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Markus A. Wimmer

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentOrthopedic Surgery
Address1611 W. Harrison St.
Chicago IL 60612
ORCID ORCID Icon0000-0001-6169-3873 Additional info
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    Additional Appointments:
    The Grainger Director of the Rush Arthritis and Orthopedics Institute
    Associate Chairman, Department of Orthopedics
    Professor, Departments of Cell & Molecular Medicine and Internal Medicine, Division of Rheumatology

    Overview:
    Dr. Wimmer’s research focuses on the phenomena between interacting surfaces in natural and artificial joints. His research interests have been in joint biomechanics as related to joint health. Early on in his career he started to apply the technical principles of tribology to natural joints in an effort to combine engineering practices with biological tools. In order to comprehend the effects of load and motion on cartilage, several custom apparati were developed that are now in research use worldwide. As such, the custom built equipment is successfully used for tissue engineering and cartilage wear related questions. Next to the Tribology lab, he is also directs the Rush Human Motion laboratory, so Dr. Wimmer has considerable experience in gait and related joint loading.

    My ORCID is 0000-0001-6169-3873.
    My Scopus ID is 7103054325.
    My NIH COMMONS name is mwimmer.

    Education:
    Dipl.-Ing. (MS.ME) Technical University of Munich

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Perrone M, Guidetti M, Galli M, Nho SJ, Wimmer MA, Malloy P. Hip joint contact forces are lower in people with femoroacetabular impingement syndrome during squat tasks. J Orthop Res. 2023 Nov 30. PMID: 38032092.
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    2. Anderson KD, Beckmann C, Heermant S, Ko FC, Dulion B, Tarhoni I, Borgia JA, Virdi AS, Wimmer MA, Sumner DR, Ross RD, Anderson KD, Beckmann C, Heermant S, Ko FC, Dulion B, Tarhoni I, Borgia JA, Virdi AS, Wimmer MA, Sumner DR, Ross RD. Zucker Diabetic-Sprague Dawley Rats Have Impaired Peri-Implant Bone Formation, Matrix Composition, and Implant Fixation Strength. JBMR Plus. 2023 Nov; 7(11):e10819. PMID: 38025036; PMCID: PMC10652173.
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    3. Ebinger K, Samelko L, Radice S, Hallab NJ, Wimmer MA. Translational Characterization of Macrophage Responses to Stable and Non-Stable CoCrMo Wear and Corrosion Debris Generated In-Situ for Total Hip Replacement. Biotribology (Oxf). 2023 Dec; 35-36. PMID: 37900899.
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    4. Mell SP, Yuh C, Nagel T, Chubinskaya S, Lundberg HJ, Wimmer MA. Development of a computational-experimental framework for enhanced mechanical characterization and cross-species comparison of the articular cartilage superficial zone. Comput Methods Biomech Biomed Engin. 2023 Sep 09; 1-5. PMID: 37688477.
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    5. Wimmer MA, Rad EM, Laurent MP, Pourzal R. Striated Pattern on Worn Surface of a Retrieved TKR Tibial Insert Stems from Microstructural Changes in the UHMWPE. Biotribology (Oxf). 2023 Dec; 35-36. PMID: 38053775.
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    6. Della Fara G, Markovics A, Radice S, Hamilton JL, Chiesa R, Sturm A, Angenendt K, Fischer A, Wimmer MA. Electrophoretic deposition of gentamicin and chitosan into titanium nanotubes to target periprosthetic joint infection. J Biomed Mater Res B Appl Biomater. 2023 09; 111(9):1697-1704. PMID: 37194725.
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    7. Ganguly A, Olmanson BA, Knowlton CB, Wimmer MA, Ferrigno C. Accuracy of the fully integrated Insole3's estimates of spatiotemporal parameters during walking. Med Eng Phys. 2023 01; 111:103925. PMID: 36792249.
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    8. Chastain K, Wach A, Pekmezian A, Wimmer MA, Warren RF, Torzilli PA, Chen T, Maher SA. ACL transection results in a posterior shift and increased velocity of contact on the medial tibial plateau. J Biomech. 2022 11; 144:111335. PMID: 36252309.
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    9. Cramer LA, Wimmer MA, Malloy P, O'Keefe JA, Knowlton CB, Ferrigno C. Validity and Reliability of the Insole3 Instrumented Shoe Insole for Ground Reaction Force Measurement during Walking and Running. Sensors (Basel). 2022 Mar 11; 22(6). PMID: 35336374.
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    10. Hamilton JL, Vashi M, Kishen EB, Fogg LF, Wimmer MA, Balk RA. The Association of an Alpha-2 Adrenergic Receptor Agonist and Mortality in Patients With COVID-19. Front Med (Lausanne). 2021; 8:797647. PMID: 35059419.
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    11. Radice S, Wimmer MA. Biotribometer for Assessment of Cell and Tissue Toxicity of Orthopedic Metal Implant Debris. Methods Mol Biol. 2022; 2394:713-725. PMID: 35094354.
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    12. Mell SP, Wimmer MA, Jacobs JJ, Lundberg HJ. Optimal surgical component alignment minimizes TKR wear - An in silico study with nine alignment parameters. J Mech Behav Biomed Mater. 2022 01; 125:104939. PMID: 34740015.
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    13. Radice S, Neto MQ, Fischer A, Wimmer MA. Nickel-free high-nitrogen austenitic steel outperforms CoCrMo alloy regarding tribocorrosion in simulated inflammatory synovial fluids. J Orthop Res. 2022 06; 40(6):1397-1408. PMID: 34449923.
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    14. Hamilton JL, Mohamed MF, Witt BR, Wimmer MA, Shafikhani SH. Therapeutic assessment of N-formyl-methionyl-leucyl-phenylalanine (fMLP) in reducing periprosthetic joint infection. Eur Cell Mater. 2021 08 26; 42:122-138. PMID: 34435345.
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    15. Yuh C, O'Bryan CS, Angelini TE, Wimmer MA. Microindentation of cartilage before and after articular loading in a bioreactor: assessment of length-scale dependency using two analysis methods. Exp Mech. 2021 Sep; 61(7):1069-1080. PMID: 35528779.
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    16. Anderson KD, Ko FC, Fullam S, Virdi AS, Wimmer MA, Sumner DR, Ross RD, Anderson KD, Ko FC, Fullam S, Virdi AS, Wimmer MA, Sumner DR, Ross RD. The relative contribution of bone microarchitecture and matrix composition to implant fixation strength in rats. J Orthop Res. 2022 04; 40(4):862-870. PMID: 34061392; PMCID: PMC8633073.
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    17. Shekhawat VK, Hamilton JL, Pacione CA, Schmid TM, Wimmer MA. A MOVING CONTACT OF ARTICULATION ENHANCES THE BIOSYNTHETIC AND FUNCTIONAL RESPONSES OF ARTICULAR CARTILAGE. Biotribology (Oxf). 2021 Jun; 26. PMID: 33898693.
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    18. Royhman D, Pourzal R, Hall D, Lundberg HJ, Wimmer MA, Jacobs J, Hallab NJ, Mathew MT. Fretting-corrosion in hip taper modular junctions: The influence of topography and pH levels - An in-vitro study. J Mech Behav Biomed Mater. 2021 06; 118:104443. PMID: 33752094.
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    19. Wimmer MA, Radice S, Janssen D, Fischer A. Fretting-corrosion of CoCr-alloys against TiAl6V4: The importance of molybdenum in oxidative biological environments. Wear. 2021 Jul 18; 477. PMID: 34690379.
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    20. Radice S, Impergre A, Fischer A, Wimmer MA. Corrosion resistance of the nickel-free high-nitrogen steel FeCrMnMoN0.9 under simulated inflammatory conditions. J Biomed Mater Res B Appl Biomater. 2021 06; 109(6):902-910. PMID: 33159504.
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    21. Necas D, Sadeck? K, Vrbka M, Galand?kov? A, Wimmer MA, Gallo J, Hartl M. The effect of albumin and ?-globulin on synovial fluid lubrication: Implication for knee joint replacements. J Mech Behav Biomed Mater. 2021 01; 113:104117. PMID: 33065468.
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    22. Yuh C, Laurent MP, Espinosa-Marzal RM, Chubinskaya S, Wimmer MA. Transient stiffening of cartilage during joint articulation: A microindentation study. J Mech Behav Biomed Mater. 2021 01; 113:104113. PMID: 33032010.
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    23. Radice S, Westrick J, Ebinger K, Mathew MT, Wimmer MA. In-vitro studies on cells and tissues in tribocorrosion processes: A systematic scoping review. Biotribology (Oxf). 2020 Dec; 24. PMID: 33015276.
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    24. Shoaib T, Yuh C, Wimmer MA, Schmid TM, Espinosa-Marzal RM. Correction: Nanoscale insight into the degradation mechanisms of the cartilage articulating surface preceding OA. Biomater Sci. 2020 08 11; 8(16):4642. PMID: 32744266.
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    25. Shoaib T, Yuh C, Wimmer MA, Schmid TM, Espinosa-Marzal RM. Nanoscale insight into the degradation mechanisms of the cartilage articulating surface preceding OA. Biomater Sci. 2020 Jul 21; 8(14):3944-3955. PMID: 32555813.
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    26. Mell SP, Wimmer MA, Lundberg HJ. Sensitivity of total knee replacement wear to variability in motion and load input: A parametric finite element analysis study. J Orthop Res. 2020 07; 38(7):1538-1549. PMID: 32458460.
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    27. Goodman SB, Wimmer MA, Ploeg HL. Recent advances in total joint replacement. J Orthop Res. 2020 07; 38(7):1413. PMID: 32410264.
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    28. Knowlton CB, Lundberg HJ, Wimmer MA, Jacobs JJ. Can a gait-dependent model predict wear on retrieved total knee arthroplasty components? Bone Joint J. 2020 Jun; 102-B(6_Supple_A):129-137. PMID: 32475284.
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    29. Pourzal R, Cip J, Rad E, Laurent MP, Berger RA, Jacobs JJ, Wimmer MA. Joint line elevation and tibial slope are associated with increased polyethylene wear in cruciate-retaining total knee replacement. J Orthop Res. 2020 07; 38(7):1596-1606. PMID: 32374428.
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    30. Ngai V, Kunze J, Cip J, Laurent MP, Jacobs JJ, Wimmer MA. Backside wear of tibial polyethylene components is affected by gait pattern: A knee simulator study using rare earth tracer technology. J Orthop Res. 2020 07; 38(7):1607-1616. PMID: 32410286.
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    31. Fullam S, He J, Scholl CS, Schmid TM, Wimmer MA. Competitive Binding of Bilirubin and Fatty Acid on Serum Albumin Affects Wear of UHMWPE. Lubricants. 2020 May; 8(5). PMID: 32655922.
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    32. Balachandran S, Zachariah Z, Fischer A, Mayweg D, Wimmer MA, Raabe D, Herbig M. Atomic Scale Origin of Metal Ion Release from Hip Implant Taper Junctions. Adv Sci (Weinh). 2020 Mar; 7(5):1903008. PMID: 32154080.
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    33. Wimmer MA, Pacione C, Yuh C, Chan YM, Kunze J, Laurent MP, Chubinskaya S. Articulation of an alumina-zirconia composite ceramic against living cartilage - An in vitro wear test. J Mech Behav Biomed Mater. 2020 03; 103:103531. PMID: 31756562.
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    34. Radice S, Liu S, Pourzal R, Laurent MP, Wimmer MA. Effects of bovine serum albumin and hyaluronic acid on the electrochemical response of a CoCrMo alloy to cathodic and anodic excursions. J Bio Tribocorros. 2019 Dec; 5(4). PMID: 31828005.
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    35. Dawe RJ, Yu L, Leurgans SE, Truty T, Curran T, Hausdorff JM, Wimmer MA, Block JA, Bennett DA, Buchman AS. Expanding instrumented gait testing in the community setting: A portable, depth-sensing camera captures joint motion in older adults. PLoS One. 2019; 14(5):e0215995. PMID: 31091267.
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    36. Radice S, Yao J, Babauta J, Laurent MP, Wimmer MA. The effect of hyaluronic acid on the corrosion of an orthopedic CoCrMo-alloy in simulated inflammatory conditions. Materialia (Oxf). 2019 Jun; 6. PMID: 31183460.
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    37. He J, Lippmann K, Shakoor N, Ferrigno C, Wimmer MA. Unsupervised gait retraining using a wireless pressure-detecting shoe insole. Gait Posture. 2019 05; 70:408-413. PMID: 30986588.
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    38. Radice S, Holcomb T, Pourzal R, Hallab NJ, Laurent MP, Wimmer MA. Investigation of CoCrMo material loss in a novel bio-tribometer designed to study direct cell reaction to wear and corrosion products. Biotribology (Oxf). 2019 Jun; 18. PMID: 30984811.
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    39. Mell SP, Wimmer MA, Lundberg HJ. The choice of the femoral center of rotation affects material loss in total knee replacement wear testing - A parametric finite element study of ISO 14243-3. J Biomech. 2019 May 09; 88:104-112. PMID: 30940359.
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    40. Schipper ON, Haddad SL, Fullam S, Pourzal R, Wimmer MA. Wear Characteristics of Conventional Ultrahigh-Molecular-Weight Polyethylene Versus Highly Cross-Linked Polyethylene in Total Ankle Arthroplasty. Foot Ankle Int. 2018 11; 39(11):1335-1344. PMID: 30019605.
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    41. Simon JC, Della Valle CJ, Wimmer MA. Level and Downhill Walking to Assess Implant Functionality in Bicruciate- and Posterior Cruciate-Retaining Total Knee Arthroplasty. J Arthroplasty. 2018 09; 33(9):2884-2889. PMID: 29858100.
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    42. Farkas GJ, Schlink BR, Fogg LF, Foucher KC, Wimmer MA, Shakoor N. Gait asymmetries in unilateral symptomatic hip osteoarthritis and their association with radiographic severity and pain. Hip Int. 2019 Mar; 29(2):209-214. PMID: 29734841.
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    43. Mell SP, Fullam S, Wimmer MA, Lundberg HJ. Finite element evaluation of the newest ISO testing standard for polyethylene total knee replacement liners. Proc Inst Mech Eng H. 2018 Jun; 232(6):545-552. PMID: 29658386.
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    44. Veselack T, Aldebert G, Trunfio-Sfarghiu AM, Schmid TM, Laurent MP, Wimmer MA. Phospholipid Vesicles in Media for Tribological Studies against Live Cartilage. Lubricants. 2018; 6(1). PMID: 29527359.
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    45. Royhman D, Patel M, Jacobs JJ, Wimmer MA, Hallab NJ, Mathew MT. In vitro simulation of fretting-corrosion in hip implant modular junctions: The influence of pH. Med Eng Phys. 2018 02; 52:1-9. PMID: 29290499.
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    46. Ardestani MM, Malloy P, Nam D, Rosenberg AG, Wimmer MA. TKA patients with unsatisfying knee function show changes in neuromotor synergy pattern but not joint biomechanics. J Electromyogr Kinesiol. 2017 Dec; 37:90-100. PMID: 28987921.
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    47. Dwivedi Y, Laurent MP, Sarvepalli S, Schmid TM, Wimmer MA. Albumin Protein Cleavage Affects the Wear and Friction of Ultra-High Molecular Weight Polyethylene. Lubricants. 2017 Sep; 5(3). PMID: 28936362.
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    48. Espallargas N, Fischer A, Mu?oz AI, Mischler S, Wimmer MA. In-situ Generated Tribomaterial in Metal/Metal Contacts: current understanding and future implications for implants. Biotribology (Oxf). 2017 Jun; 10:42-50. PMID: 28808674.
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    49. Ardestani MM, Amen?bar Edwards PP, Wimmer MA. Prediction of Polyethylene Wear Rates from Gait Biomechanics and Implant Positioning in Total Hip Replacement. Clin Orthop Relat Res. 2017 Aug; 475(8):2027-2042. PMID: 28255945.
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    50. Freed RD, Simon JC, Knowlton CB, Orozco Villase?or DA, Wimmer MA, Lundberg HJ. Are Instrumented Knee Forces Representative of a Larger Population of Cruciate-Retaining Total Knee Arthroplasties? J Arthroplasty. 2017 07; 32(7):2268-2273. PMID: 28262455.
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    51. Gitelis SL, Bodker A, Laurent MP, Kirk SS, Filardo G, Meyer MA, Hakimiyan AA, Rappoport L, Wimmer MA, Cole BJ, Chubinskaya S. The Effect of Surgical Insertion and Proinflammatory Cytokines on Osteochondral Allograft Survival and Metabolism. Cartilage. 2018 07; 9(3):284-292. PMID: 28418278.
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    52. Chalmers PN, Wimmer MA, Verma NN, Cole BJ, Romeo AA, Cvetanovich GL, Pearl ML. The Relationship Between Pitching Mechanics and Injury: A Review of Current Concepts. Sports Health. 2017 May/Jun; 9(3):216-221. PMID: 28107113.
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    53. Trevino RL, Pacione CA, Malfait AM, Chubinskaya S, Wimmer MA. Development of a Cartilage Shear-Damage Model to Investigate the Impact of Surface Injury on Chondrocytes and Extracellular Matrix Wear. Cartilage. 2017 Oct; 8(4):444-455. PMID: 28934882.
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    54. Trevino RL, Stoia J, Laurent MP, Pacione CA, Chubinskaya S, Wimmer MA. ESTABLISHING A LIVE CARTILAGE-ON-CARTILAGE INTERFACE FOR TRIBOLOGICAL TESTING. Biotribology (Oxf). 2017 Mar; 9:1-11. PMID: 29242820.
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    55. Shekhawat VK, Schmid TM, Pennekamp PH, Pacione CA, Chubinskaya S, Wimmer MA. Implications of trauma and subsequent articulation on the release of Proteoglycan-4 and tissue response in adult human ankle cartilage. J Orthop Res. 2017 03; 35(3):667-676. PMID: 27551813.
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    56. Orozco Villase?or DA, Wimmer MA. Wear Scar Similarities between Retrieved and Simulator-Tested Polyethylene TKR Components: An Artificial Neural Network Approach. Biomed Res Int. 2016; 2016:2071945. PMID: 27597955.
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    57. Garn H, Kohn B, Dittrich K, Wiesmeyr C, Kloesch G, Stepansky R, Wimmer M, Ipsiroglu O, Grossegger D, Kemethofer M, Seidel S. 3D detection of periodic limb movements in sleep. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:427-430. PMID: 28268364.
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    58. Knowlton CB, Bhutani P, Wimmer MA. Relationship of surface damage appearance and volumetric wear in retrieved TKR polyethylene liners. J Biomed Mater Res B Appl Biomater. 2017 10; 105(7):2053-2059. PMID: 27401236.
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    59. Royhman D, Patel M, Runa MJ, Wimmer MA, Jacobs JJ, Hallab NJ, Mathew MT. Fretting-corrosion behavior in hip implant modular junctions: The influence of friction energy and pH variation. J Mech Behav Biomed Mater. 2016 09; 62:570-587. PMID: 27310572.
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    60. Ardestani MM, Wimmer MA. Can a linear combination of gait principal component vectors identify hip OA stages? J Biomech. 2016 07 05; 49(10):2023-2030. PMID: 27255606.
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    61. Ferrigno C, Wimmer MA, Trombley RM, Lundberg HJ, Shakoor N, Thorp LE. A reduction in the knee adduction moment with medial thrust gait is associated with a medial shift in center of plantar pressure. Med Eng Phys. 2016 07; 38(7):615-621. PMID: 27158051.
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    62. Kraeutler MJ, Kaenkumchorn T, Pascual-Garrido C, Wimmer MA, Chubinskaya S. Peculiarities in Ankle Cartilage. Cartilage. 2017 Jan; 8(1):12-18. PMID: 27994716.
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    63. Frank RM, Lundberg H, Wimmer MA, Forsythe B, Bach BR, Verma NN, Cole BJ. Hamstring Activity in the Anterior Cruciate Ligament Injured Patient: Injury Implications and Comparison With Quadriceps Activity. Arthroscopy. 2016 08; 32(8):1651-9. PMID: 27067475.
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    64. Pourzal R, Knowlton CB, Hall DJ, Laurent MP, Urban RM, Wimmer MA. How Does Wear Rate Compare in Well-functioning Total Hip and Knee Replacements? A Postmortem Polyethylene Liner Study. Clin Orthop Relat Res. 2016 Aug; 474(8):1867-75. PMID: 26891896.
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    65. Ardestani MM, Ferrigno C, Moazen M, Wimmer MA. From normal to fast walking: Impact of cadence and stride length on lower extremity joint moments. Gait Posture. 2016 05; 46:118-25. PMID: 27131188.
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    66. Ferrigno C, Stoller IS, Shakoor N, Thorp LE, Wimmer MA. The Feasibility of Using Augmented Auditory Feedback From a Pressure Detecting Insole to Reduce the Knee Adduction Moment: A Proof of Concept Study. J Biomech Eng. 2016 Feb; 138(2):021014. PMID: 26632644.
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    67. Lundberg HJ, Rojas IL, Foucher KC, Wimmer MA. Comparison of Antagonist Muscle Activity During Walking Between Total Knee Replacement and Control Subjects Using Unnormalized Electromyography. J Arthroplasty. 2016 06; 31(6):1331-1339. PMID: 26763897.
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    68. Sandy JD, Chan DD, Trevino RL, Wimmer MA, Plaas A. Human genome-wide expression analysis reorients the study of inflammatory mediators and biomechanics in osteoarthritis. Osteoarthritis Cartilage. 2015 Nov; 23(11):1939-45. PMID: 26521740.
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    69. Royhman D, Patel M, Runa MJ, Jacobs JJ, Hallab NJ, Wimmer MA, Mathew MT. Fretting-corrosion in Hip Implant Modular Junctions: New Experimental Set-up and Initial Outcome. Tribol Int. 2015 Nov 01; 91:235-245. PMID: 26405372.
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    70. Chalmers PN, Cvetanovich GL, Kupfer N, Wimmer MA, Verma NN, Cole BJ, Romeo AA, Nicholson GP. The champagne toast position isolates the supraspinatus better than the Jobe test: an electromyographic study of shoulder physical examination tests. J Shoulder Elbow Surg. 2016 Feb; 25(2):322-9. PMID: 26443105.
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    71. Wimmer MA, Nechtow W, Schwenke T, Moisio KC. Knee Flexion and Daily Activities in Patients following Total Knee Replacement: A Comparison with ISO Standard 14243. Biomed Res Int. 2015; 2015:157541. PMID: 26347875.
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    72. Wimmer MA, Laurent MP, Mathew MT, Nagelli C, Liao Y, Marks LD, Jacobs JJ, Fischer A. The effect of contact load on CoCrMo wear and the formation and retention of tribofilms. Wear. 2015 May-Jun; 332-333:643-649. PMID: 26085697.
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    73. Sgroi T, Chalmers PN, Riff AJ, Lesniak M, Sayegh ET, Wimmer MA, Verma NN, Cole BJ, Romeo AA. Predictors of throwing velocity in youth and adolescent pitchers. J Shoulder Elbow Surg. 2015 Sep; 24(9):1339-45. PMID: 25842029.
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    74. Grupp TM, Utzschneider S, Wimmer MA. Biotribology in knee arthroplasty. Biomed Res Int. 2015; 2015:618974. PMID: 25883967.
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    75. Ngai V, Wimmer MA. Variability of TKR knee kinematics and relationship with gait kinetics: implications for total knee wear. Biomed Res Int. 2015; 2015:284513. PMID: 25866770.
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    76. Shakoor N, Foucher KC, Wimmer MA, Mikolaitis-Preuss RA, Fogg LF, Block JA. Asymmetries and relationships between dynamic loading, muscle strength, and proprioceptive acuity at the knees in symptomatic unilateral hip osteoarthritis. Arthritis Res Ther. 2014 Dec 14; 16(6):455. PMID: 25496937.
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    77. Brobeil A, Viard M, Petri MK, Steger K, Tag C, Wimmer M. Memory and PTPIP51--a new protein in hippocampus and cerebellum. Mol Cell Neurosci. 2015 Jan; 64:61-73. PMID: 25496818.
      Citations:    
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    116. Liao Y, Pourzal R, Wimmer MA, Jacobs JJ, Fischer A, Marks LD. Graphitic tribological layers in metal-on-metal hip replacements. Science. 2011 Dec 23; 334(6063):1687-90. PMID: 22194573.
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    117. Shakoor N, Dua A, Thorp LE, Mikolaitis RA, Wimmer MA, Foucher KC, Fogg LF, Block JA. Asymmetric loading and bone mineral density at the asymptomatic knees of patients with unilateral hip osteoarthritis. Arthritis Rheum. 2011 Dec; 63(12):3853-8. PMID: 22127702.
      Citations:    
    118. Petri MK, Koch P, Stenzinger A, Kuchelmeister K, Nestler U, Paradowska A, Steger K, Brobeil A, Viard M, Wimmer M. PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3? and PTP1B in situ. Histol Histopathol. 2011 12; 26(12):1531-43. PMID: 21972092.
      Citations:    
    119. Abey S, Mathew MT, Lee DJ, Knoernschild KL, Wimmer MA, Sukotjo C. Electrochemical behavior of titanium in artificial saliva: influence of pH. J Oral Implantol. 2014 Feb; 40(1):3-10. PMID: 22103963.
      Citations:    
    120. Mathew MT, Bar?o VA, Yuan JC, Assun??o WG, Sukotjo C, Wimmer MA. What is the role of lipopolysaccharide on the tribocorrosive behavior of titanium? J Mech Behav Biomed Mater. 2012 Apr; 8:71-85. PMID: 22402155.
      Citations:    
    121. Foucher KC, Wimmer MA. Contralateral hip and knee gait biomechanics are unchanged by total hip replacement for unilateral hip osteoarthritis. Gait Posture. 2012 Jan; 35(1):61-5. PMID: 21903396.
      Citations:    
    122. Bar?o VA, Mathew MT, Assun??o WG, Yuan JC, Wimmer MA, Sukotjo C. Stability of cp-Ti and Ti-6Al-4V alloy for dental implants as a function of saliva pH - an electrochemical study. Clin Oral Implants Res. 2012 Sep; 23(9):1055-62. PMID: 22092540.
      Citations:    
    123. Gallardo LA, Carpentieri I, Laurent MP, Costa L, Wimmer MA. Europium stearate additives delay oxidation of UHMWPE for orthopaedic applications: a pilot study. Clin Orthop Relat Res. 2011 Aug; 469(8):2294-301. PMID: 21153455.
      Citations:    
    124. Mathew MT, Runa MJ, Laurent M, Jacobs JJ, Rocha LA, Wimmer MA. Tribocorrosion behavior of CoCrMo alloy for hip prosthesis as a function of loads: a comparison between two testing systems. Wear. 2011 Jul 29; 271(9-10):1210-1219. PMID: 21921971.
      Citations:    
    125. Weber O, Pagenstert G, Wirtz DC, Burger C, Wimmer M, Pennekamp PH, Gravius S, M?ller M. [Refixation of distal biceps tendon rupture using 2 anchor sutures - sports ability after 1 year follow-up and operative technique]. Sportverletz Sportschaden. 2011 Jun; 25(2):97-102. PMID: 21611913.
      Citations:    
    126. Catelas I, Wimmer MA. New insights into wear and biological effects of metal-on-metal bearings. J Bone Joint Surg Am. 2011 May; 93 Suppl 2:76-83. PMID: 21543694.
      Citations:    
    127. Laurent MP, Pourzal R, Fischer A, Bertin KC, Jacobs JJ, Wimmer MA. In vivo wear of a squeaky alumina-on-alumina hip prosthesis: a case report. J Bone Joint Surg Am. 2011 Apr 06; 93(7):e27. PMID: 21471407.
      Citations:    
    128. Bar?o VA, Mathew MT, Assun??o WG, Yuan JC, Wimmer MA, Sukotjo C. The role of lipopolysaccharide on the electrochemical behavior of titanium. J Dent Res. 2011 May; 90(5):613-8. PMID: 21335537.
      Citations:    
    129. Catelas I, Wimmer MA, Utzschneider S. Polyethylene and metal wear particles: characteristics and biological effects. Semin Immunopathol. 2011 May; 33(3):257-71. PMID: 21267569.
      Citations:    
    130. Gallardo LA, Knowlton CB, Kunze J, Jacobs JJ, Wimmer MA, Laurent MP. Effect of europium(II) stearate on the mechanical properties and the oxidation resistance of UHMWPE. J Mech Behav Biomed Mater. 2011 Jul; 4(5):821-6. PMID: 21565729.
      Citations:    
    131. Foucher KC, Wimmer MA, Moisio KC, Hildebrand M, Berli MC, Walker MR, Berger RA, Galante JO. Time course and extent of functional recovery during the first postoperative year after minimally invasive total hip arthroplasty with two different surgical approaches--a randomized controlled trial. J Biomech. 2011 Feb 03; 44(3):372-8. PMID: 21075378.
      Citations:    
    132. Takigawa T, Espinoza Or?as AA, An HS, Gohgi S, Udayakumar RK, Sugisaki K, Natarajan RN, Wimmer MA, Inoue N. Spinal kinematics and facet load transmission after total disc replacement. Spine (Phila Pa 1976). 2010 Oct 15; 35(22):E1160-6. PMID: 20881657.
      Citations:    
    133. Balash P, Kang RW, Schwenke T, Cole BJ, Wimmer MA. Osteochondral Tissue Cell Viability Is Affected by Total Impulse during Impaction Grafting. Cartilage. 2010 Oct; 1(4):270-5. PMID: 26069558.
      Citations:    
    134. Foucher KC, Thorp LE, Orozco D, Hildebrand M, Wimmer MA. Differences in preferred walking speeds in a gait laboratory compared with the real world after total hip replacement. Arch Phys Med Rehabil. 2010 Sep; 91(9):1390-5. PMID: 20801257.
      Citations:    
    135. Bajaj S, Shoemaker T, Hakimiyan AA, Rappoport L, Pascual-Garrido C, Oegema TR, Wimmer MA, Chubinskaya S. Protective effect of P188 in the model of acute trauma to human ankle cartilage: the mechanism of action. J Orthop Trauma. 2010 Sep; 24(9):571-6. PMID: 20736797.
      Citations:    
    136. G?rke UJ, G?nther H, Nagel T, Wimmer MA. A large strain material model for soft tissues with functionally graded properties. J Biomech Eng. 2010 Jul; 132(7):074502. PMID: 20590295.
      Citations:    
    137. Shakoor N, Sengupta M, Foucher KC, Wimmer MA, Fogg LF, Block JA. Effects of common footwear on joint loading in osteoarthritis of the knee. Arthritis Care Res (Hoboken). 2010 Jul; 62(7):917-23. PMID: 20191571.
      Citations:    
    138. Thorp LE, Wimmer MA, Foucher KC, Sumner DR, Shakoor N, Block JA. The biomechanical effects of focused muscle training on medial knee loads in OA of the knee: a pilot, proof of concept study. J Musculoskelet Neuronal Interact. 2010 Jun; 10(2):166-73. PMID: 20516634.
      Citations:    
    139. Wimmer MA, Fischer A, B?scher R, Pourzal R, Sprecher C, Hauert R, Jacobs JJ. Wear mechanisms in metal-on-metal bearings: the importance of tribochemical reaction layers. J Orthop Res. 2010 Apr; 28(4):436-43. PMID: 19877285.
      Citations:    
    140. Koch P, Viard M, Stenzinger A, Brobeil A, Tag C, Steger K, Wimmer M. Expression profile of PTPIP51 in mouse brain. J Comp Neurol. 2009 Dec 20; 517(6):892-905. PMID: 19844996.
      Citations:    
    141. Foucher KC, Hurwitz DE, Wimmer MA. Relative importance of gait vs. joint positioning on hip contact forces after total hip replacement. J Orthop Res. 2009 Dec; 27(12):1576-82. PMID: 19514072.
      Citations:    
    142. Kang RW, Friel NA, Williams JM, Cole BJ, Wimmer MA. Effect of impaction sequence on osteochondral graft damage: the role of repeated and varying loads. Am J Sports Med. 2010 Jan; 38(1):105-13. PMID: 19915099.
      Citations:    
    143. Ngai V, Schwenke T, Wimmer MA. In-vivo kinematics of knee prostheses patients during level walking compared with the ISO force-controlled simulator standard. Proc Inst Mech Eng H. 2009 Oct; 223(7):889-96. PMID: 19908427.
      Citations:    
    144. Ngai V, Wimmer MA. Kinematic evaluation of cruciate-retaining total knee replacement patients during level walking: a comparison with the displacement-controlled ISO standard. J Biomech. 2009 Oct 16; 42(14):2363-8. PMID: 19651410.
      Citations:    
    145. Kaddick C, Catelas I, Pennekamp PH, Wimmer MA. [Implant wear and aseptic loosening. An overview]. Orthopade. 2009 Aug; 38(8):690-7. PMID: 19657620.
      Citations:    
    146. Galetz MC, Uth T, Wimmer MA, Adam P, Glatzel U. Determination of the temperature rise within UHMWPE tibial components during tribological loading. Acta Biomater. 2010 Feb; 6(2):552-62. PMID: 19539061.
      Citations:    
    147. Braunstein V, Sprecher CM, Wimmer MA, Milz S, Taeger G. Influence of head size on the development of metallic wear and on the characteristics of carbon layers in metal-on-metal hip joints. Acta Orthop. 2009 Jun; 80(3):283-90. PMID: 19421914.
      Citations:    
    148. Shekhawat VK, Laurent MP, Muehleman C, Wimmer MA. Surface topography of viable articular cartilage measured with scanning white light interferometry. Osteoarthritis Cartilage. 2009 Sep; 17(9):1197-203. PMID: 19349041.
      Citations:    
    149. Pascual Garrido C, Hakimiyan AA, Rappoport L, Oegema TR, Wimmer MA, Chubinskaya S. Anti-apoptotic treatments prevent cartilage degradation after acute trauma to human ankle cartilage. Osteoarthritis Cartilage. 2009 Sep; 17(9):1244-51. PMID: 19332178.
      Citations:    
    150. Jacobs JJ, Urban RM, Hallab NJ, Skipor AK, Fischer A, Wimmer MA. Metal-on-metal bearing surfaces. J Am Acad Orthop Surg. 2009 Feb; 17(2):69-76. PMID: 19202120.
      Citations:    
    151. Rojas IL, Provencher MT, Bhatia S, Foucher KC, Bach BR, Romeo AA, Wimmer MA, Verma NN. Biceps activity during windmill softball pitching: injury implications and comparison with overhand throwing. Am J Sports Med. 2009 Mar; 37(3):558-65. PMID: 19174551.
      Citations:    
    152. Lundberg HJ, Foucher KC, Wimmer MA. A parametric approach to numerical modeling of TKR contact forces. J Biomech. 2009 Mar 11; 42(4):541-5. PMID: 19155015.
      Citations:    
    153. Wimmer MA, Alini M, Grad S. The effect of sliding velocity on chondrocytes activity in 3D scaffolds. J Biomech. 2009 Mar 11; 42(4):424-9. PMID: 19152917.
      Citations:    
    154. Koch P, Stenzinger A, Viard M, M?rker D, Mayser P, Nilles M, Schreiner D, Steger K, Wimmer M. The novel protein PTPIP51 is expressed in human keratinocyte carcinomas and their surrounding stroma. J Cell Mol Med. 2008 Oct; 12(5B):2083-95. PMID: 19012732.
      Citations:    
    155. Foucher KC, Hurwitz DE, Wimmer MA. Do gait adaptations during stair climbing result in changes in implant forces in subjects with total hip replacements compared to normal subjects? Clin Biomech (Bristol, Avon). 2008 Jul; 23(6):754-61. PMID: 18433952.
      Citations:    
    156. Salineros MJ, Crowninshield RD, Laurent M, Wimmer MA, Jacobs JJ. Analysis of retrieved acetabular components of three polyethylene types. Clin Orthop Relat Res. 2007 Dec; 465:140-9. PMID: 17632415.
      Citations:    
    157. Wimmer MA, Schmid TM, Jacobs JJ. Tribology: a portal to understand joint failure? Arthritis Rheum. 2007 Nov; 56(11):3511-3. PMID: 17968920.
      Citations:    
    158. Thorp LE, Sumner DR, Wimmer MA, Block JA. Relationship between pain and medial knee joint loading in mild radiographic knee osteoarthritis. Arthritis Rheum. 2007 Oct 15; 57(7):1254-60. PMID: 17907211.
      Citations:    
    159. Foucher KC, Hurwitz DE, Wimmer MA. Preoperative gait adaptations persist one year after surgery in clinically well-functioning total hip replacement patients. J Biomech. 2007; 40(15):3432-7. PMID: 17644101.
      Citations:    
    160. Pennekamp PH, Wimmer MA, Eschbach L, Burian B, Koch P, Kraft CN. Microvasculatory reaction of skeletal muscle to Ti-15Mo in comparison to well-established titanium alloys. J Mater Sci Mater Med. 2007 Oct; 18(10):2053-60. PMID: 17558479.
      Citations:    
    161. Pylawka TK, Wimmer M, Cole BJ, Virdi AS, Williams JM. Impaction affects cell viability in osteochondral tissues during transplantation. J Knee Surg. 2007 Apr; 20(2):105-10. PMID: 17486901.
      Citations:    
    162. Thorp LE, Sumner DR, Block JA, Moisio KC, Shott S, Wimmer MA. Knee joint loading differs in individuals with mild compared with moderate medial knee osteoarthritis. Arthritis Rheum. 2006 Dec; 54(12):3842-9. PMID: 17133592.
      Citations:    
    163. Grad S, Gogolewski S, Alini M, Wimmer MA. Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds. Tissue Eng. 2006 Nov; 12(11):3171-9. PMID: 17518631.
      Citations:    
    164. Honl M, Schwieger K, Salineros M, Jacobs J, Morlock M, Wimmer M. Orientation of the acetabular component. A comparison of five navigation systems with conventional surgical technique. J Bone Joint Surg Br. 2006 Oct; 88(10):1401-5. PMID: 17012436.
      Citations:    
    165. Sporer SM, DellaValle C, Jacobs J, Wimmer M. A case of disassociation of a modular femoral neck trunion after total hip arthroplasty. J Arthroplasty. 2006 Sep; 21(6):918-21. PMID: 16950051.
      Citations:    
    166. Burian B, Wimmer MA, Kunze J, Sprecher CM, Pennekamp PH, von Engelhardt LV, Diedrich O, Kraft CN. [Systemic spread of wear debris--an in-vivo study]. Z Orthop Ihre Grenzgeb. 2006 Sep-Oct; 144(5):539-44. PMID: 16991074.
      Citations:    
    167. Crowninshield RD, Wimmer MA, Jacobs JJ, Rosenberg AG. Clinical performance of contemporary tibial polyethylene components. J Arthroplasty. 2006 Aug; 21(5):754-61. PMID: 16877165.
      Citations:    
    168. Thorp LE, Wimmer MA, Block JA, Moisio KC, Shott S, Goker B, Sumner DR. Bone mineral density in the proximal tibia varies as a function of static alignment and knee adduction angular momentum in individuals with medial knee osteoarthritis. Bone. 2006 Nov; 39(5):1116-1122. PMID: 16782419.
      Citations:    
    169. Jacobs JJ, Hallab NJ, Urban RM, Wimmer MA. Wear particles. J Bone Joint Surg Am. 2006 Apr; 88 Suppl 2:99-102. PMID: 16595453.
      Citations:    
    170. Pennekamp PH, Gessmann J, Diedrich O, Burian B, Wimmer MA, Frauchiger VM, Kraft CN. Short-term microvascular response of striated muscle to cp-Ti, Ti-6Al-4V, and Ti-6Al-7Nb. J Orthop Res. 2006 Mar; 24(3):531-40. PMID: 16463365.
      Citations:    
    171. Wimmer MA, Nassutt R, Sprecher C, Loos J, T?ger G, Fischer A. Investigation on stick phenomena in metal-on-metal hip joints after resting periods. Proc Inst Mech Eng H. 2006 Feb; 220(2):219-27. PMID: 16669389.
      Citations:    
    172. Grad S, Lee CR, Wimmer MA, Alini M. Chondrocyte gene expression under applied surface motion. Biorheology. 2006; 43(3,4):259-69. PMID: 16912399.
      Citations:    
    173. Honl M, Schwieger K, Gauck CH, Lampe F, Morlock MM, Wimmer MA, Hille E. [Comparison of total hip replacements cup orientation and position. Navigation vs. conventional manual implantation of hip prostheses]. Orthopade. 2005 Nov; 34(11):1131-6. PMID: 16235087.
      Citations:    
    174. Schwenke T, Kaddick C, Schneider E, Wimmer MA. Fluid composition impacts standardized testing protocols in ultrahigh molecular weight polyethylene knee wear testing. Proc Inst Mech Eng H. 2005 Nov; 219(6):457-64. PMID: 16312105.
      Citations:    
    175. Kraft CN, Burian B, Diedrich O, Gessmann J, Wimmer MA, Pennekamp PH. Microvascular response of striated muscle to common arthroplasty-alloys: A comparative in vivo study with CoCrMo, Ti-6Al-4V, and Ti-6Al-7Nb. J Biomed Mater Res A. 2005 Oct 01; 75(1):31-40. PMID: 16078208.
      Citations:    
    176. Rastogi S, Kurelec L, Lippits D, Cuijpers J, Wimmer M, Lemstra PJ. Novel route to fatigue-resistant fully sintered ultrahigh molecular weight polyethylene for knee prosthesis. Biomacromolecules. 2005 Mar-Apr; 6(2):942-7. PMID: 15762663.
      Citations:    
    177. B?scher R, T?ger G, Dudzinski W, Gleising B, Wimmer MA, Fischer A. Subsurface microstructure of metal-on-metal hip joints and its relationship to wear particle generation. J Biomed Mater Res B Appl Biomater. 2005 Jan 15; 72(1):206-14. PMID: 15497166.
      Citations:    
    178. Grad S, Lee CR, Gorna K, Gogolewski S, Wimmer MA, Alini M. Surface motion upregulates superficial zone protein and hyaluronan production in chondrocyte-seeded three-dimensional scaffolds. Tissue Eng. 2005 Jan-Feb; 11(1-2):249-56. PMID: 15738679.
      Citations:    
    179. Wimmer MA, Grad S, Kaup T, H?nni M, Schneider E, Gogolewski S, Alini M. Tribology approach to the engineering and study of articular cartilage. Tissue Eng. 2004 Sep-Oct; 10(9-10):1436-45. PMID: 15588403.
      Citations:    
    180. von Knoch M, Sprecher C, Barden B, Saxler G, L?er F, Wimmer M. [Size and shape of commercially available polyethylene particles for in-vitro and in-vivo-experiments]. Z Orthop Ihre Grenzgeb. 2004 May-Jun; 142(3):366-70. PMID: 15250012.
      Citations:    
    181. Nassutt R, Wimmer MA, Schneider E, Morlock MM. The influence of resting periods on friction in the artificial hip. Clin Orthop Relat Res. 2003 Feb; (407):127-38. PMID: 12567139.
      Citations:    
    182. Kraft CN, Diedrich O, Burian B, Schmitt O, Wimmer MA. Microvascular response of striated muscle to metal debris. A comparative in vivo study with titanium and stainless steel. J Bone Joint Surg Br. 2003 Jan; 85(1):133-41. PMID: 12585592.
      Citations:    
    183. Kraft CN, Burian B, Diedrich O, Wimmer MA. Implications of orthopedic fretting corrosion particles on skeletal muscle microcirculation. J Mater Sci Mater Med. 2001 Oct-Dec; 12(10-12):1057-62. PMID: 15348365.
      Citations:    
    184. Kaddick C, Wimmer MA. Hip simulator wear testing according to the newly introduced standard ISO 14242. Proc Inst Mech Eng H. 2001; 215(5):429-42. PMID: 11726043.
      Citations:    
    185. Kunze J, Koelling S, Reich M, Wimmer MA. Use of ultrasonic nebulizer with desolvator membrane for the determination of titanium and zirconium in human serum by means of inductively coupled plasma--mass spectroscopy. Fresenius J Anal Chem. 2000 Jan; 366(2):165-6. PMID: 11225920.
      Citations:    
    186. Lampe F, Grischke M, Wimmer MA, Nassutt R, Klages CP, Hille E, Schneider E. [Effect of surface hardness of the femur head prosthesis on abrasive wear forces in pairing with polyethylene for artificial hip joints]. Biomed Tech (Berl). 1998 Mar; 43(3):58-62. PMID: 9556933.
      Citations:    
    187. Wimmer MA, Andriacchi TP, Natarajan RN, Loos J, Karlhuber M, Petermann J, Schneider E, Rosenberg AG. A striated pattern of wear in ultrahigh-molecular-weight polyethylene components of Miller-Galante total knee arthroplasty. J Arthroplasty. 1998 Jan; 13(1):8-16. PMID: 9493532.
      Citations:    
    188. G?lzh?user G, Wimmer MA, Berzins A, Sumner DR, Scheuvens BJ, Schneider E. [Development and validation of a method for wear measurement of polyethylene hip acetabulum with metal backing using roentgen images]. Biomed Tech (Berl). 1998; 43 Suppl:66-7. PMID: 9859260.
      Citations:    
    189. Wimmer MA, Andriacchi TP. Tractive forces during rolling motion of the knee: implications for wear in total knee replacement. J Biomech. 1997 Feb; 30(2):131-7. PMID: 9001933.
      Citations:    
    190. Willmann G, Richter H, Wimmer M. [Rotational bending test of hydroxylapatite plasma-coated models of TiAl6V4]. Biomed Tech (Berl). 1993 Jan-Feb; 38(1-2):14-6. PMID: 8461442.
      Citations:    
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