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One or more keywords matched the following properties of Kordower, Jeffrey
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overview Other Appointments: Director, Section of Neurobiology Overview: Kordower is an international authority in the area of movement disorders with special expertise in pathophysiology and experimental therapeutic strategies in Parkinson’s disease, Alzheimer’s disease and Huntington’s disease — especially using nonhuman primate models. He has published landmark papers in the area of cell replacement strategies, including the first demonstration that fetal dopaminergic grafts can survive, innervate and form synapses in patients with Parkinson’s disease that was published in the New England Journal of Medicine. His recent demonstration that long-term grafts in such patients can form Lewy bodies was recently published in Nature Medicine. Kordower has published seminal studies including the lead article in Science demonstrating that gene delivery of the trophic factors GDNF and neurturin can prevent the emergence of motor symptoms and nigrostriatal degeneration in a monkey model of PD. He also was the first to demonstrate that gene delivery of trophic factors can obviate neurodegenerative processes in nonhuman primate models of Huntington’s disease and Alzheimer’s disease, with these studies being published in Nature and The Journal of Comparative Neurology, respectively. He has published numerous papers investigating the role of misfolded proteins in PD pathogenesis. These include papers in human and experimental PD on the role of alpha synuclein misfolding on Nurr1 and dopamine expression, lysosome and proteasome dysfunction, and axonal transport defects. He is a co-author on the landmark Nature paper lead by the Studer group demonstrating the structural and functional efficacy of dopaminergic human stem cells in rodent and nonhuman primate models of PD. In addition, he is collaborating with Trojanowski and Lee and recently demonstrated the ability of preformed fibrils to be transported in nonhuman primates and cause degeneration in nonhuman primates, a study that serves as the foundation of the current application. Kordower has published over 350 papers, has lectured all over the world, has been on over 20 editorial boards, and is on the SAB’s of many biotech companies and scientific organizations. He is a past councilor and past president of the American Society for Neural Transplantation, past chair for the Committee for the Use of Animals for SFN, and is a founding SAB member for the Michael J. Fox Foundation and is a past member of their Executive SAB. My Scopus ID is 7005337450. My NIH COMMONS name is JKORDOWER. Education PhD, Queens College, City University of New York MA, Queens College, City University of New York BA, Queens College, City University of New York
One or more keywords matched the following items that are connected to Kordower, Jeffrey
Item TypeName
Concept Adaptor Proteins, Signal Transducing
Concept Membrane Proteins
Concept Norepinephrine Plasma Membrane Transport Proteins
Concept DNA-Binding Proteins
Concept MADS Domain Proteins
Concept Membrane Transport Proteins
Concept Homeodomain Proteins
Concept Neurofilament Proteins
Concept HSC70 Heat-Shock Proteins
Concept Luminescent Proteins
Concept Carrier Proteins
Concept Vesicular Monoamine Transport Proteins
Concept Green Fluorescent Proteins
Concept Calcium-Binding Proteins
Concept Nuclear Proteins
Concept Recombinant Proteins
Concept Microfilament Proteins
Concept Proto-Oncogene Proteins c-ret
Concept Viral Matrix Proteins
Concept Proto-Oncogene Proteins c-fos
Concept Acute-Phase Proteins
Concept tau Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept Dopamine Plasma Membrane Transport Proteins
Concept Nerve Tissue Proteins
Concept Intercellular Signaling Peptides and Proteins
Concept Microtubule-Associated Proteins
Concept Serotonin Plasma Membrane Transport Proteins
Academic Article Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups.
Academic Article Neuropathological study 16 years after autologous adrenal medullary transplantation in a Parkinson's disease patient.
Academic Article ?-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and ?-amyloid accumulation.
Academic Article Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.
Academic Article Trophic factors for Parkinson's disease: To live or let die.
Academic Article Estrogen increases the number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys.
Academic Article a-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.
Academic Article Gene transfer provides a practical means for safe, long-term, targeted delivery of biologically active neurotrophic factor proteins for neurodegenerative diseases.
Academic Article Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF.
Academic Article Etiology of Parkinson's disease: Genetics and environment revisited.
Academic Article Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys.
Academic Article Nurr1 in Parkinson's disease and related disorders.
Academic Article Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates.
Academic Article Huntington's disease: pathological mechanisms and therapeutic strategies.
Academic Article Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements.
Academic Article Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease.
Academic Article Trophic factor gene therapy for Parkinson's disease.
Academic Article Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.
Academic Article Lewy body pathology in fetal grafts.
Academic Article Transplanted dopaminergic neurons develop PD pathologic changes: a second case report.
Academic Article GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults.
Academic Article Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease.
Academic Article Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy.
Academic Article Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.
Academic Article Gene therapy for Parkinson's disease.
Academic Article Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.
Academic Article Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson's Disease.
Academic Article Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.
Academic Article Proteasome inhibition and Parkinson's disease modeling.
Academic Article RET expression does not change with age in the substantia nigra pars compacta of rhesus monkeys.
Academic Article Neonatal immune-tolerance in mice does not prevent xenograft rejection.
Academic Article Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system.
Academic Article The role of alpha-synuclein in Parkinson's disease: insights from animal models.
Academic Article Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.
Academic Article Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease.
Academic Article Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease.
Academic Article Misfolded proteins in Huntington disease fetal grafts: further evidence of cell-to-cell transfer?
Academic Article Disease duration and the integrity of the nigrostriatal system in Parkinson's disease.
Academic Article Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration.
Academic Article Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
Academic Article Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra.
Academic Article Are growth factors the answer?
Academic Article Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Academic Article RNA amplification of bromodeoxyuridine labeled newborn neurons in the monkey hippocampus.
Academic Article Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease.
Academic Article Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey.
Academic Article Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.
Academic Article Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates.
Academic Article Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with a-synucleinopathies.
Academic Article Kinetic modeling and occupancy measures of the norepinephrine transporters in baboons using single photon emission computed tomography with (123)I-INER.
Academic Article Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.
Academic Article Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors.
Academic Article Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms.
Academic Article Loss of One Engrailed1 Allele Enhances Induced a-Synucleinopathy.
Academic Article Temporal evolution of microglia and a-synuclein accumulation following foetal grafting in Parkinson's disease.
Academic Article Spreading of alpha-synuclein - relevant or epiphenomenon?
Academic Article Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes.
Academic Article Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease.
Academic Article GDNF signaling in subjects with minimal motor deficits and Parkinson's disease.
Academic Article A novel tau-based rhesus monkey model of Alzheimer's pathogenesis.
Academic Article Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies.
Academic Article Mixed pathology as a rule, not exception: Time to reconsider disease nosology.
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