Item Type | Name |
Concept
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Physical Conditioning, Animal
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Concept
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Disease Models, Animal
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Concept
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Animals, Newborn
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Concept
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Animals
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Concept
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Models, Animal
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Concept
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Behavior, Animal
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Academic Article
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Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging.
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Academic Article
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Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1.
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Academic Article
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Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome.
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Academic Article
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Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis.
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Academic Article
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Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.
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Academic Article
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Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation.
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Academic Article
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Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.
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Academic Article
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Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects.
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Academic Article
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The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
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Academic Article
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LXRs regulate the balance between fat storage and oxidation.
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Academic Article
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Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels.
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Academic Article
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Cellular and structural biology of the deiodinases.
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Academic Article
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[Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-Walker mammary carcinoma].
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Academic Article
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Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus.
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Academic Article
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Adaptive activation of thyroid hormone and energy expenditure.
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Academic Article
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Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.
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Academic Article
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Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.
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Academic Article
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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
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Academic Article
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Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms.
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Academic Article
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Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene.
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Academic Article
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Deiodinases: implications of the local control of thyroid hormone action.
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Academic Article
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Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations.
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Academic Article
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The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
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Academic Article
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Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats.
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Academic Article
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Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue.
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Academic Article
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Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.
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Academic Article
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Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.
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Academic Article
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An inside job.
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Academic Article
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Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis.
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Academic Article
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Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
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Academic Article
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Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.
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Academic Article
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Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.
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Academic Article
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Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences.
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Academic Article
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Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide.
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Academic Article
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Reawakened interest in type III iodothyronine deiodinase in critical illness and injury.
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Academic Article
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Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.
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Academic Article
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Metabolic effects of thyroid hormones-beyond traditional prospects.
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Academic Article
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Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus.
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Academic Article
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Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton.
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Academic Article
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Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.
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Academic Article
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Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.
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Academic Article
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Mice lacking brain-type creatine kinase activity show defective thermoregulation.
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Academic Article
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Triumphs of the thyroid despite lesser conversion.
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Academic Article
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Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.
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Academic Article
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Thyroid hormone-related regulation of gene expression in human fatty liver.
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Academic Article
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The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase.
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Academic Article
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A TRbeta-selective agonist confers resistance to diet-induced obesity.
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Academic Article
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Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis.
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Academic Article
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Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway.
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Academic Article
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Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity.
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Academic Article
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Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells.
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Academic Article
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Wnt signaling regulates mitochondrial physiology and insulin sensitivity.
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Academic Article
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Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis.
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Academic Article
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Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment.
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Academic Article
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The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
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Academic Article
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Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
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Academic Article
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Crossing the hurdles of thyroid hormone receptor-a activation.
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Academic Article
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Type 2 deiodinase at the crossroads of thyroid hormone action.
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Academic Article
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Minireview: cracking the metabolic code for thyroid hormone signaling.
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Academic Article
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Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity.
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Academic Article
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The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion.
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Academic Article
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Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features.
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Academic Article
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Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.
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Academic Article
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Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice.
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Academic Article
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A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons.
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Academic Article
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Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
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Academic Article
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?(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice.
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Academic Article
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Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.
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Academic Article
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Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice.
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Academic Article
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Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
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Academic Article
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Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice.
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Academic Article
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Cracking the code for thyroid hormone signaling.
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Academic Article
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American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.
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Academic Article
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Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage.
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Academic Article
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Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse.
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Academic Article
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Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots.
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Academic Article
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The role of thyroid hormone and brown adipose tissue in energy homoeostasis.
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Academic Article
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Thyroid hormone signaling in energy homeostasis and energy metabolism.
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Academic Article
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Inactivation of the adrenergic receptor ?2 disrupts glucose homeostasis in mice.
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Academic Article
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Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic ?-cells and disrupts glucose homeostasis.
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Academic Article
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Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.
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Academic Article
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S-nitrosoglutathione reductase-dependent PPAR? denitrosylation participates in MSC-derived adipogenesis and osteogenesis.
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Academic Article
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Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.
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Academic Article
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New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism.
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Academic Article
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Scope and limitations of iodothyronine deiodinases in hypothyroidism.
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Academic Article
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Coupling between Nutrient Availability and Thyroid Hormone Activation.
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Academic Article
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Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
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Academic Article
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Of rats and men: thyroid homeostasis in rodents and human beings - Authors' reply.
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Academic Article
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Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice.
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Academic Article
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Thyroid hormone activation by type?2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-? coactivator-1a expression in skeletal muscle.
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Academic Article
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Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.
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Academic Article
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Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes.
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Academic Article
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Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold.
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Academic Article
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Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold.
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Academic Article
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Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles.
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Academic Article
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Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors.
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Academic Article
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Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis.
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Academic Article
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Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation.
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Academic Article
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Nuclear 3,5,3'-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques.
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Academic Article
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Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue.
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Academic Article
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The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3'-triiodothyronine generation in rats.
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Academic Article
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Extrathyroidal conversion of thyroxine to 3,5,3'-triiodothyronine in cold-acclimated thyroxine-maintained thyroidectomized rats.
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Academic Article
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Possible mechanism of action of cholesterol enriched diet on the thyroid.
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Academic Article
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Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue.
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Academic Article
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Corticosterone inhibits uncoupling protein gene expression in brown adipose tissue.
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Academic Article
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The use of recombinant human thyrotropin produced by Chinese hamster ovary cells for the preparation of immunoassay reagents.
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Academic Article
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Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity.
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Academic Article
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Effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats.
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Academic Article
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Thyroxine 5'-deiodination mediates norepinephrine-induced lipogenesis in dispersed brown adipocytes.
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Academic Article
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3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity.
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Academic Article
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Development of compensatory thermogenesis in response to overfeeding in hypothyroid rats.
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Academic Article
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Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat.
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Academic Article
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Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.
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Academic Article
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Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy.
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Academic Article
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Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.
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Academic Article
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Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency.
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Academic Article
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The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
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Academic Article
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Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific.
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Academic Article
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Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms.
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Academic Article
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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue.
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Academic Article
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Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats.
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Academic Article
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Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.
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Academic Article
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Adaptive thermogenesis in hummingbirds.
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Academic Article
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betaAR signaling required for diet-induced thermogenesis and obesity resistance.
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Academic Article
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Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.
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Academic Article
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Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis.
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Academic Article
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[Gastrin changes in the gastric antrum G-cells and in serum gastrin levels after 80% jejunoileal resection in rats].
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Academic Article
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[Histologic and histochemical evaluation of the exocrine pancreas in rats subjected to resection or extensive jejunoileal bypass].
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Academic Article
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[Metabolic changes in rats subjected to massive intestinal resection or jejunoileal bypass].
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Academic Article
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Influence of mast cells on thyroid function.
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Academic Article
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Protective effect of the Nramp1 BB genotype against Brucella abortus in the water buffalo (Bubalus bubalis).
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Academic Article
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Impact of a high loading dose of atorvastatin on contrast-induced acute kidney injury.
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Academic Article
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Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse.
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Academic Article
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Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function.
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Academic Article
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Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
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Academic Article
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A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action.
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Academic Article
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The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia.
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Academic Article
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Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.
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Academic Article
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The Deiodinase Trio and Thyroid Hormone Signaling.
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Academic Article
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Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats.
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Academic Article
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Amiodarone and thyroid physiology, pathophysiology, diagnosis and management.
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Academic Article
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Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.
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Academic Article
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Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
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Academic Article
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Paradigms of Dynamic Control of Thyroid Hormone Signaling.
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Academic Article
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Sustained Release T3 Therapy: Animal Models and Translational Applications.
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Academic Article
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Levothyroxine treatment and cholesterol in hypothyroidism.
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Academic Article
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Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism.
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Academic Article
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Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice.
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Academic Article
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Accelerating functional gene discovery in osteoarthritis.
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Academic Article
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Deiodinases and the Metabolic Code for Thyroid Hormone Action.
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Academic Article
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Neonatal thyroxine activation modifies epigenetic programming of the liver.
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Academic Article
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Deiodinase-3 is a thyrostat to regulate podocyte homeostasis.
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Academic Article
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Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse.
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Academic Article
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Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain.
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Academic Article
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T3 levels and thyroid hormone signaling.
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Academic Article
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Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism.
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Academic Article
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Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice.
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Academic Article
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Multisensory Stimulation Improves Cognition and Behavior in Adult Male Rats Born to LT4-treated Thyroidectomized Dams.
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Academic Article
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The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease.
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