A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.

Descriptor ID	D039842
MeSH Number(s)	D12.776.395.550.200.250.520.578 D12.776.543.550.200.250.520.578 D23.050.301.350.250.520.578
Concept/Terms	Neural Cell Adhesion Molecule L1 Neural Cell Adhesion Molecule L1 NILE Glycoprotein Glycoprotein, NILE Nerve Growth Factor-Inducible Large External Glycoprotein Nerve Growth Factor Inducible Large External Glycoprotein CALL Protein CamL1 Gene Product Neural Adhesion Molecule L1 L1 Cell Adhesion Molecule L1CAM NILE Protein Cell Adhesion Molecule L1 Cell Surface Glycoprotein L1 NGF-Inducible Glycoprotein Glycoprotein, NGF-Inducible NGF Inducible Glycoprotein F11 Glycoprotein

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