"Cardiac Glycosides" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
| Descriptor ID |
D002301
|
| MeSH Number(s) |
D04.210.500.155.580 D09.408.180
|
| Concept/Terms |
Cardiac Glycosides- Cardiac Glycosides
- Glycosides, Cardiac
- Cardiotonic Steroids
- Steroids, Cardiotonic
|
Below are MeSH descriptors whose meaning is more general than "Cardiac Glycosides".
Below are MeSH descriptors whose meaning is more specific than "Cardiac Glycosides".
This graph shows the total number of publications written about "Cardiac Glycosides" by people in this website by year, and whether "Cardiac Glycosides" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cardiac Glycosides" by people in Profiles.
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Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis. Glia. 2022 10; 70(10):1950-1970.
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Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication. J Virol. 2016 Dec 01; 90(23):10715-10727.
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The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function. J Physiol. 2006 Sep 15; 575(Pt 3):845-54.