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Shah, Raj
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overview Professor, Family & Preventive Medicine and the Rush Alzheimer’s Disease Center Overview: My academic career interest is the design of team-based, collaborative science infrastructures that generate impactful knowledge through clinical trials and other discovery research. My overall goal is to develop dynamic and adaptive systems to conduct clinical trials with diverse communities for the maintenance of disability-free survival. I am also the Rush site principal investigator for the Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN), a consortium of academic health systems and other partners working to develop, test and implement strategies to improve care for diverse residents in the Chicago region to improve health care quality, health outcomes and health equity. I am the Rush site principal investigator for the All of Us Research Program of the NIH’s Precision Medicine Initiative. I also am an Associate Director of the Institute for Translational Medicine (ITM) as Cluster Leader for the Network Capacity Cluster. In this NIH funded CTSA program, I oversee the work to streamline clinical research startup and achieve more rapid recruitment at multiple ITM academic institutions. I was a member of the Rush Institutional Review Board for almost 15 years and has served on various other research-focused committees and leadership roles at Rush including the Assistant Vice-Provost, Clinical Research, Rush University. I have been the overall principal investigator for two investigator initiated clinical trials and one SBIR clinical trial. I am on the international steering committee investigator for the recently completed ASPirin in Reducing Events in the Elderly (ASPREE now ASPREE-XT) clinical trial and for the recently funded PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE) clinical trial. I have been the Rush site principal investigator for federally sponsored, foundation sponsored, and industry sponsored Alzheimer’s disease related (over 25) and other common age-related conditions such as COVID-19 along with being a Rush sub-investigator on many other clinical trials. My research manuscripts focus on non-neurological, modifiable factors associated with disability-free longevity in aging, novel clinical trial design and implementation, and health equity. I also was an editor of the book Community Health Equity: A Chicago Reader published by the University of Chicago Press in 2019. I also have provided support for ongoing longitudinal research and infrastructure projects on memory and aging, including the Chicago Health and Aging Project, the Rush Memory and Aging Project, the Rush Religious Orders Study, the Rush Minority Aging and Research Study, the Rush Alzheimer’s Disease Core Center, the Rush Alzheimer’s Disease Assistance Center, the Rush Center of Excellence on Disparities in HIV and Aging, and the Rush Memory Clinic Data and Specimen Repository. I have led education, community engagement and recruitment efforts of the Rush Alzheimer’s Disease Center, especially in communities under-represented in aging research. I am the co-Director of the Center for Community Health Equity, an initiative jointly led by Rush University Medical Center and DePaul University designed to reduce hardship and improve health outcomes in Chicago. I also have provided mentorship to diverse students interested in the health sciences at the high school, college, graduate and post-graduate levels, especially through two well-established summer internship program he co-designed with other faculty. I have been an Executive Committee member of the Rush Mentoring Program and have served as a thesis advisor in the Master of Science in Clinical Research of The Graduate College. I have served as faculty on federally funded institutional (T32) training grants and have been a co-mentor and/or advisor on federally funded career development (K series) grants. He has developed and taught curriculum for the Family Medicine Leadership Program and the Master of Science in Clinical Research at Rush. Education: BS, Northwestern University – Evanston, Illinois (Chemical Engineering) MD, University of Illinois at Chicago College of Medicine – Chicago, Illinois (Medicine) Residency, West Suburban Hospital & Medical Center – Oak Park, Illinois (Family Medicine) Fellowship, Rush University Medical Center – Chicago, Illinois (Geriatric Medicine) My ORCID is 0000-0001-9706-9730. My Scopus ID is 10046255700. My NIH COMMONS name is rshah1
One or more keywords matched the following items that are connected to Shah, Raj
Item TypeName
Concept Aged, 80 and over
Concept Aged
Concept Homes for the Aged
Concept Middle Aged
Concept Frail Elderly
Academic Article An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease.
Academic Article Hemoglobin level in older persons and incident Alzheimer disease: prospective cohort analysis.
Academic Article Antihypertensive and Statin Medication Use and Motor Function in Community-Dwelling Older Adults.
Academic Article Personality and incident disability in older persons.
Academic Article Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease.
Academic Article Mixed pathology is more likely in black than white decedents with Alzheimer dementia.
Academic Article Relation of blood pressure to risk of incident Alzheimer's disease and change in global cognitive function in older persons.
Academic Article Relation of driving status to incident life space constriction in community-dwelling older persons: a prospective cohort study.
Academic Article Blood pressure and lower limb function in older persons.
Academic Article Clinical-pathologic study of depressive symptoms and cognitive decline in old age.
Academic Article Relation of hemoglobin to level of cognitive function in older persons.
Academic Article The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community population.
Academic Article Association of lower hemoglobin level and neuropathology in community-dwelling older persons.
Academic Article Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment.
Academic Article Age-related changes in the mesial temporal lobe: the parahippocampal white matter region.
Academic Article Harm avoidance and disability in old age.
Academic Article Late-life depression is not associated with dementia-related pathology.
Academic Article Alzheimer's disease: Unique markers for diagnosis & new treatment modalities.
Academic Article Association of total daily physical activity with disability in community-dwelling older persons: a prospective cohort study.
Academic Article Atrophy and dysfunction of parahippocampal white matter in mild Alzheimer's disease.
Academic Article Relationship between Auditory and Cognitive Abilities in Older Adults.
Academic Article Recruitment and enrollment of caregivers for a lifestyle physical activity clinical trial.
Academic Article An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease.
Academic Article The Minority Aging Research Study: ongoing efforts to obtain brain donation in African Americans without dementia.
Academic Article Total daily physical activity and longevity in old age.
Academic Article Musculoskeletal pain is associated with incident mobility disability in community-dwelling elders.
Academic Article Daytime sleepiness in mild Alzheimer's disease with and without parkinsonian features.
Academic Article Cognitive decline in older persons initiating anticholinergic medications.
Academic Article Musculoskeletal pain and incident disability in community-dwelling older adults.
Academic Article Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study.
Academic Article Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.
Academic Article Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease.
Academic Article Brainstem aminergic nuclei and late-life depressive symptoms.
Academic Article fMRI activation changes during successful episodic memory encoding and recognition in amnestic mild cognitive impairment relative to cognitively healthy older adults.
Academic Article Neuropathology of older persons without cognitive impairment from two community-based studies.
Academic Article Sleepiness, parkinsonian features and sustained attention in mild Alzheimer's disease.
Academic Article Change in risk of Alzheimer disease over time.
Academic Article Total daily physical activity and the risk of AD and cognitive decline in older adults.
Academic Article Change in body mass index and risk of incident Alzheimer disease.
Academic Article MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD.
Academic Article Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults.
Academic Article Age-related changes in parahippocampal white matter integrity: a diffusion tensor imaging study.
Academic Article Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study.
Academic Article Effect Size Analyses of Souvenaid in Patients with Alzheimer's Disease.
Academic Article Association of cognitive activity and neurocognitive function in blacks and whites with HIV.
Academic Article Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology.
Academic Article Purpose in Life and Hospitalization for Ambulatory Care-Sensitive Conditions in Old Age.
Academic Article Psychometric properties of a short form of the Center for Epidemiologic Studies Depression (CES-D-10) scale for screening depressive symptoms in healthy community dwelling older adults.
Academic Article The aspirin in reducing events in the elderly trial: Statistical analysis plan.
Academic Article Willingness to Be a Brain Donor: A Survey of Research Volunteers From 4 Racial/Ethnic Groups.
Academic Article Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5.
Academic Article Circulating Dkk1 and TRAIL Are Associated With Cognitive Decline in Community-Dwelling, Older Adults With Cognitive Concerns.
Academic Article Memory complaints, dementia, and neuropathology in older blacks and whites.
Academic Article ASPREE-D: Aspirin for the prevention of depression in the elderly
Academic Article Kidney function is associated with the rate of cognitive decline in the elderly
Academic Article A Population-Based Study of Hemoglobin, Race, and Mortality in the Elderly
Academic Article Effect of Antidepressant Medication Use and Social Engagement on the Level of Depressive Symptoms in Community-Dwelling, Older African Americans and Whites With Dementia.
Academic Article Hospital Volume of Immunosuppressed Patients with Sepsis and Sepsis Mortality.
Academic Article Trends in diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in India: A report of multicenter data from a web-based registry.
Academic Article Association of Financial Literacy With Hospitalization in Community-dwelling Older Adults.
Academic Article Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.
Academic Article Normative performance of healthy older individuals on the Modified Mini-Mental State (3MS) examination according to ethno-racial group, gender, age, and education level.
Academic Article Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology.
Academic Article Association of community-level inequities and premature mortality: Chicago, 2011-2015.
Academic Article Effect of Aspirin on All-Cause Mortality in the Healthy Elderly.
Academic Article Effect of Aspirin on Disability-free Survival in the Healthy Elderly.
Academic Article Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.
Academic Article Racial disparities in eligibility for low-dose computed tomography lung cancer screening among older adults with a history of smoking.
Academic Article Score for Predicting Ventilator Weaning Duration in Patients With Tracheostomies.
Academic Article Quality of Life for 19,114 participants in the ASPREE (ASPirin in Reducing Events in the Elderly) study and their association with sociodemographic and modifiable lifestyle risk factors.
Academic Article Cognitive decline after elective and nonelective hospitalizations in older adults.
Academic Article Baseline Characteristics of Participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study.
Academic Article Prevalence of depressive symptoms and its associated factors among healthy community-dwelling older adults living in Australia and the United States.
Academic Article Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study.
Academic Article Attitudes toward advance care planning among persons with dementia and their caregivers.
Academic Article Alzheimer's disease frequency peaks in the tenth decade and is lower afterwards.
Academic Article A Multidisciplinary Team-Based Approach to Improve Communication With Surrogates of Patients With Chronic Critical Illness.
Academic Article Hospitalization, Alzheimer's Disease and Related Neuropathologies, and Cognitive Decline.
Academic Article Factors Associated With Treatment and Control of Hypertension in a Healthy Elderly Population Free of Cardiovascular Disease: A Cross-sectional Study.
Academic Article Aligning the 4Ms of Age-Friendly Health Systems With Statin Use for Primary Prevention.
Academic Article The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly.
Academic Article The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study.
Academic Article Normative performance of older individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) according to ethno-racial group, gender, age and education level.
Academic Article Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline.
Academic Article The Health Equity Through Aging Research And Discussion (HEARD) Study: A Proposed Two-Phase Sequential Mixed-Methods Research Design To Understand Barriers And Facilitators Of Brain Donation Among Diverse Older Adults.
Academic Article Physicians and Alzheimer Dementia: Past, Present, and Future.
Academic Article Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults.
Academic Article Multimodality management, recurrence patterns, and long-term outcome of gastroenteropancreatic neuroendocrine neoplasms: Progress over 17?years.
Academic Article Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial.
Academic Article Impact of the 2017 American Heart Association and American College of Cardiology hypertension guideline in aged individuals.
Academic Article Effect of Aspirin on Cancer Incidence and Mortality in Older Adults.
Academic Article Representation of Older Latinxs in Cohort Studies at the Rush Alzheimer's Disease Center.
Academic Article Subgroup analysis of the ASPirin in Reducing Events in the Elderly randomized clinical trial suggests aspirin did not improve outcomes in older adults with chronic kidney disease.
Academic Article Perceived Impediments to Completed Brain Autopsies Among Diverse Older Adults Who Have Signed a Uniform Anatomical Gift Act for Brain Donation for Clinical Research.
Academic Article DNA methylation analysis of candidate genes associated with dementia in peripheral blood.
Academic Article Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults.
Academic Article Psychological Symptoms Among Surrogates of Critically Ill Patients During and Before the COVID-19 Pandemic.
Academic Article Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial.
Academic Article The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia.
Academic Article Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population.
Academic Article Effect of Statin Therapy on Cognitive?Decline and Incident Dementia?in Older Adults.
Academic Article Long-Term Blood Pressure Variability and Risk of Cognitive Decline and Dementia Among Older Adults.
Academic Article Validation of a Deficit-Accumulation Frailty Index in the ASPirin in Reducing Events in the Elderly Study and Its Predictive Capacity for Disability-Free Survival.
Academic Article Similar mortality risk in incident cognitive impairment and dementia: Evidence from the ASPirin in Reducing Events in the Elderly (ASPREE) trial.
Academic Article The Effect of Low-Dose Aspirin on Frailty Phenotype and Frailty Index in Community-Dwelling Older Adults in the ASPirin in Reducing Events in the Elderly Study.
Academic Article Brain-predicted age difference is associated with cognitive processing in later-life.
Academic Article Anticholinergic medication burden and cognitive function in participants of the ASPREE study.
Academic Article Safety of Ceasing Aspirin Used Without a Clinical Indication After Age 70 Years: A Subgroup Analysis of the ASPREE Randomized Trial.
Academic Article Derivation and validation of the Rapid Assessment of Dementia Risk (RADaR) for older adults.
Academic Article The association between polypharmacy, frailty and disability-free survival in community-dwelling healthy older individuals.
Academic Article Prediction of disability-free survival in healthy older people.
Academic Article Effect of Aspirin on CKD Progression in Older Adults: Secondary Analysis From the ASPREE Randomized Clinical Trial.
Academic Article Test-Retest Reliability and Minimal Detectable Change of Four Cognitive Tests in Community-Dwelling Older Adults.
Academic Article Association of Dual Decline in Cognition and Gait Speed With Risk of Dementia in Older Adults.
Academic Article Health Characteristics and Aspirin Use in Participants at the Baseline of the ASPirin in Reducing Events in the Elderly - eXTension (ASPREE-XT) Observational Study.
Academic Article Association Between Triglycerides and Risk of Dementia in Community-Dwelling Older Adults: A Prospective Cohort Study.
Academic Article The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study.
Academic Article Cognitive trajectories and incident dementia after a cardiovascular event in older adults.
Academic Article Lifestyle Enrichment in Later Life and Its Association With Dementia Risk.
Academic Article Low-Dose Aspirin and the Risk of Stroke and Intracerebral Bleeding in Healthy Older People: Secondary Analysis of a Randomized Clinical Trial.
Academic Article Prediabetes, diabetes and loss of disability-free survival in a community-based older cohort: a post-hoc analysis of the ASPirin in Reducing Events in the Elderly trial.
Academic Article Trajectories of depressive symptoms in older adults and associated health outcomes.
Academic Article The Relationship of John Henryism With Cognitive Function and Decline in Older Black Adults.
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