"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 2 | 0 | 2 |
| 2005 | 3 | 1 | 4 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2010 | 2 | 1 | 3 |
| 2011 | 3 | 0 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Cocaine Self-Administration Influences Central Nervous System Immune Responses in Male HIV-1 Transgenic Rats. Cells. 2022 08 04; 11(15).
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Impact on Cortical Function of Cocaine Abuse Co-Occurring with HIV. Neuropsychopharmacology. 2017 01; 42(1):365.
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HIV-1 Transgenic Rat Prefrontal Cortex Hyper-Excitability is Enhanced by Cocaine Self-Administration. Neuropsychopharmacology. 2016 07; 41(8):1965-73.
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Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat. Eur J Neurosci. 2015 May; 41(9):1195-206.
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Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine. Curr HIV Res. 2015; 13(1):80-7.
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MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity. J Neurosci. 2014 Mar 26; 34(13):4519-27.
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Repeated cocaine treatment enhances HIV-1 Tat-induced cortical excitability via over-activation of L-type calcium channels. J Neuroimmune Pharmacol. 2014 Jun; 9(3):354-68.
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Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine. Drug Alcohol Depend. 2013 Dec 01; 133(2):344-51.
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Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala. PLoS One. 2011; 6(9):e25639.
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Cocaine withdrawal reduces group I mGluR-mediated long-term potentiation via decreased GABAergic transmission in the amygdala. Eur J Neurosci. 2011 Jul; 34(2):177-89.