Tissue Inhibitor of Metalloproteinases
"Tissue Inhibitor of Metalloproteinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.
| Descriptor ID |
D019714
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| MeSH Number(s) |
D12.776.645.875
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Tissue Inhibitor of Metalloproteinases".
Below are MeSH descriptors whose meaning is more specific than "Tissue Inhibitor of Metalloproteinases".
This graph shows the total number of publications written about "Tissue Inhibitor of Metalloproteinases" by people in this website by year, and whether "Tissue Inhibitor of Metalloproteinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tissue Inhibitor of Metalloproteinases" by people in Profiles.
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Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc. J Cell Physiol. 2012 Apr; 227(4):1512-20.
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Cycle-dependent matrix remodeling gene expression response in fatigue-loaded rat patellar tendons. J Orthop Res. 2010 Oct; 28(10):1380-6.
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Differential calcium independent regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by interleukin-1beta and transforming growth factor-beta in Peyronie's plaque fibroblasts. J Urol. 2008 Jun; 179(6):2447-55.
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Profiles of matrix metalloproteinases and their tissue inhibitors in intraperitoneal drainage fluid: relationship to wound healing. Wound Repair Regen. 2003 Jul-Aug; 11(4):268-74.
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The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation. Osteoarthritis Cartilage. 2001 Aug; 9(6):539-52.
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Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors. Arch Biochem Biophys. 1997 Aug 15; 344(2):404-12.
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Activation and inhibition of endogenous matrix metalloproteinases in articular cartilage: effects on composition and biophysical properties. Arch Biochem Biophys. 1996 Sep 15; 333(2):359-67.