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Alejandro Espinoza-Orias

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentOrthopedic Surgery
Address1611 W. Harrison St.
Chicago IL 60612
ORCID ORCID Icon0000-0002-3792-515X Additional info
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    Alejandro A. Espinoza Orias, PhD, received a licentiate degree in mechanical engineering degree from the Universidad Mayor de San Andres (La Paz, Bolivia) in addition to master’s and doctoral degrees in aerospace and mechanical engineering at the University of Notre Dame (Notre Dame, Indiana). He later completed a postdoctoral fellowship in spine biomechanics at the McKay orthopedic research laboratory at the University of Pennsylvania (Philadelphia, Pennsylvania, USA). He is an assistant professor in the Department of Orthopedic Surgery at Rush University Medical Center (Chicago). His research interests include joint biomechanics, the study of structure-function relationships in orthopedic materials and tissues and applications of 3-D printing in orthopedics.

    Espinoza Orias is an active member of the Orthopaedic Research Society, American Society of Mechanical Engineers, American Society for Testing and Materials International, and Sigma Xi, the Scientific Research Society, He conducts peer review on many orthopedic and biomechanics journals and is on the editorial board of PLoS One.

    My ORCID is 0000-0002-3792-515X.
    My Scopus ID is 57188703592.
    My NIH COMMONS name is AESPINOZA

    Education
    Postdoctoral fellowship, McKay Orthopaedic Research Lab, Perelman School of Medicine, University of Pennsylvania, 2007
    PhD, aerospace and mechanical engineering, University of Notre Dame, 2005
    MSc, mechanical engineering, University of Notre Dame, 2003
    BSc (Licentiate), mechanical engineering, Universidad Mayor de San Andres, Bolivia, 1999

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aboushaala K, Chee AV, Toro SJ, Vucicevic R, Yuh C, Dourdourekas J, Patel IK, Espinoza-Orias A, Oh C, Al-Harthi L, Karppinen J, Goldberg EJ, Phillips FM, Colman M, Williams FMK, Borgia JA, Green S, Forsyth C, An HS, Samartzis D. Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis. Eur Spine J. 2024 Mar 07. PMID: 38451373.
      Citations:    
    2. Mallow GM, Zepeda D, Kuzel TG, Barajas JN, Aboushaala K, Nolte MT, Espinoza-Orias A, Oh C, Colman M, Kogan M, Phillips FM, An HS, Samartzis D. ISSLS PRIZE in Clinical Science 2022: Epidemiology, risk factors and clinical impact of juvenile Modic changes in paediatric patients with low back pain. Eur Spine J. 2022 05; 31(5):1069-1079. PMID: 35129673.
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    3. Zavras AG, Dandu N, Espinoza-Orias AA, Singh K, An HS, Inoue N, Colman MW. Computed Tomography Osteoabsorptiometry Evaluation of Cervical Endplate Subchondral Bone Mineral Density. Global Spine J. 2023 Sep; 13(7):1803-1811. PMID: 34736350.
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    4. Wong AYL, Harada G, Lee R, Gandhi SD, Dziedzic A, Espinoza-Orias A, Parnianpour M, Louie PK, Basques B, An HS, Samartzis D. Preoperative paraspinal neck muscle characteristics predict early onset adjacent segment degeneration in anterior cervical fusion patients: A machine-learning modeling analysis. J Orthop Res. 2021 08; 39(8):1732-1744. PMID: 32816312.
      Citations:    
    5. Cvetanovich GL, Farkas GJ, Beck EC, Malloy P, Jan K, Espinoza-Orias A, Nho SJ. Squat and gait biomechanics 6 months following hip arthroscopy for femoroacetabular impingement syndrome. J Hip Preserv Surg. 2020 Jan; 7(1):27-37. PMID: 32382426.
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    6. Cabarcas BC, Cvetanovich GL, Espinoza-Orias AA, Inoue N, Gowd AK, Bernardoni E, Verma NN. Novel 3-dimensionally printed patient-specific guide improves accuracy compared with standard total shoulder arthroplasty guide: a cadaveric study. JSES Open Access. 2019 Jul; 3(2):83-92. PMID: 31334434.
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    7. Louie PK, Espinoza Or?as AA, Fogg LF, LaBelle M, An HS, Andersson GBJ. Changes in Lumbar Endplate Area and Concavity Associated With Disc Degeneration. Spine (Phila Pa 1976). 2018 Oct 01; 43(19):E1127-E1134. PMID: 29596278.
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    8. Yang SH, Espinoza Or?as AA, Pan CC, Senoo I, Andersson GBJ, An HS, Inoue N. Spatial geometric and magnetic resonance signal intensity changes with advancing stages of nucleus pulposus degeneration. BMC Musculoskelet Disord. 2017 Nov 21; 18(1):473. PMID: 29162082.
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    9. Basques BA, Espinoza Or?as AA, Shifflett GD, Fice MP, Andersson GB, An HS, Inoue N. The Kinematics and Spondylosis of the Lumbar Spine Vary Depending on the Levels of Motion Segments in Individuals With Low Back Pain. Spine (Phila Pa 1976). 2017 Jul 01; 42(13):E767-E774. PMID: 27831966.
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    10. Kishimoto M, Akeda K, Sudo A, Espinoza Or?as AA, Inoue N. In vivo measurement of vertebral endplate surface area along the whole-spine. J Orthop Res. 2016 08; 34(8):1418-30. PMID: 27346338.
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    11. Zhou J, Espinoza Or?as AA, Kang X, He J, Zhang Z, Inoue N, An HS. CT-based morphometric analysis of the occipital condyle: focus on occipital condyle screw insertion. J Neurosurg Spine. 2016 Nov; 25(5):572-579. PMID: 27341056.
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    12. Wuerz TH, Song SH, Grzybowski JS, Martin HD, Mather RC, Salata MJ, Espinoza Or?as AA, Nho SJ. Capsulotomy Size Affects Hip Joint Kinematic Stability. Arthroscopy. 2016 08; 32(8):1571-80. PMID: 27212048.
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    13. Espinoza Or?as AA, Mammoser NM, Triano JJ, An HS, Andersson GB, Inoue N. Effects of Axial Torsion on Disc Height Distribution: An In Vivo Study. J Manipulative Physiol Ther. 2016 05; 39(4):294-303. PMID: 27059249.
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    14. Farkas GJ, Cvetanovich GL, Rajan KB, Espinoza Or?as AA, Nho SJ. Impact of Femoroacetabular Impingement Morphology on Gait Assessment in Symptomatic Patients. Sports Health. 2015 Sep-Oct; 7(5):429-36. PMID: 26502419.
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    15. Munns JJ, Lee JY, Espinoza Or?as AA, Takatori R, Andersson GB, An HS, Inoue N. Ligamentum flavum hypertrophy in asymptomatic and chronic low back pain subjects. PLoS One. 2015; 10(5):e0128321. PMID: 26010138.
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    16. Abrams GD, Hart MA, Takami K, Bayne CO, Kelly BT, Espinoza Or?as AA, Nho SJ. Biomechanical Evaluation of Capsulotomy, Capsulectomy, and Capsular Repair on Hip Rotation. Arthroscopy. 2015 Aug; 31(8):1511-7. PMID: 25882176.
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    17. Yamaguchi T, Goto S, Nishigaki Y, Espinoza Or?as AA, Bae WC, Masuda K, Inoue N. Microstructural analysis of three-dimensional canal network in the rabbit lumbar vertebral endplate. J Orthop Res. 2015 Feb; 33(2):270-6. PMID: 25367593.
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    18. Senoo I, Espinoza Or?as AA, An HS, Andersson GB, Park DK, Triano JJ, Inoue N. In vivo 3-dimensional morphometric analysis of the lumbar foramen in healthy subjects. Spine (Phila Pa 1976). 2014 Jul 15; 39(16):E929-35. PMID: 24825158.
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    19. Bayne CO, Stanley R, Simon P, Espinoza-Orias A, Salata MJ, Bush-Joseph CA, Inoue N, Nho SJ. Effect of capsulotomy on hip stability-a consideration during hip arthroscopy. Am J Orthop (Belle Mead NJ). 2014 Apr; 43(4):160-5. PMID: 24730000.
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    20. Hong JT, Qasim M, Espinoza Or?as AA, Natarajan RN, An HS. A biomechanical comparison of three different posterior fixation constructs used for c6-c7 cervical spine immobilization: a finite element study. Neurol Med Chir (Tokyo). 2014; 54(9):727-35. PMID: 24418790.
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    21. O'Keefe JA, Espinoza Or?as AA, Khan H, Hall DA, Berry-Kravis E, Wimmer MA. Implementation of a markerless motion analysis method to quantify hyperkinesis in males with fragile X syndrome. Gait Posture. 2014 Feb; 39(2):827-30. PMID: 24252602.
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    22. Nho SJ, Freedman RL, Federer AE, Mather RC, Espinoza Orias AA, Wang VM, Van Thiel GS. Computed tomographic analysis of curved and straight guides for placement of suture anchors for acetabular labral refixation. Arthroscopy. 2013 Oct; 29(10):1623-7. PMID: 24075612.
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    23. Kang RW, Yanke AB, Espinoza Orias AA, Orias AE, Inoue N, Nho SJ. Emerging ideas: Novel 3-D quantification and classification of cam lesions in patients with femoroacetabular impingement. Clin Orthop Relat Res. 2013 Feb; 471(2):358-62. PMID: 23129477.
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    24. Frank RM, Alland J, Grumet RC, Slabaugh MA, Williams JM, Wang VM, Espinoza Orias AA, Bach BR, Nho SJ. Hip osseous morphology using computer navigation and plain radiographs. Am J Orthop (Belle Mead NJ). 2012 Nov; 41(11):519-25. PMID: 23431516.
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    25. Showalter BL, Beckstein JC, Martin JT, Beattie EE, Espinoza Or?as AA, Schaer TP, Vresilovic EJ, Elliott DM. Comparison of animal discs used in disc research to human lumbar disc: torsion mechanics and collagen content. Spine (Phila Pa 1976). 2012 Jul 01; 37(15):E900-7. PMID: 22333953.
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    26. Takigawa T, Simon P, Espinoza Or?as AA, Hong JT, Ito Y, Inoue N, An HS. Biomechanical comparison of occiput-C1-C2 fixation techniques: C0-C1 transarticular screw and direct occiput condyle screw. Spine (Phila Pa 1976). 2012 May 20; 37(12):E696-701. PMID: 22158063.
      Citations:    
    27. Simon P, Espinoza Or?as AA, Andersson GB, An HS, Inoue N. In vivo topographic analysis of lumbar facet joint space width distribution in healthy and symptomatic subjects. Spine (Phila Pa 1976). 2012 May 20; 37(12):1058-64. PMID: 22433501.
      Citations:    
    28. Watanabe S, Inoue N, Yamaguchi T, Hirano Y, Espinoza Or?as AA, Nishida S, Hirose Y, Mizuno J. Three-dimensional kinematic analysis of the cervical spine after anterior cervical decompression and fusion at an adjacent level: a preliminary report. Eur Spine J. 2012 May; 21(5):946-55. PMID: 22124708.
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    29. Inoue N, Espinoza Or?as AA. Biomechanics of intervertebral disk degeneration. Orthop Clin North Am. 2011 Oct; 42(4):487-99, vii. PMID: 21944586.
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    30. Bhatia A, Albazzaz M, Espinoza Or?as AA, Inoue N, Miller LM, Acerbo A, George A, Sumner DR. Overexpression of DMP1 accelerates mineralization and alters cortical bone biomechanical properties in vivo. J Mech Behav Biomed Mater. 2012 Jan; 5(1):1-8. PMID: 22100074.
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    31. Hong JT, Takigawa T, Udayakunmar R, Shin HK, Simon P, Espinoza Or?as AA, Inoue N, An HS. Biomechanical effect of the C2 laminar decortication on the stability of C2 intralaminar screw construct and biomechanical comparison of C2 intralaminar screw and C2 pars screw. Neurosurgery. 2011 Sep; 69(1 Suppl Operative):ons1-6; discussion ons6-7. PMID: 21415794.
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    32. Rudy DJ, Deuerling JM, Espinoza Or?as AA, Roeder RK. Anatomic variation in the elastic inhomogeneity and anisotropy of human femoral cortical bone tissue is consistent across multiple donors. J Biomech. 2011 Jun 03; 44(9):1817-20. PMID: 21543070.
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    33. Hong JT, Tomoyuki T, Udayakumar R, Espinoza Or?as AA, Inoue N, An HS. Biomechanical comparison of three different types of C7 fixation techniques. Spine (Phila Pa 1976). 2011 Mar 01; 36(5):393-8. PMID: 21325933.
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    34. Piasecki DP, Bach BR, Espinoza Orias AA, Verma NN. Anterior cruciate ligament reconstruction: can anatomic femoral placement be achieved with a transtibial technique? Am J Sports Med. 2011 Jun; 39(6):1306-15. PMID: 21335345.
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    35. Hong JT, Takigawa T, Sugisaki K, Espinoza Or?as AA, Inoue N, An HS. Biomechanical and morphometric evaluation of occipital condyle for occipitocervical segmental fixation. Neurol Med Chir (Tokyo). 2011; 51(10):701-6. PMID: 22027245.
      Citations:    
    36. Duan CY, Espinoza Or?as AA, Shott S, An HS, Andersson GB, Hu JZ, Lu HB, Inoue N. In vivo measurement of the subchondral bone thickness of lumbar facet joint using magnetic resonance imaging. Osteoarthritis Cartilage. 2011 Jan; 19(1):96-102. PMID: 21034837.
      Citations:    
    37. Takigawa T, Espinoza Or?as AA, An HS, Gohgi S, Udayakumar RK, Sugisaki K, Natarajan RN, Wimmer MA, Inoue N. Spinal kinematics and facet load transmission after total disc replacement. Spine (Phila Pa 1976). 2010 Oct 15; 35(22):E1160-6. PMID: 20881657.
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    38. Otsuka Y, An HS, Ochia RS, Andersson GB, Espinoza Or?as AA, Inoue N. In vivo measurement of lumbar facet joint area in asymptomatic and chronic low back pain subjects. Spine (Phila Pa 1976). 2010 Apr 15; 35(8):924-8. PMID: 20354471.
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    39. Ritacco LE, Espinoza Or?as AA, Aponte-Tinao L, Muscolo DL, de Quir?s FG, Nozomu I. Three-dimensional morphometric analysis of the distal femur: a validity method for allograft selection using a virtual bone bank. Stud Health Technol Inform. 2010; 160(Pt 2):1287-90. PMID: 20841892.
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    40. Sugisaki K, An HS, Espinoza Or?as AA, Rhim R, Andersson GB, Inoue N. In vivo three-dimensional morphometric analysis of the lumbar pedicle isthmus. Spine (Phila Pa 1976). 2009 Nov 15; 34(24):2599-604. PMID: 19910763.
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    41. Deuerling JM, Yue W, Espinoza Or?as AA, Roeder RK. Specimen-specific multi-scale model for the anisotropic elastic constants of human cortical bone. J Biomech. 2009 Sep 18; 42(13):2061-7. PMID: 19664772.
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    42. Espinoza Or?as AA, Deuerling JM, Landrigan MD, Renaud JE, Roeder RK. Anatomic variation in the elastic anisotropy of cortical bone tissue in the human femur. J Mech Behav Biomed Mater. 2009 Jul; 2(3):255-63. PMID: 19627830.
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    43. Espinoza Or?as AA, Malhotra NR, Elliott DM. Rat disc torsional mechanics: effect of lumbar and caudal levels and axial compression load. Spine J. 2009 Mar; 9(3):204-9. PMID: 18495544.
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