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One or more keywords matched the following properties of Landay, Alan
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overview Other Appointments: The Thomas J. Coogan, Sr., MD, Chair of Immunology, Rush Medical College. Alan L. Landay, PhD, is the professor of the Department of Immunity & Emerging Pathogens and principal investigator of the Rush Immunology Specialty Laboratory, or ISL, with 35 years experience in studies of HIV immunopathogenesis. He has worked with the AIDS Clinical Trials Group since its beginning and has directed the ISL since it began. His studies on immunophenotyping and innate immunity in HIV disease have made significant contributions to this field. These early studies were carried out in a newly recognized population of hemophiliacs that were shown to develop AIDS. This work was extended with more recent publications using multi-parameter flow cytometry to define monocyte subsets and the critical role of monocytes and innate immune cell activation in HIV pathogenesis. These papers have contributed to a shift in thinking about HIV as an adaptive immune disease to one focused on innate cell driven inflammation linked to the development of immunosenescence. My Scopus ID is 14325119400. My NIH COMMONS name is ALANDAY. Research Areas: HIV/AIDS, aging. My Faculty Profile at Rush University Medical Center: https://www.rushu.rush.edu/faculty/alan-l-landay-phd My Laboratory: https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-alan-landay-phd My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/pubmed/?term=Landay+A My Scopus: https://www.scopus.com/authid/detail.uri?authorId=14325119400 Education: PhD, University of Pittsburgh Medical School BS, Penn State University
One or more keywords matched the following items that are connected to Landay, Alan
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Concept Monocytes
Academic Article Viremic and Virologically Suppressed HIV Infection Increases Age-Related Changes to Monocyte Activation Equivalent to 12 and 4 Years of Aging, Respectively.
Academic Article Enumeration of human lymphocyte subpopulations by immunofluorescence: a comparative study using automated flow microfluorometry and fluorescence microscopy.
Academic Article Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: implications for immunotherapy.
Academic Article Assessment of interlaboratory variability of immunophenotyping. Results of the College of American Pathologists Flow Cytometry Survey.
Academic Article GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals.
Academic Article IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte/macrophage lineage.
Academic Article HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy.
Academic Article PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes.
Academic Article Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women.
Academic Article A potent activator of HIV-1 replication is present in the genital tract of a subset of HIV-1-infected and uninfected women.
Academic Article CCR5 and CXCR4 expression after highly active antiretroviral therapy (HAART).
Academic Article A human B cell differentiation antigen selectively expressed on mature B cells identified by a monoclonal antibody (HB-2).
Academic Article Analysis of lymphocytes, monocytes, and neutrophils from human immunodeficiency virus (HIV)-infected persons for HIV DNA.
Academic Article Enhancement of human peripheral blood monocyte respiratory burst activity by aggregated C-reactive protein.
Academic Article Isolation of HIV-1 from monocytes of individuals negative by conventional culture.
Academic Article Early reduction of immune activation in lymphoid tissue following highly active HIV therapy.
Academic Article Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women.
Academic Article Decreased oxidative burst activity of monocytes from asymptomatic HIV-infected individuals.
Academic Article Immune responses to abacavir in antigen-presenting cells from hypersensitive patients.
Academic Article Evaluation of human monocyte oxidative metabolism utilizing a flow cytometric assay.
Academic Article CD40 ligand and IFN-gamma synergistically restore IL-12 production in HIV-infected patients.
Academic Article Monocyte functional studies in asymptomatic, human immunodeficiency disease virus (HIV)-infected individuals.
Academic Article Immunologic abnormalities associated with chronic fatigue syndrome.
Academic Article Resumption of HIV replication is associated with monocyte/macrophage derived cytokine and chemokine changes: results from a large international clinical trial.
Academic Article Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function.
Academic Article Oxidative burst capability of human monocyte subsets defined by high and low HLA-DR expression.
Academic Article Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV+ subjects.
Academic Article Brief Report: CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy.
Academic Article Increased glucose transporter-1 expression on intermediate monocytes from HIV-infected women with subclinical cardiovascular disease.
Academic Article Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men.
Academic Article Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection.
Academic Article Loss of CXCR4 on non-classical monocytes in participants of the Women's Interagency HIV Study (WIHS) with subclinical atherosclerosis.
Academic Article Elevated Plasma Ceramides Are Associated With Antiretroviral Therapy Use and Progression of Carotid Artery Atherosclerosis in HIV Infection.
Academic Article Associations of Innate and Adaptive Immune Cell Subsets With Incident Type 2 Diabetes Risk: The MESA Study.
Academic Article Dysfunctional Immunometabolism in HIV Infection: Contributing Factors and Implications for Age-Related Comorbid Diseases.
Academic Article Innate and adaptive immune cell subsets as risk factors for coronary heart disease in two population-based cohorts.
Academic Article Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV.
Academic Article Association of Monocyte Migration Marker CD11b With Pulmonary Function in People Living With HIV.
Academic Article Natural killer cells, gamma delta T cells and classical monocytes are associated with systolic blood pressure in the multi-ethnic study of atherosclerosis (MESA).
Academic Article Nonclassical Monocytes (CD14dimCD16+) Are Associated With Carotid Intima-Media Thickness Progression for Men but Not Women: The Multi-Ethnic Study of Atherosclerosis-Brief Report.
Academic Article Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis.
Academic Article Monocyte subsets, T cell activation profiles, and stroke in men and women: The Multi-Ethnic Study of Atherosclerosis and Cardiovascular Health Study.
Academic Article HIV infection and cardiovascular disease have both shared and distinct monocyte gene expression features: Women's Interagency HIV study.
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