 Aspartic Acid Endopeptidases
"Aspartic Acid Endopeptidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
| Descriptor ID |
D016282
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| MeSH Number(s) |
D08.811.277.656.074.500 D08.811.277.656.300.048
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| Concept/Terms |
Aspartic Acid Endopeptidases- Aspartic Acid Endopeptidases
- Acid Endopeptidases, Aspartic
- Endopeptidases, Aspartic Acid
- Aspartyl Endopeptidases
- Endopeptidases, Aspartyl
- Aspartic Endopeptidases
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Below are MeSH descriptors whose meaning is more general than "Aspartic Acid Endopeptidases".
Below are MeSH descriptors whose meaning is more specific than "Aspartic Acid Endopeptidases".
This graph shows the total number of publications written about "Aspartic Acid Endopeptidases" by people in this website by year, and whether "Aspartic Acid Endopeptidases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2013 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aspartic Acid Endopeptidases" by people in Profiles.
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He L, Loika Y, Park Y. Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease. Transl Psychiatry. 2021 02 26; 11(1):146.
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Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aß generation in Alzheimer's disease. Acta Neuropathol. 2016 08; 132(2):235-256.
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Sadleir KR, Bennett DA, Schneider JA, Vassar R. Elevated Aß42 in aged, non-demented individuals with cerebral atherosclerosis. Curr Alzheimer Res. 2013 Oct; 10(8):785-9.
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Kandalepas PC, Sadleir KR, Eimer WA, Zhao J, Nicholson DA, Vassar R. The Alzheimer's ß-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol. 2013 Sep; 126(3):329-52.
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Cai Y, Xiong K, Zhang XM, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Chu Y, Kordower JH, Yan XX. ß-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and ß-amyloid accumulation. Eur J Neurosci. 2010 Oct; 32(7):1223-38.
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Wang S, Wang R, Chen L, Bennett DA, Dickson DW, Wang DS. Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain. J Neurochem. 2010 Oct; 115(1):47-57.
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O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26; 60(6):988-1009.
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