David Williams to Enzyme Inhibitors
This is a "connection" page, showing publications David Williams has written about Enzyme Inhibitors.
Connection Strength
2.613
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Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis. ACS Infect Dis. 2020 03 13; 6(3):393-405.
Score: 0.605
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Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni. Antimicrob Agents Chemother. 2013 Dec; 57(12):5969-76.
Score: 0.390
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Gold-containing compounds target an apicomplexan Thioredoxin reductase: Disclosing reactivity through structural and functional characterization. Int J Biol Macromol. 2026 Jun; 369:152627.
Score: 0.234
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Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy. Redox Biol. 2026 03; 90:103980.
Score: 0.228
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Pleiotropic anti-cancer activities of novel non-covalent thioredoxin reductase inhibitors against triple negative breast cancer. Free Radic Biol Med. 2025 02 01; 227:201-209.
Score: 0.212
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The "Doorstop Pocket" In Thioredoxin Reductases-An Unexpected Druggable Regulator of the Catalytic Machinery. J Med Chem. 2024 Sep 26; 67(18):15947-15967.
Score: 0.209
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Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS Chem Biol. 2018 08 17; 13(8):2190-2202.
Score: 0.135
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High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis. Infect Dis Poverty. 2015 Aug 31; 4:40.
Score: 0.112
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Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs. FEBS J. 2015 Aug; 282(16):3199-217.
Score: 0.111
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New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni. Eur J Med Chem. 2014 Sep 12; 84:135-45.
Score: 0.103
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Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J Med Chem. 2009 Oct 22; 52(20):6474-83.
Score: 0.074
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A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase. Assay Drug Dev Technol. 2008 Aug; 6(4):551-5.
Score: 0.068
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Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med. 2008 Apr; 14(4):407-12.
Score: 0.067
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Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Negl Trop Dis. 2008 Jan 02; 2(1):e127.
Score: 0.066