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Maki, Carl

One or more keywords matched the following items that are connected to Maki, Carl

Item Type	Name
Concept	Lung Neoplasms
Concept	Tumor Suppressor Protein p14ARF
Concept	Tumor Suppressor Protein p53
Concept	Genes, Tumor Suppressor
Concept	Colorectal Neoplasms
Concept	Neoplasm Proteins
Concept	Drug Resistance, Neoplasm
Concept	Breast Neoplasms
Concept	Bone Neoplasms
Concept	Tumor Cells, Cultured
Concept	Triple Negative Breast Neoplasms
Concept	Neoplasms
Concept	Colonic Neoplasms
Concept	Cell Line, Tumor
Concept	Tumor Suppressor Proteins
Concept	Neoplasm Recurrence, Local
Concept	Liver Neoplasms
Concept	Neoplasm Invasiveness
Academic Article	The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT.
Academic Article	Research findings working with the p53 and Rb1 targeted osteosarcoma mouse model.
Academic Article	Critical roles for nitric oxide and ERK in the completion of prosurvival autophagy in 4OHTAM-treated estrogen receptor-positive breast cancer cells.
Academic Article	Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.
Academic Article	p53-regulated autophagy is controlled by glycolysis and determines cell fate.
Academic Article	Modeling the Etiology of p53-mutated Cancer Cells.
Academic Article	Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.
Academic Article	Physical and functional interactions between PML and MDM2.
Academic Article	Stability and ubiquitination of the tumor suppressor protein p53.
Academic Article	MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53.
Academic Article	A link between p73 transcriptional activity and p73 degradation.
Academic Article	Cdk2-dependent Inhibition of p21 stability via a C-terminal cyclin-binding motif.
Academic Article	Control of p53 nuclear accumulation in stressed cells.
Academic Article	P53 gene alterations identified in classical Hodgkin's lymphoma cell lines.
Academic Article	P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity.
Academic Article	MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation.
Academic Article	Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination.
Academic Article	Transient nutlin-3a treatment promotes endoreduplication and the generation of therapy-resistant tetraploid cells.
Academic Article	Puromycin-based vectors promote a ROS-dependent recruitment of PML to nuclear inclusions enriched with HSP70 and Proteasomes.
Academic Article	Nutlin-3a induces cytoskeletal rearrangement and inhibits the migration and invasion capacity of p53 wild-type cancer cells.
Academic Article	Persistent p21 expression after Nutlin-3a removal is associated with senescence-like arrest in 4N cells.
Academic Article	Decision-making by p53 and mTOR.
Academic Article	p53 and p21(Waf1) are recruited to distinct PML-containing nuclear foci in irradiated and Nutlin-3a-treated U2OS cells.
Academic Article	Pharmacologic activation of p53 by small-molecule MDM2 antagonists.
Academic Article	Glucocorticoid receptor activation inhibits p53-induced apoptosis of MCF10Amyc cells via induction of protein kinase Ce.
Academic Article	Two 4N cell-cycle arrests contribute to cisplatin-resistance.
Academic Article	Novel roles for p53 in the genesis and targeting of tetraploid cancer cells.
Academic Article	Nuclear import and export signals in control of the p53-related protein p73.
Academic Article	The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis.
Academic Article	Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3.
Academic Article	Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells.
Academic Article	MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding.
Academic Article	Transcriptional activation of bovine mimecan by p53 through an intronic DNA-binding site.
Academic Article	Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents.
Academic Article	MDM2-dependent ubiquitination of nuclear and cytoplasmic P53.
Academic Article	The MDM2 RING-finger domain is required to promote p53 nuclear export.
Academic Article	Role and regulation of p53 during an ultraviolet radiation-induced G1 cell cycle arrest.
Academic Article	Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation.
Academic Article	Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2.
Academic Article	Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation.
Academic Article	In vivo ubiquitination and proteasome-mediated degradation of p53(1).
Academic Article	Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells.
Academic Article	The IGF-1R/AKT pathway determines cell fate in response to p53.
Academic Article	p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a.
Academic Article	DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a.
Academic Article	Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a.
Academic Article	JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.
Academic Article	The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells.
Academic Article	Absence of a radiation-induced first-cycle G1-S arrest in p53+ human tumor cells synchronized by mitotic selection.
Academic Article	Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer.
Academic Article	Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells.
Academic Article	P53-regulated autophagy and its impact on drug resistance and cell fate.
Academic Article	Corrigendum to 'Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells'.
Academic Article	RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC.
Academic Article	Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15.
Academic Article	Prolyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer.
Academic Article	Erratum: P53-regulated autophagy and its impact on drug resistance and cell fate.
Academic Article	Mixed lineage kinase 3 and CD70 cooperation sensitize trastuzumab-resistant HER2+ breast cancer by ceramide-loaded nanoparticles.
Academic Article	Prolylcarboxypeptidase promotes IGF1R/HER3 signaling and is a potential target to improve endocrine therapy response in estrogen receptor positive breast cancer.
Academic Article	CSE1L is a negative regulator of the RB-DREAM pathway in p53 wild-type NSCLC and can be targeted using an HDAC1/2 inhibitor.
Concept	Tumor Protein p73
Academic Article	Determinants of Aurora kinase B inhibitor sensitivity in small cell lung cancer.

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Neoplasms