"RNA Interference" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
| Descriptor ID |
D034622
|
| MeSH Number(s) |
G05.308.203.374.790
|
| Concept/Terms |
RNA Interference- RNA Interference
- Interference, RNA
- Gene Silencing, Post-Transcriptional
- Gene Silencing, Post Transcriptional
- RNA Silencing
- Post-Transcriptional Gene Silencing
- Post Transcriptional Gene Silencing
- Post-Transcriptional Gene Silencings
- Silencing, Post-Transcriptional Gene
- RNAi
- Posttranscriptional Gene Silencing
- Gene Silencing, Posttranscriptional
- Gene Silencings, Posttranscriptional
|
Below are MeSH descriptors whose meaning is more general than "RNA Interference".
Below are MeSH descriptors whose meaning is more specific than "RNA Interference".
This graph shows the total number of publications written about "RNA Interference" by people in this website by year, and whether "RNA Interference" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 3 | 3 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 4 | 4 |
| 2015 | 1 | 2 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 2 | 2 |
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Below are the most recent publications written about "RNA Interference" by people in Profiles.
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The role of Runx2 in facilitating autophagy in metastatic breast cancer cells. J Cell Physiol. 2018 Jan; 233(1):559-571.
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Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium Overload. Oxid Med Cell Longev. 2017; 2017:5750897.
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Cdk5r1 Overexpression Induces Primary ?-Cell Proliferation. J Diabetes Res. 2016; 2016:6375804.
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Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy. Brain. 2015 Dec; 138(Pt 12):3555-66.
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Cell-type phylogenetics and the origin of endometrial stromal cells. Cell Rep. 2015 Mar 03; 10(8):1398-409.
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BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization. J Pathol. 2015 Apr; 235(5):731-44.
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Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells. Breast Cancer Res. 2014 Jan 30; 16(1):R16.
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Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: positive and negative effects. Brain Res. 2014 Mar 06; 1550:47-60.
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Gene therapy for Huntington's disease. Neurobiol Dis. 2012 Nov; 48(2):243-54.
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Early growth response-2 expression in uterine leiomyoma cells: regulation and function. Fertil Steril. 2011 Aug; 96(2):439-44.