A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.

Descriptor ID	D039942
MeSH Number(s)	D12.776.543.750.590.500
Concept/Terms	Neuropilin-1 Neuropilin-1 Neuropilin 1 Sema III Receptor Receptor, Sema III NRP1 Protein Semaphorin III Receptor A5 Antigen Antigen, A5 Npn-1 Protein Npn 1 Protein

Below are MeSH descriptors whose meaning is more general than "Neuropilin-1".

Below are MeSH descriptors whose meaning is related to "Neuropilin-1".

Below are MeSH descriptors whose meaning is more specific than "Neuropilin-1".