David Williams to NADH, NADPH Oxidoreductases
This is a "connection" page, showing publications David Williams has written about NADH, NADPH Oxidoreductases.
Connection Strength
3.698
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Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis. ACS Infect Dis. 2020 03 13; 6(3):393-405.
Score: 0.734
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Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites. Antioxid Redox Signal. 2013 Sep 01; 19(7):735-45.
Score: 0.442
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Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. Biochim Biophys Acta. 2011 Dec; 1810(12):1262-71.
Score: 0.406
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Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni. Biochemistry. 2011 Jul 05; 50(26):5870-82.
Score: 0.404
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Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med. 2007 Jun; 4(6):e206.
Score: 0.305
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The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase. Mol Biochem Parasitol. 2002 Apr 30; 121(1):129-39.
Score: 0.215
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Ectopic suicide inhibition of thioredoxin glutathione reductase. Free Radic Biol Med. 2020 02 01; 147:200-211.
Score: 0.182
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Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS Chem Biol. 2018 08 17; 13(8):2190-2202.
Score: 0.164
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High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis. Infect Dis Poverty. 2015 Aug 31; 4:40.
Score: 0.135
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Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs. FEBS J. 2015 Aug; 282(16):3199-217.
Score: 0.135
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Proteomic profiling of nitrosative stress: protein S-oxidation accompanies S-nitrosylation. ACS Chem Biol. 2014 Mar 21; 9(3):821-30.
Score: 0.121
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On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases. J Inorg Biochem. 2012 Mar; 108:105-11.
Score: 0.104
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Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J Biol Chem. 2009 Oct 16; 284(42):28977-85.
Score: 0.089
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Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med. 2008 Apr; 14(4):407-12.
Score: 0.081
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Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. Nat Commun. 2023 06 22; 14(1):3737.
Score: 0.058
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Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. ACS Infect Dis. 2021 07 09; 7(7):1932-1944.
Score: 0.050
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New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni. Eur J Med Chem. 2014 Sep 12; 84:135-45.
Score: 0.031
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Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J Med Chem. 2009 Oct 22; 52(20):6474-83.
Score: 0.023
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Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Negl Trop Dis. 2008 Jan 02; 2(1):e127.
Score: 0.020