang J, Zhang Y, Martelli EE, Naga Prasad SV, Miller RE, Malfait AM, Zhou Y, Wu Q. PCSK6-mediated corin activation is essential for normal blood pressure. Nat Med. 2015 Sep; 21(9):1048-53. PMID: 26259032.
      Citations:    
    26. Larkin J, Lohr TA, Elefante L, Shearin J, Matico R, Su JL, Xue Y, Liu F, Genell C, Miller RE, Tran PB, Malfait AM, Maier CC, Matheny CJ. Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis Cartilage. 2015 Aug; 23(8):1254-66. PMID: 25800415.
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    27. Florine EM, Miller RE, Liebesny PH, Mroszczyk KA, Lee RT, Patwari P, Grodzinsky AJ. Delivering heparin-binding insulin-like growth factor 1 with self-assembling peptide hydrogels. Tissue Eng Part A. 2015 Feb; 21(3-4):637-46. PMID: 25231349.
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    28. Miller RE, Grodzinsky AJ, Barrett MF, Hung HH, Frank EH, Werpy NM, McIlwraith CW, Frisbie DD. Effects of the combination of microfracture and self-assembling Peptide filling on the repair of a clinically relevant trochlear defect in an equine model. J Bone Joint Surg Am. 2014 Oct 01; 96(19):1601-9. PMID: 25274785.
      Citations:    
    29. Miller RE, Miller RJ, Malfait AM. Osteoarthritis joint pain: the cytokine connection. Cytokine. 2014 Dec; 70(2):185-93. PMID: 25066335.
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    30. Miller RE, Lu Y, Tortorella MD, Malfait AM. Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets. Curr Rheumatol Rep. 2013 Aug; 15(8):350. PMID: 23926636.
      Citations:    
    31. Florine EM, Miller RE, Porter RM, Evans CH, Kurz B, Grodzinsky AJ. Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds. Cartilage. 2013 Jan 01; 4(1):63-74. PMID: 24533173.
      Citations:    
    32. Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Ren D, Miller RJ, Malfait AM. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20602-7. PMID: 23185004.
      Citations:    
    33. Miller RE, Kopesky PW, Grodzinsky AJ. Growth factor delivery through self-assembling peptide scaffolds. Clin Orthop Relat Res. 2011 Oct; 469(10):2716-24. PMID: 21503788.
      Citations:    
    34. Miller RE, Grodzinsky AJ, Cummings K, Plaas AH, Cole AA, Lee RT, Patwari P. Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate. Arthritis Rheum. 2010 Dec; 62(12):3686-94. PMID: 20722014.
      Citations:    
    35. Miller RE, Grodzinsky AJ, Vanderploeg EJ, Lee C, Ferris DJ, Barrett MF, Kisiday JD, Frisbie DD. Effect of self-assembling peptide, chondrogenic factors, and bone marrow-derived stromal cells on osteochondral repair. Osteoarthritis Cartilage. 2010 Dec; 18(12):1608-19. PMID: 20851201.
      Citations:    
    36. Tokunou T, Miller R, Patwari P, Davis ME, Segers VF, Grodzinsky AJ, Lee RT. Engineering insulin-like growth factor-1 for local delivery. FASEB J. 2008 Jun; 22(6):1886-93. PMID: 18285400.
      Citations:    
    37. Miller R, Guo Z, Vogler EA, Siedlecki CA. Plasma coagulation response to surfaces with nanoscale chemical heterogeneity. Biomaterials. 2006 Jan; 27(2):208-15. PMID: 16011849.
      Citations:    
    38. Guo Z, Bussard KM, Chatterjee K, Miller R, Vogler EA, Siedlecki CA. Mathematical modeling of material-induced blood plasma coagulation. Biomaterials. 2006 Feb; 27(5):796-806. PMID: 16099033.
      Citations:    
    39. Zhuo R, Miller R, Bussard KM, Siedlecki CA, Vogler EA. Procoagulant stimulus processing by the intrinsic pathway of blood plasma coagulation. Biomaterials. 2005 Jun; 26(16):2965-73. PMID: 15603791.
      Citations:    
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