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Duan, Lei
One or more keywords matched the following properties of Duan, Lei
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overview My Scopus number is 55729339900. My NIH COMMONS name is LDUAN1. Research Areas: Basic and translational cancer research with a focus on understanding molecular mechanisms underlying cancer therapy resistance. My Faculty Profile at Rush University Medical Center: https://www.rushu.rush.edu/faculty/lei-duan-md My Laboratory: https://www.rushu.rush.edu/research/departmental-research/cell-molecular-medicine-research/laboratory-lei-duan-md My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48065659/?sort=date&direction=descending My Scopus: https://www.scopus.com/authid/detail.uri?authorId=55729339900 Education: MD, Shanghai Jiaotong University Medical School, China
One or more keywords matched the following items that are connected to Duan, Lei
Item TypeName
Concept Tumor Burden
Concept Brain Neoplasms
Concept Lung Neoplasms
Concept Tumor Suppressor Protein p53
Concept Biomarkers, Tumor
Concept Colorectal Neoplasms
Concept Neoplasm Proteins
Concept Drug Resistance, Neoplasm
Concept Breast Neoplasms
Concept Bone Neoplasms
Concept Tumor Cells, Cultured
Concept Triple Negative Breast Neoplasms
Concept Neoplasms
Concept Cell Line, Tumor
Concept Neoplasm Recurrence, Local
Academic Article Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior.
Academic Article Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.
Academic Article Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells.
Academic Article Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells.
Academic Article Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.
Academic Article Continuous requirement of ErbB2 kinase activity for loss of cell polarity and lumen formation in a novel ErbB2/Neu-driven murine cell line model of metastatic breast cancer.
Academic Article 1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptor a.
Academic Article The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT.
Academic Article Critical roles for nitric oxide and ERK in the completion of prosurvival autophagy in 4OHTAM-treated estrogen receptor-positive breast cancer cells.
Academic Article Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.
Academic Article p53-regulated autophagy is controlled by glycolysis and determines cell fate.
Academic Article Modeling the Etiology of p53-mutated Cancer Cells.
Academic Article Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.
Academic Article The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis.
Academic Article The IGF-1R/AKT pathway determines cell fate in response to p53.
Academic Article p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a.
Academic Article DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a.
Academic Article Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a.
Academic Article JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.
Academic Article The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells.
Academic Article Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer.
Academic Article Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis.
Academic Article Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells.
Academic Article P53-regulated autophagy and its impact on drug resistance and cell fate.
Academic Article Corrigendum to 'Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells'.
Academic Article Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy.
Academic Article RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC.
Academic Article Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15.
Academic Article Prolyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer.
Academic Article Erratum: P53-regulated autophagy and its impact on drug resistance and cell fate.
Academic Article Mixed lineage kinase 3 and CD70 cooperation sensitize trastuzumab-resistant HER2+ breast cancer by ceramide-loaded nanoparticles.
Academic Article Prolylcarboxypeptidase promotes IGF1R/HER3 signaling and is a potential target to improve endocrine therapy response in estrogen receptor positive breast cancer.
Academic Article CSE1L is a negative regulator of the RB-DREAM pathway in p53 wild-type NSCLC and can be targeted using an HDAC1/2 inhibitor.
Academic Article Determinants of Aurora kinase B inhibitor sensitivity in small cell lung cancer.
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  • Neoplasms