"Caspase 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 7; CASPASE 8; and CASPASE 10. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
| Descriptor ID |
D053178
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| MeSH Number(s) |
D08.811.277.656.262.500.126.350.600 D08.811.277.656.300.200.126.350.600 D12.644.360.075.405.350.600 D12.776.476.075.405.350.600
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caspase 6".
Below are MeSH descriptors whose meaning is more specific than "Caspase 6".
This graph shows the total number of publications written about "Caspase 6" by people in this website by year, and whether "Caspase 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspase 6" by people in Profiles.
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Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment. Acta Neuropathol Commun. 2016 12 08; 4(1):127.
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Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. Cell Death Differ. 2014 May; 21(5):696-706.
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Cerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer disease. J Neuropathol Exp Neurol. 2013 Sep; 72(9):824-32.
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Caspase-6 activity predicts lower episodic memory ability in aged individuals. Neurobiol Aging. 2013 Jul; 34(7):1815-24.
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Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation. J Neurosci. 2010 Apr 28; 30(17):6132-42.
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Activation of caspase-6 in aging and mild cognitive impairment. Am J Pathol. 2007 Apr; 170(4):1200-9.
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Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. J Neurosci. 2004 Sep 08; 24(36):7895-902.