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Search Results to Thomas DeCoursey

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overview My ORCID is 0000-0002-4263-180X. My Scopus ID is 7005381745. My NIH COMMONS name is TDECOURSEY. Research Areas: The properties and biological functions of ion channels are long-term interests of Tom DeCoursey’s laboratory. A major focus in recent years is the voltage-gated proton channel (Hv1). Modulation of the voltage-dependence of this channel by pHo and pHi ensures that it opens only when the electrochemical gradient for H+ is outward (in most species). In other words, when the proton channel opens, it extrudes acid from cells. In a long collaboration with Dr. Vladimir V. Cherny and others, the behavior of proton channels has been explored in alveolar epithelial cells and in white blood cells (human neutrophils and eosinophils). Immune cells engulf (phagocytose) bacteria and kill parasites by secreting reactive oxygen species (e.g., Chlorox). The enzyme responsible for these heroic actions is NADPH oxidase. This enzyme moves electrons across the cell membrane to form superoxide anion near the invading critters. We measure the electron movement directly as an electrical current. For each electron that leaves, one proton stays in the cell. To prevent massive depolarization as well as acidification, protons exit the cell through proton channels. Without H+ efflux, the killing process would be interrupted prematurely. Fortunately, proton channels are activated, relieving the cell of excess acid, and preventing depolarization. The discovery of proton channels has been a great boon to cells, who until this time had to use other, less efficient means of extruding acid. Identification of proton channel genes in 2006 has transformed the field. More functions are described each year, and structure-function studies are appearing. The channel was shown to be a dimer, with conduction pathway in each protomer. The dimer gates cooperatively - both protomers need to move before either conducts. New genes (over a dozen at last count) are appearing at a high rate. The proton channel resists efforts to crystallize it. The first crystal structure was reported in 2014 by Takeshita et al, is likely closed, and is of a chimera with a Voltage-Sensing Phosphatase. Hv1 triggers the flash in bioluminescent dinoflagellates (Smith et al, 2011), which were recently active in Tasmania! My Faculty Profile at Rush University Medical Center: https://www.rushu.rush.edu/faculty/thomas-decoursey-phd My Laboratory: https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-tom-decoursey-phd http://www.phys.rush.edu/TomD/physiotd.html My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/pubmed/?term=DeCoursey+TE My Scopus: https://www.scopus.com/authid/detail.uri?authorId=7005381745 My ORCID: http://orcid.org/0000-0002-4263-180X Education: PhD, University of Cincinnati College of Medicine BA, McPherson College, Kansas

One or more keywords matched the following items that are connected to DeCoursey, Thomas

Item TypeName
Academic Article Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils.
Academic Article The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps.
Academic Article Interactions between NADPH oxidase-related proton and electron currents in human eosinophils.
Academic Article Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid.
Academic Article Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components.
Academic Article The gp91phox component of NADPH oxidase is not a voltage-gated proton channel.
Academic Article The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels.
Academic Article Temperature dependence of NADPH oxidase in human eosinophils.
Academic Article Interactions between NADPH oxidase and voltage-gated proton channels: why electron transport depends on proton transport.
Academic Article Regulation and termination of NADPH oxidase activity.
Academic Article The pH dependence of NADPH oxidase in human eosinophils.
Academic Article Charge compensation during the phagocyte respiratory burst.
Academic Article Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2 alpha activity.
Academic Article Electrophysiology of the phagocyte respiratory burst. Focus on "Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity".
Academic Article Pharmacology of voltage-gated proton channels.
Academic Article The intimate and mysterious relationship between proton channels and NADPH oxidase.
Academic Article Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis.
Academic Article Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes.
Academic Article Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes.
Academic Article Strong glucose dependence of electron current in human monocytes.
Academic Article NOX5 in human spermatozoa: expression, function, and regulation.
Academic Article Voltage-gated proton channels.
Academic Article Analysis of electrophysiological properties and responses of neutrophils.
Academic Article The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase.
Academic Article Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells.

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