Multiple Endocrine Neoplasia Type 2a
"Multiple Endocrine Neoplasia Type 2a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
| Descriptor ID |
D018813
|
| MeSH Number(s) |
C04.588.322.400.505 C04.651.600.505 C04.700.630.505 C16.320.700.630.505 C19.344.400.505
|
| Concept/Terms |
Multiple Endocrine Neoplasia Type 2a- Multiple Endocrine Neoplasia Type 2a
- MEA II
- MEA IIa
- MEN 2
- MEN 2a
- MEN II
- MEN IIa
- MEN-2A Syndrome
- MEN 2A Syndrome
- MEN-2A Syndromes
- MEN2a
- Multiple Endocrine Neoplasia Type 2
- Multiple Endocrine Neoplasms Type 2a
- Neoplasia, Multiple Endocrine Type 2a
- Neoplasms, Multiple Endocrine Type 2a
- Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
- Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
- Sipple Syndrome
- Multiple Endocrine Neoplasia, Type IIa
- MEA 2a
|
Below are MeSH descriptors whose meaning is more general than "Multiple Endocrine Neoplasia Type 2a".
Below are MeSH descriptors whose meaning is more specific than "Multiple Endocrine Neoplasia Type 2a".
This graph shows the total number of publications written about "Multiple Endocrine Neoplasia Type 2a" by people in this website by year, and whether "Multiple Endocrine Neoplasia Type 2a" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Multiple Endocrine Neoplasia Type 2a" by people in Profiles.
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Bilateral pheochromocytomas and congenital anomalies associated with a de novo germline mutation in the von Hippel-Lindau gene. Am J Kidney Dis. 2003 Jan; 41(1):E3.