"Integrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
| Descriptor ID |
D016023
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| MeSH Number(s) |
D12.776.543.750.705.408
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Integrins".
Below are MeSH descriptors whose meaning is more specific than "Integrins".
This graph shows the total number of publications written about "Integrins" by people in this website by year, and whether "Integrins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrins" by people in Profiles.
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SuPAR mediates viral response proteinuria by rapidly changing podocyte function. Nat Commun. 2023 07 21; 14(1):4414.
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A Genetic Model of Constitutively Active Integrin CD11b/CD18. J Immunol. 2020 11 01; 205(9):2545-2553.
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Anti-a4?7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals. Sci Transl Med. 2018 10 03; 10(461).
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Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus. J Diabetes Res. 2017; 2017:3232848.
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Pseudomonas aeruginosa ExoT Induces Atypical Anoikis Apoptosis in Target Host Cells by Transforming Crk Adaptor Protein into a Cytotoxin. PLoS Pathog. 2015 May; 11(5):e1004934.
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Sphingomyelinase-like phosphodiesterase 3b expression levels determine podocyte injury phenotypes in glomerular disease. J Am Soc Nephrol. 2015 Jan; 26(1):133-47.
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Integrin av?6 promotes an osteolytic program in cancer cells by upregulating MMP2. Cancer Res. 2014 Mar 01; 74(5):1598-608.
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ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy. J Orthop Res. 2013 Oct; 31(10):1540-8.
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Soluble urokinase receptor and focal segmental glomerulosclerosis. Curr Opin Nephrol Hypertens. 2012 Jul; 21(4):428-32.
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Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling. PLoS One. 2009 Oct 27; 4(10):e7627.