 Core Binding Factor Alpha 2 Subunit
"Core Binding Factor Alpha 2 Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
| Descriptor ID |
D050676
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| MeSH Number(s) |
D12.776.930.155.200.200
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| Concept/Terms |
Core Binding Factor Alpha 2 Subunit- Core Binding Factor Alpha 2 Subunit
- Runx1 Protein
- Pebp2a2 Protein
- Runt-Related Transcription Factor 1
- Runt Related Transcription Factor 1
- Acute Myeloid Leukemia 1 Protein
- Core-Binding Factor Alpha 2 Protein
- Core Binding Factor Alpha 2 Protein
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Below are MeSH descriptors whose meaning is more general than "Core Binding Factor Alpha 2 Subunit".
Below are MeSH descriptors whose meaning is more specific than "Core Binding Factor Alpha 2 Subunit".
This graph shows the total number of publications written about "Core Binding Factor Alpha 2 Subunit" by people in this website by year, and whether "Core Binding Factor Alpha 2 Subunit" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Core Binding Factor Alpha 2 Subunit" by people in Profiles.
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Bakshi R, Hassan MQ, Pratap J, Lian JB, Montecino MA, van Wijnen AJ, Stein JL, Imbalzano AN, Stein GS. The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes. J Cell Physiol. 2010 Nov; 225(2):569-76.
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Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol. 2005 Apr; 203(1):133-43.
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Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, van Wijnen AJ, Lian JB, Stein GS. The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep. 2005 Feb; 6(2):128-33.
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