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David Williams to Animals

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This is a "connection" page, showing publications David Williams has written about Animals.
David Williams
Connection Strength
2.002
Animals
  1. Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis. ACS Infect Dis. 2020 03 13; 6(3):393-405.
    View in: PubMed
    Score: 0.094
  2. The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004279.
    View in: PubMed
    Score: 0.071
  3. Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni. Antimicrob Agents Chemother. 2013 Dec; 57(12):5969-76.
    View in: PubMed
    Score: 0.061
  4. Characterization of the phytochelatin synthase from the human parasitic nematode Ancylostoma ceylanicum. Mol Biochem Parasitol. 2013 Sep; 191(1):1-6.
    View in: PubMed
    Score: 0.060
  5. Towards an understanding of the function of the phytochelatin synthase of Schistosoma mansoni. PLoS Negl Trop Dis. 2013; 7(1):e2037.
    View in: PubMed
    Score: 0.058
  6. Transcriptional analysis of a unique set of genes involved in Schistosoma mansoni female reproductive biology. PLoS Negl Trop Dis. 2012; 6(11):e1907.
    View in: PubMed
    Score: 0.057
  7. Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites. Antioxid Redox Signal. 2013 Sep 01; 19(7):735-45.
    View in: PubMed
    Score: 0.057
  8. The redox biology of schistosome parasites and applications for drug development. Curr Pharm Des. 2012; 18(24):3595-611.
    View in: PubMed
    Score: 0.054
  9. Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. Biochim Biophys Acta. 2011 Dec; 1810(12):1262-71.
    View in: PubMed
    Score: 0.052
  10. Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni. Biochemistry. 2011 Jul 05; 50(26):5870-82.
    View in: PubMed
    Score: 0.052
  11. Characterization of the phytochelatin synthase of Schistosoma mansoni. PLoS Negl Trop Dis. 2011 May; 5(5):e1168.
    View in: PubMed
    Score: 0.052
  12. Whole mount in situ hybridization methodology for Schistosoma mansoni. Mol Biochem Parasitol. 2011 Jul-Aug; 178(1-2):46-50.
    View in: PubMed
    Score: 0.051
  13. Characterization of the methionine sulfoxide reductases of Schistosoma mansoni. J Parasitol. 2009 Dec; 95(6):1421-8.
    View in: PubMed
    Score: 0.047
  14. Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med. 2008 Apr; 14(4):407-12.
    View in: PubMed
    Score: 0.041
  15. Proteomic analysis of Schistosoma mansoni egg secretions. Mol Biochem Parasitol. 2007 Oct; 155(2):84-93.
    View in: PubMed
    Score: 0.039
  16. Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med. 2007 Jun; 4(6):e206.
    View in: PubMed
    Score: 0.039
  17. Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE). Exp Parasitol. 2007 Nov; 117(3):246-58.
    View in: PubMed
    Score: 0.039
  18. Schistosoma mansoni albumin, a major defense against oxidative damage, was acquired by lateral gene transfer from a mammalian host. Mol Biochem Parasitol. 2006 Dec; 150(2):359-63.
    View in: PubMed
    Score: 0.037
  19. Endothelial c-IAP2 loss amplifies P2X7 receptor-driven inflammation and worsens schistosomiasis-associated pulmonary hypertension. Proc Natl Acad Sci U S A. 2026 06 23; 123(25):e2513158123.
    View in: PubMed
    Score: 0.037
  20. Synthesis of Methoxylated Benzoxanthones as Drug Metabolites of Antischistosomal Schistodiones-A Limited Environmental Risk. Molecules. 2026 May 27; 31(11).
    View in: PubMed
    Score: 0.037
  21. Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets. J Biol Chem. 2006 Jun 23; 281(25):17001-17010.
    View in: PubMed
    Score: 0.036
  22. Examination of Coligands in Mefloquine-Metal Complexes Reveals the Structural Determinants of Activity against Plasmodium falciparum and Schistosoma mansoni. J Med Chem. 2026 Apr 23; 69(8):9242-9264.
    View in: PubMed
    Score: 0.036
  23. Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy. Redox Biol. 2026 03; 90:103980.
    View in: PubMed
    Score: 0.035
  24. Murine immune responses to a novel schistosome egg antigen, SmEP25. Int J Parasitol. 2005 Jul; 35(8):875-82.
    View in: PubMed
    Score: 0.034
  25. Pleiotropic anti-cancer activities of novel non-covalent thioredoxin reductase inhibitors against triple negative breast cancer. Free Radic Biol Med. 2025 02 01; 227:201-209.
    View in: PubMed
    Score: 0.033
  26. Regioselective Synthesis of Potential Non-Quinonoid Prodrugs of Plasmodione: Antiparasitic Properties Against Two Hemoglobin-Feeding Parasites and Drug Metabolism Studies. Molecules. 2024 Nov 07; 29(22).
    View in: PubMed
    Score: 0.033
  27. The "Doorstop Pocket" In Thioredoxin Reductases-An Unexpected Druggable Regulator of the Catalytic Machinery. J Med Chem. 2024 Sep 26; 67(18):15947-15967.
    View in: PubMed
    Score: 0.032
  28. Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni. J Biol Chem. 2004 Jun 18; 279(25):26159-66.
    View in: PubMed
    Score: 0.032
  29. Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut-lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression. Front Immunol. 2023; 14:1254762.
    View in: PubMed
    Score: 0.030
  30. Characterisation of a Rho homologue of Schistosoma mansoni. Int J Parasitol. 2003 Jul; 33(7):721-31.
    View in: PubMed
    Score: 0.030
  31. Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. Nat Commun. 2023 06 22; 14(1):3737.
    View in: PubMed
    Score: 0.030
  32. Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from Schistosoma mansoni. Biochemistry. 2023 05 02; 62(9):1497-1508.
    View in: PubMed
    Score: 0.029
  33. Adenylosuccinate lyase of Schistosoma mansoni: gene structure, mRNA expression, and analysis of the predicted peptide structure of a potential chemotherapeutic target. Int J Parasitol. 2002 Nov; 32(12):1487-95.
    View in: PubMed
    Score: 0.029
  34. Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin. Int J Parasitol. 2002 Sep; 32(10):1285-92.
    View in: PubMed
    Score: 0.028
  35. The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase. Mol Biochem Parasitol. 2002 Apr 30; 121(1):129-39.
    View in: PubMed
    Score: 0.028
  36. Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus. Redox Biol. 2022 05; 51:102278.
    View in: PubMed
    Score: 0.027
  37. Traditional Kenyan herbal medicine: exploring natural products' therapeutics against schistosomiasis. J Helminthol. 2022 Mar 03; 96:e16.
    View in: PubMed
    Score: 0.027
  38. Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. ACS Infect Dis. 2021 07 09; 7(7):1932-1944.
    View in: PubMed
    Score: 0.026
  39. Schistosome infection stimulates host CD4(+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase. Infect Immun. 2001 Feb; 69(2):1134-41.
    View in: PubMed
    Score: 0.025
  40. Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections. Molecules. 2020 Nov 01; 25(21).
    View in: PubMed
    Score: 0.025
  41. Molecular and enzymatic characterization of Schistosoma mansoni thioredoxin peroxidase. J Parasitol. 2000 Oct; 86(5):908-15.
    View in: PubMed
    Score: 0.025
  42. Ectopic suicide inhibition of thioredoxin glutathione reductase. Free Radic Biol Med. 2020 02 01; 147:200-211.
    View in: PubMed
    Score: 0.023
  43. Development and optimization of a high-throughput screening method utilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics. PLoS One. 2019; 14(6):e0217019.
    View in: PubMed
    Score: 0.023
  44. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS Chem Biol. 2018 08 17; 13(8):2190-2202.
    View in: PubMed
    Score: 0.021
  45. High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis. Infect Dis Poverty. 2015 Aug 31; 4:40.
    View in: PubMed
    Score: 0.017
  46. Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs. FEBS J. 2015 Aug; 282(16):3199-217.
    View in: PubMed
    Score: 0.017
  47. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534.
    View in: PubMed
    Score: 0.017
  48. New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni. Eur J Med Chem. 2014 Sep 12; 84:135-45.
    View in: PubMed
    Score: 0.016
  49. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem Biol. 2013 Aug 22; 20(8):991-1001.
    View in: PubMed
    Score: 0.015
  50. Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents. Org Biomol Chem. 2012 Aug 21; 10(31):6375-6387.
    View in: PubMed
    Score: 0.014
  51. Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni. PLoS Negl Trop Dis. 2012; 6(6):e1686.
    View in: PubMed
    Score: 0.014
  52. Molecular cloning and sequencing of glutathione peroxidase from Schistosoma mansoni. Mol Biochem Parasitol. 1992 May; 52(1):127-30.
    View in: PubMed
    Score: 0.014
  53. Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin. Structure. 2012 Mar 07; 20(3):429-39.
    View in: PubMed
    Score: 0.014
  54. On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases. J Inorg Biochem. 2012 Mar; 108:105-11.
    View in: PubMed
    Score: 0.013
  55. An atlas for Schistosoma mansoni organs and life-cycle stages using cell type-specific markers and confocal microscopy. PLoS Negl Trop Dis. 2011 Mar 08; 5(3):e1009.
    View in: PubMed
    Score: 0.013
  56. Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J Med Chem. 2009 Oct 22; 52(20):6474-83.
    View in: PubMed
    Score: 0.012
  57. Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J Biol Chem. 2009 Oct 16; 284(42):28977-85.
    View in: PubMed
    Score: 0.011
  58. The genome of the blood fluke Schistosoma mansoni. Nature. 2009 Jul 16; 460(7253):352-8.
    View in: PubMed
    Score: 0.011
  59. Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation. Mol Biochem Parasitol. 2009 Sep; 167(1):20-31.
    View in: PubMed
    Score: 0.011
  60. Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. FASEB J. 2008 Nov; 22(11):4022-32.
    View in: PubMed
    Score: 0.011
  61. A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase. Assay Drug Dev Technol. 2008 Aug; 6(4):551-5.
    View in: PubMed
    Score: 0.011
  62. Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Negl Trop Dis. 2008 Jan 02; 2(1):e127.
    View in: PubMed
    Score: 0.010
  63. Boudicca, a retrovirus-like long terminal repeat retrotransposon from the genome of the human blood fluke Schistosoma mansoni. J Virol. 2003 Jun; 77(11):6153-66.
    View in: PubMed
    Score: 0.007
  64. Differential production in vitro of antigen specific IgG1, IgG3 and IgA: a study in Schistosoma haematobium infected individuals. Parasite Immunol. 2003 Jan; 25(1):39-44.
    View in: PubMed
    Score: 0.007
  65. Construction and characterization of a Schistosoma mansoni bacterial artificial chromosome library. Genomics. 2000 Apr 15; 65(2):87-94.
    View in: PubMed
    Score: 0.006
  66. Schistosoma mansoni: characterization of sequence variants of the 28-kDa glutathione S-transferase. Exp Parasitol. 1994 Aug; 79(1):81-4.
    View in: PubMed
    Score: 0.004
  67. Cloning and characterization of the gene encoding Schistosoma mansoni glutathione peroxidase. Gene. 1994 Jan 28; 138(1-2):149-52.
    View in: PubMed
    Score: 0.004
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