 Cocaine
"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
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| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.869.388 D04.075.080.875.099.722.388
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 1 | 0 | 1 | | 1990 | 1 | 0 | 1 | | 1991 | 2 | 0 | 2 | | 1993 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1996 | 2 | 0 | 2 | | 1998 | 2 | 0 | 2 | | 1999 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2004 | 2 | 0 | 2 | | 2005 | 3 | 1 | 4 | | 2006 | 1 | 1 | 2 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2010 | 2 | 1 | 3 | | 2011 | 3 | 0 | 3 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 1 | 2 | | 2015 | 3 | 0 | 3 | | 2017 | 0 | 1 | 1 | | 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Christian DT, Stefanik MT, Bean LA, Loweth JA, Wunsch AM, Funke JR, Briggs CA, Lyons J, Neal D, Milovanovic M, D'Souza GX, Stutzmann GE, Nicholson DA, Tseng KY, Wolf ME. GluN3-Containing NMDA Receptors in the Rat Nucleus Accumbens Core Contribute to Incubation of Cocaine Craving. J Neurosci. 2021 09 29; 41(39):8262-8277.
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Nigro SE, Wu M, C Juliano A, Flynn B, Lu LH, Landay AL, French AL, Yang S. Effects of cocaine and HIV on decision-making abilities. J Neurovirol. 2021 06; 27(3):422-433.
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Napier TC. Impact on Cortical Function of Cocaine Abuse Co-Occurring with HIV. Neuropsychopharmacology. 2017 01; 42(1):365.
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Wayman WN, Chen L, Hu XT, Napier TC. HIV-1 Transgenic Rat Prefrontal Cortex Hyper-Excitability is Enhanced by Cocaine Self-Administration. Neuropsychopharmacology. 2016 07; 41(8):1965-73.
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Wayman WN, Chen L, Napier TC, Hu XT. Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat. Eur J Neurosci. 2015 May; 41(9):1195-206.
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Wayman WN, Chen L, Persons AL, Napier TC. Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine. Curr HIV Res. 2015; 13(1):80-7.
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Deng JV, Wan Y, Wang X, Cohen S, Wetsel WC, Greenberg ME, Kenny PJ, Calakos N, West AE. MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity. J Neurosci. 2014 Mar 26; 34(13):4519-27.
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Napier TC, Chen L, Kashanchi F, Hu XT. Repeated cocaine treatment enhances HIV-1 Tat-induced cortical excitability via over-activation of L-type calcium channels. J Neuroimmune Pharmacol. 2014 Jun; 9(3):354-68.
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Sanchez EJ, Hayes RP, Barr JT, Lewis KM, Webb BN, Subramanian AK, Nissen MS, Jones JP, Shelden EA, Sorg BA, Fill M, Schenk JO, Kang C. Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine. Drug Alcohol Depend. 2013 Dec 01; 133(2):344-51.
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Lutgen V, Kong L, Kau KS, Madayag A, Mantsch JR, Baker DA. Time course of cocaine-induced behavioral and neurochemical plasticity. Addict Biol. 2014 Jul; 19(4):529-38.
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